Protein Alignment kcc and SLC12A9

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_001350422.1
• Gene: SLC12A9 / 56996
• HGNCID: 17435
• Length: 914
• Species: Homo sapiens
• Alignment Length: 1067
• Identity: 269/1067 - (25%)
• Similarity: 428/1067 - (40%)
• Gaps: 276/1067 - (25%)

  Fly    87 PAAPSAR-MGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAI 150
            |...||| :.|.:||.:|.:.::|.:::|:|:.:|||.||.:....::|....:..||.:|:.||
Human    29 PGGASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAI 93

  Fly   151 ATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFT 215
            ||||.|..||:||||||:||||.||::|::||.......|:.::|.||.||       .:||
Human    94 ATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVL-------DVFG--- 148

  Fly   216 KDADAM-----------YNNFRVYGTLLLIFMGLIVFLGVKFVNK--FATV-----ALACVILSI 262
              |||.           |....:||:|||..:|.:..||.....:  |.|.     :||.|::|.
Human   149 --ADATGPSGLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISF 211

  Fly   263 IAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVK 327
            :||                   |.|.::..|...             |:|
Human   212 VAV-------------------GPRDIRLTPRPG-------------PNG--------------- 229

  Fly   328 GIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADITT----SFTLLIGIFF 388
                       .::.|.|   |.|..:..|.  :::..|..|.:   |.||    :|..:..:.|
Human   230 -----------SSLPPRF---GHFTGFNSST--LKDNLGAGYAE---DYTTGAVMNFASVFAVLF 275

  Fly   389 PSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAG--TVDNLLLRDKFGQSIG 451
            ...||||||:|.||:|.|..::||:|||.|:..|..||:  ::||..  |.|..||::.:|
Human   276 NGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV--LLFFLSSFTCDRTLLQEDYG---- 334

  Fly   452 GKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEII-PFLAPFAKSSKRGEPT 515
              ...|...||.  ::|||.:.:.|.|.:.||.||.|:|.|:|||::. ..|||....|:.|.|.
Human   335 --FFRAISLWPP--LVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPW 395

  Fly   516 RALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSL 580
            .|:|.:..:.|..:|.|.::.||.::::|:|:.|..|:|:|........||:||.|..:.|...|
Human   396 AAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCL 460

  Fly   581 IGLTLCISVMIMTSWYFA---LIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEE 642
            :|:..|:.:|.:.|...|   |:.||:...:   :..||....||...:.:.....|..||||:.
Human   461 LGVASCLLMMFLISPGAAGGSLLLMGLLAAL---LTARGGPSSWGYVSQALLFHQVRKYLLRLDV 522

  Fly   643 GPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKA 707
            ...|.|.||||:|:|.......||..|    .|.|||.| ||.:...|..||...:.:..|..:.
Human   523 RKDHVKFWRPQLLLLVGNPRGALPLLR----LANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQY 582

  Fly   708 TLRKYMTDE-KVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGW---------------- 755
            .....:.|. :||.|.|:.::..:.:|...:::..|||||||||:::|:
Human   583 GAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAF 647

  Fly   756 --PYSWRQEGRN-------------------SWKTFIQTVRTVAACHMALMVPKGINFYPESNHK 799
              |....:||.:                   :.:.::.||......:..:::.:.....|.....
Human   648 SEPADSTREGSSPALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLS 712

  Fly   800 IGG-------NIDIW------------WIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDN 845
            .|.       ::|:|            ::...|..|:.:..:|.....|.:.:||||......:.
Human   713 RGSGGTSQLHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREA 777

  Fly   846 SIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQT 910
            ....:..|:..|..|||.|:|:.|...                      ...|..:.|
Human   778 PGAAEGRLRALLSQLRIRAEVQEVVWG----------------------EGAGAGEPE------- 813

  Fly   911 IMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENA 975
                .|...|        .|:......:..:..|.|:..:...|...:....       .|||..
Human   814 ----AEEEGD--------FVNSGRGDAEAEALARSANALVRAQQGRGTGGGP-------GGPEGG 859

  Fly   976 DTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREV 1040
            |              |:|...:                              |..:.||.||.:
Human   860 D--------------AEGPITA------------------------------LTFLYLPRPPAD- 879

  Fly  1041 RAERERNYMEFLEVLTEGLEKVLMVRG 1067
             ..|...|:..||.||..|...|:|.|
Human   880 -PARYPRYLALLETLTRDLGPTLLVHG 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	269/1067 (25%)
		SLC12	674..1077	CDD:281515	81/451 (18%)
SLC12A9	NP_001350422.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	844..863		6/39 (15%)
		SLC12	36..905	CDD:332077	264/1058 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..678		3/35 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910