DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and SLC12A5

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001128243.1	Gene:	SLC12A5 / 57468	HGNCID:	13818	Length:	1139	Species:	Homo sapiens

Alignment Length:	1119	Identity:	575/1119 - (51%)
Similarity:	779/1119 - (69%)	Gaps:	82/1119 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAAT 81
            |.|.:..::.|..|..          |.....|:.|::::::|.|.:|:.:|.:|||.| :|..:
Human    45 PKESSPFINSTDTEKG----------KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTN-LPQGS 98

  Fly    82 ---------DPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCC 137
                     :...|....:.||||.:||:|||:|||||||||:|||||||.||.:..|.:|..||
Human    99 REHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICC 163

  Fly   138 CVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLT 202
            ..|||||||||||||||||||||||:|||||||||||||||:.||.|||.|.||||:|.:||:|.
Human   164 SCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLA 228

  Fly   203 YMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAV 265
            |:.|..:||  .|.:.:|.||.||.|||||.:|..|..:||:|||:|||||.|.|.||||||:|:
Human   229 YLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAI 293

  Fly   266 YVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTK--------EDSFLRDIYCP----DGKCEEYY 318
            |.|:..:........:|:||.|.|.....:.|.|        ..:.|..::|.    :..|:||:
Human   294 YAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYF 358

  Fly   319 LANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFIS-YGKSAIDIENTS--GESYNQIMADITTSF 380
            ..||||:::||.|.|||:..:|::.|:|.||..:. .|.:::.:.:.:  ...:..:.:|:|:.|
Human   359 TRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYF 423

  Fly   381 TLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDK 445
            |||:||:|||||||||||||||||.|||||||.|||.||.|||.||:|||:.|...::.::||||
Human   424 TLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDK 488

  Fly   446 FGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSK 510
            ||:::.|.|||..:|||:.|||:||||.||.|||||||||||||||||:||.|:|||..|.....
Human   489 FGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA 553

  Fly   511 RGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYH 575
            .||||.|||||..||:.|||:.::|.:||:|||||||||.|||||||||||||||||||||::||
Human   554 NGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYH 618

  Fly   576 WSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRL 640
            |:||.:|::||:::|.:.|||:||:||.:|.:||||||||||||||||||||::|:||||:||||
Human   619 WTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRL 683

  Fly   641 EEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDA 705
            |||||||||||||:|||.:::.:....:.::.|..:||||||||||..||::|...:...:|..|
Human   684 EEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRA 748

  Fly   706 KATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-EGRNSWKT 769
            :.::|:.|..|||||||.|:::..:.:|:|.:||:.||||::.|||::|||.:||| |...:|:.
Human   749 EESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRN 813

  Fly   770 FIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCK 833
            ||:.||...|.|:||:|.|.::.:|.:..:.. |:||:||||||||:||||||||:.|:.||.||
Human   814 FIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 878

  Fly   834 LRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALG 898
            :|||||||::||||||||||.||||||||.|:||||||:.|||||||||:||:||||:|:|:.:.
Human   879 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMH 943

  Fly   899 LNKKENSKVVQTIMD------YKETPSDNKMSL-----------------VQTIVDHHYDATKTA 940
            |.|.|..:.:|:|.|      .::.|::.::.|                 ||.|.|      ::|
Human   944 LTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHD------QSA 1002

  Fly   941 SKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADG--DFKSSVKPD- 1002
            .....:.|:..|....:.:.|.::  :.|...::....|  .||..|...::|  || .|:||:
Human  1003 PSCPSSSPSPGEEPEGEGETDPEK--VHLTWTKDKSVAE--KNKGPSPVSSEGIKDF-FSMKPEW 1062

  Fly  1003 ----EFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVL 1063
                :.||||||||::||||||:||:||:||::|:|||||  ....:.|||||||||||.|::|:
Human  1063 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPR--NRNGDENYMEFLEVLTEHLDRVM 1125

  Fly  1064 MVRGGGREVITIYS 1077
            :|||||||||||||
Human  1126 LVRGGGREVITIYS 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	568/1085 (52%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	205/434 (47%)
SLC12A5	NP_001128243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		5/27 (19%)
		2a30	44..1139	CDD:273347	573/1117 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..116		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..1052		21/119 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158239
Domainoid	1	1.000	426	1.000	Domainoid score	I605
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1162	1.000	Inparanoid score	I205
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm41076
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770