DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and slc12a7b

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	XP_005162967.1	Gene:	slc12a7b / 567667	ZFINID:	ZDB-GENE-030829-61	Length:	1138	Species:	Danio rerio

Alignment Length:	1112	Identity:	570/1112 - (51%)
Similarity:	769/1112 - (69%)	Gaps:	83/1112 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAA- 80
            |.|.:..::.| ::|.|:::..:         |:.|:::::::.|.:|:.::.:|||.|.....
Zfish    59 PRESSPFINNT-DDDKGNLYDGK---------NMALFEEEMDSNPMVSSLLNKLANYTNLTQGVR 113

  Fly    81 ----TDPD---AKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCC 138
                .|.|   .|....|.:|||.|||:|||:|||.|||||:|:||:|||||.:..|:||..||.
Zfish   114 EHEEADEDEGAKKQTVKSPQMGTFIGVYLPCLQNILGVILFLRMTWIVGTAGILEAFIIVSMCCS 178

  Fly   139 VTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTY 203
            .|||||||||||||||||||||||:|||||||||||||||:.||.|||.|.||||:|.:||:|||
Zfish   179 CTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLTY 243

  Fly   204 MAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVY 266
            :.|.|:||  .|...:|:|:.||.|||||..|..|.|:||:|||:|||.|.|.||||:|||:|:|
Zfish   244 IVPSAAIFKAEDKADEAEALLNNMRVYGTCCLTLMALVVFVGVKYVNKLALVFLACVVLSILAIY 308

  Fly   267 VGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKED--------SFLRDIYCP----DGKCEEYYL 319
            .|:...|.......:||||.|.|::...:.|.|.:        :.|..::|.    :..|.||:.
Zfish   309 AGVIKTIFEPPVFPVCVLGNRTLQNHDFDKCMKTEIIDNVTVTTKLWSLFCSGPELNASCNEYFT 373

  Fly   320 ANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESY-NQIMADITTSFTLL 383
            .|:||:::||.||.|||..:|::..:...|..:.....::...::|.:.| ..::.|||..||||
Zfish   374 LNSVTEIQGIPGLTSGVISENMWGKYGPAGMLVEKDIPSVSASDSSQDKYMPYVVNDITAFFTLL 438

  Fly   384 IGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQ 448
            :||:|||||||||||||||||.|||:|||||||.||.||:.:|||.|:.|...::.::||||||.
Zfish   439 VGIYFPSVTGIMAGSNRSGDLRDAQRSIPIGTILAIATTTIIYLSCVVLFGACIEGVVLRDKFGD 503

  Fly   449 SIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGE 513
            |:.|.||:..::||:.|||:||||.|..||||||||||||||||||||.|:|||..|......||
Zfish   504 SVKGNLVIGTLSWPSPWVIVIGSFFSCCGAGLQSLTGAPRLLQAIARDGIVPFLEVFGHGKANGE 568

  Fly   514 PTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSL 578
            ||.|||||.:||:.|||:.::|.:||:|||||||||.|||||||:||||||||||||||:|||:|
Zfish   569 PTWALLLTALICESGILIASLDAVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFKYYHWAL 633

  Fly   579 SLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEG 643
            |.:|::||:::|.::|||:||:||.:|..||||||||||||||||||||::|.||||:|:||||.
Zfish   634 SFLGMSLCLALMFISSWYYALVAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALIRLEEA 698

  Fly   644 PPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKAT 708
            ||||||||||:|||..|:..|..|:.::.||.|||||||||||..||::|.:....|:|..|:..
Zfish   699 PPHTKNWRPQMLVLLNLDSELCVKHPRLLSFTTQLKAGKGLTIVGSVLEGTYLSRENQAKRAEQN 763

  Fly   709 LRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEG-RNSWKTFIQ 772
            ::..|..||.||||.|:|:..:.:|:|.::|:.||||||.|:|::.||.:|||.. .::|::||:
Zfish   764 IKSAMAAEKTKGFCHVVVSSNLRDGISHLVQSAGLGGMKHNSVLMAWPSNWRQSSDPHTWRSFIE 828

  Fly   773 TVRTVAACHMALMVPKGINFYPESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIF 837
            |||...|.|:||:|.|.::.:|.......|.||:||||||||:||||||||:||:.|:.||:|||
Zfish   829 TVRETTAAHLALLVAKNVDSFPHQERLTEGTIDVWWIVHDGGMLMLLPFLLRQHKVWKKCKMRIF 893

  Fly   838 TVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKK 902
            ||||::||||||||||:.||||||:.|:||||||::|||||:|||:||:||||:|||:.:.|::.
Zfish   894 TVAQMDDNSIQMKKDLQMFLYHLRLNAEVEVVEMHDSDISAFTYEKTLVMEQRSQMLKQMQLSRT 958

  Fly   903 ENSKVVQTIMD------YKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEE--TQHHDSQ 959
            |..:.:|:|.|      .::..|:...|.:|.        ..||.:.:.....|.:  |..|.:.
Zfish   959 EREREIQSITDESRSSIRRKNQSEAHSSSLQN--------QNTAHEQQDEAQLIHDRNTASHTAM 1015

  Fly   960 NDEKRNSIDLDGPENAD-TPET-----TSNK--DESTEKADGDFKSSV------KPD-----EFN 1005
            ||:            || |||.     |..|  .|.:.:.:.:...:|      ||:     :.|
Zfish  1016 NDK------------ADATPERVHMTWTKEKLFSERSRRTEANASMAVRDLFNMKPEWESLNQSN 1068

  Fly  1006 VRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGR 1070
            ||.||||:|||||||.|||.|.||::|:||||:  ....:.|||||:||:.|||.:||:||||||
Zfish  1069 VRCMHTAVKLNEVIVNKSQGAHLVLLNMPGPPK--NRGGDENYMEFMEVMMEGLNRVLLVRGGGR 1131

  Fly  1071 EVITIYS 1077
            |||||||
Zfish  1132 EVITIYS 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	563/1078 (52%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	201/430 (47%)
slc12a7b	XP_005162967.1	2a30	58..1138	CDD:273347	568/1110 (51%)
		SLC5-6-like_sbd	182..>319	CDD:294310	90/136 (66%)
		SLC12	724..978	CDD:281515	133/253 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594147
Domainoid	1	1.000	431	1.000	Domainoid score	I565
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1166	1.000	Inparanoid score	I194
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm25212
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770