DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and slc12a4

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	XP_691291.2	Gene:	slc12a4 / 562826	ZFINID:	ZDB-GENE-090218-27	Length:	1095	Species:	Danio rerio

Alignment Length:	1098	Identity:	612/1098 - (55%)
Similarity:	786/1098 - (71%)	Gaps:	81/1098 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HNGTV----HETKNEDSGDIHRAEENQKSS--IDPNLYLYDDDLETRPHISTFISSIANYENTIP 78
            |..||    |....|||..:..::...|.:  .|.||.|::::|:.||.:|:.:|.:.||.|...
Zfish    39 HGDTVSSDGHGNHKEDSPFLSSSDSASKRNDFYDRNLALFEEELDIRPKVSSLLSRLVNYTNVTQ 103

  Fly    79 AA--------TDPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLT 135
            .|        .|...:.|..|..||||:||:|||:|||||||||:||||:|||||.|..|||||.
Zfish   104 GAKEHEEAESADASRRQAPKSPNMGTLMGVYLPCLQNIFGVILFLRLTWIVGTAGVVQSFLIVLM 168

  Fly   136 CCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIV 200
            ||..|||||||||||||||||||||:|||||||||||||||||:.||.|||.||||||:||:||.
Zfish   169 CCSCTMLTAISMSAIATNGVVPAGGAYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEIF 233

  Fly   201 LTYMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSII 263
            |.|:.|.|:||  .|......||.||.|||||:.|..|.::||:|||:|||.|::.|||||:||:
Zfish   234 LKYLIPQAAIFHPADIHAGNGAMLNNMRVYGTICLSLMAVVVFVGVKYVNKLASLFLACVIISIV 298

  Fly   264 AVYVGIFDNIHGNEKLYMCVLGKRLL---------KDIPLENCTKEDSFLRDIYCPD----GKCE 315
            ::|.|...:|....:..:|:||.|.|         |.:.:.|.|......::....|    ..|:
Zfish   299 SIYAGAVKSIFHPPEFPICMLGNRTLVRDLFDVCGKTVVVGNETVPSKLWKNFCTSDNISSAHCD 363

  Fly   316 EYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGK-SAIDIENTSGESYN-QIMADITT 378
            ||:..||||::|||.|||||:..:|::..::||||.:...| .::|:.. |.|::. .:.|||.|
Zfish   364 EYFFHNNVTEIKGIPGLASGIIKENMWGDYMEKGQILEKAKLPSVDVHG-SMETFGFYVSADIAT 427

  Fly   379 SFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLR 443
            |||||:||||||.|||||||||||||.|||||||||||.||.|||.||.|||:.|...::.::||
Zfish   428 SFTLLVGIFFPSATGIMAGSNRSGDLRDAQKSIPIGTILAITTTSLVYFSSVVLFGACIEGVVLR 492

  Fly   444 DKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS 508
            ||||.::...|||..::||:.|||:||||.||:||||||||||||||||||:|.|||||..|...
Zfish   493 DKFGDAVSKNLVVGTLSWPSPWVIVIGSFFSTVGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHG 557

  Fly   509 SKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKF 573
            ...||||.|||||.:|.:.|||:.::|::||:|||||||||.|||||||||||||||||||||::
Zfish   558 KANGEPTWALLLTGLIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFRY 622

  Fly   574 YHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLL 638
            |||:||.:|:::|:::|.::|||:|::|||:|.:|||||||:||||||||||||::|:|||||||
Zfish   623 YHWALSFLGMSMCLALMFISSWYYAIVAMGIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYSLL 687

  Fly   639 RLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAV 703
            |||.|||||||||||:|||.||:::|..||.::.:||:||||||||||..|||:|:..:...:..
Zfish   688 RLEAGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGNFLECYGETQ 752

  Fly   704 DAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-EGRNSW 767
            .::..::..|..|:|||||.|:||.::.||::.:||:.||||||.|||::||||.||| |...:|
Zfish   753 ASEQAIKNMMEIERVKGFCQVVVASKVREGIAHLIQSCGLGGMKHNTVVMGWPYGWRQSEDPRAW 817

  Fly   768 KTFIQTVRTVAACHMALMVPKGINFYPESNHK--IGGNIDIWWIVHDGGLLMLLPFLLKQHRTWR 830
            ||||.|||...|.|:||||||.::||| |||:  ..|.||:||||||||:|||||||||||:.||
Zfish   818 KTFINTVRCTTAAHLALMVPKNVSFYP-SNHERFTDGYIDVWWIVHDGGMLMLLPFLLKQHKVWR 881

  Fly   831 NCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLR 895
            .||:|||||||::||||||||||.||||.||:||:||||||::|||||||||||||||||:|||:
Zfish   882 KCKMRIFTVAQMDDNSIQMKKDLATFLYQLRLEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLK 946

  Fly   896 ALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQN 960
            .:.|:..|..:..|.:.|        :.||::.                           ....:
Zfish   947 QMRLSSAERDREAQLVKD--------RHSLIRM---------------------------GSLYS 976

  Fly   961 DEKRNSIDLDGPENADTPETTSNKDESTEK----ADGDFKS--SVKPDEFNVRRMHTAIKLNEVI 1019
            ||:..:|::...:|..|  .||.|.|:..:    |..:|:.  |:|||:.||||||||:||||||
Zfish   977 DEEEETIEILPEKNQMT--WTSEKIEAERRNRNNAPENFRELISIKPDQSNVRRMHTAVKLNEVI 1039

  Fly  1020 VEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            |.||.||:||::|:|||||  ..|.:.||||||||||||||:||:|||||||||||||
Zfish  1040 VNKSHDARLVLLNMPGPPR--NQEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	601/1061 (57%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	222/411 (54%)
slc12a4	XP_691291.2	2a30	50..1095	CDD:273347	606/1085 (56%)
slc12a4	XP_691291.2	SLC12	718..1095	CDD:281515	222/416 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594133
Domainoid	1	1.000	431	1.000	Domainoid score	I565
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21056
Inparanoid	1	1.050	1166	1.000	Inparanoid score	I194
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm25212
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3041
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800