Protein Alignment kcc and slc12a10.3

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_021333240.1
• Gene: slc12a10.3 / 562763
• ZFINID: ZDB-GENE-060503-518
• Length: 1001
• Species: Danio rerio
• Alignment Length: 1180
• Identity: 304/1180 - (25%)
• Similarity: 478/1180 - (40%)
• Gaps: 322/1180 - (27%)

  Fly    17 PSEHNGTVHETKNEDSGD--IHRAEENQKSSI------DPNLYLYDDDLET------RPHISTFI 67
            |.|:| ....|.|.:..|  :.:.::.:|.||      .|....|..|..|      ||.:....
Zfish    22 PPENN-LQDVTMNLEKVDYVMEQEQDKRKMSIFNPLDPTPKFEFYAKDTWTGRIKSARPSLDVLR 85

  Fly    68 SSIANYENTIPAATDPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLI 132
            .|  ...:.:|...:.|.:|.....|.|.::||.:.|:.||:|||:|:||.|:...||.:..::|
Zfish    86 KS--PDPDDLPPPPEDDGRPKVKLVRFGWVLGVMIRCMLNIWGVIMFLRLPWITSQAGIILTYVI 148

  Fly   133 VLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAV 197
            :.....:|.:||.|:|||:|||.|.:||:||:||||||||.|..:|:||.....||.::..||..
Zfish   149 IFMSVTITTITATSVSAISTNGKVYSGGTYFLISRSLGPELGAPIGLLFSFANALACSLNTVGFA 213

  Fly   198 EIVLTYMAPWASIFGDFTKDADAM----YNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACV 258
            |.|           .|..|:.:|.    .|:.|:.||:.:..:.||.|.|:.:..|...:....:
Zfish   214 ETV-----------RDVLKENNAQMVDDVNDVRIIGTITVCILLLITFAGMAWEAKAQILFFIAL 267

  Fly   259 ILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNV 323
            ::|:...:||                  .||...|.:...
Zfish   268 LISLANYFVG------------------TLLPPTPEKQAV------------------------- 289

  Fly   324 TKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFF 388
                |..|..:.:|.||:.|||        .||..                    ||..:..|||
Zfish   290 ----GFFGYRAEIFVDNLLPSF--------RGKDG--------------------SFFRMFSIFF 322

  Fly   389 PSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFG------ 447
            ||.|||::|.|..|||.|....||.||:.||..|:..||    ..|.||...::||..|
Zfish   323 PSATGILSGVNICGDLKDPSGGIPKGTLLAIFWTTVSYL----LIAITVAASVVRDASGNLNDSL 383

  Fly   448 --------QSIGGKL---------------------VVANIAWPNQWVILIGSFLSTLGAGLQSL 483
                    ..:|.||                     .:...|.....:|.||.|.:||.:.|..|
Zfish   384 ALDSSIQCSGLGCKLGWNFDHCEQNHTCSFGLANYFQILTTASGTGHLITIGIFAATLSSALGFL 448

  Fly   484 TGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLM 547
            ..||::.|.:.:|.|.|::..|.|. .|..||.|..||...|....||:|:::.:|||:|.|||.
Zfish   449 VSAPKIFQCLCKDNIYPYIGFFGKGYGKNQEPLRGYLLMFFIALAFILIGDLNTIAPLISNFFLC 513

  Fly   548 CYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYI 612
            .||.:|.:|...|:.::|.|||.:.::....||....|...:|.:.:|:.||:...:.:.:..|:
Zfish   514 SYGLINFSCFHATITKSPGWRPHYHYFSPWTSLFAAFLSFILMFLFTWWAALVTFAIVLSLLGYV 578

  Fly   613 EYRGAEKEWGDGIR----GMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFS 673
            .|:..:..||...:    .|||:.: .||..:|:   |.||:|||.|||:. ..|:.|   .:..
Zfish   579 TYKKPKINWGTSYQASFYNMALSFS-MSLTGVED---HVKNFRPQCLVLTG-PPNVRP---ALVD 635

  Fly   674 FATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTD--------EKVKGFCDVLVAQQI 730
            |.........|.||.::.          .|:.|:...::.||        .||:.|.....|..:
Zfish   636 FVGTFTKNISLMICGNIF----------MVEEKSRFPQHSTDMLVDWLNQRKVRAFYTSFTADSL 690

  Fly   731 GEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRT-------VAACHM------ 782
            .||..|::|..|||.:||||:::|:..:|::......:.:..|:..       :|...|
Zfish   691 TEGTHSLMQASGLGKLKPNTLVLGYKTNWQECKPERLQDYFNTISDAFDSSYGIAVLRMMDGLDI 755

  Fly   783 ----------ALMVP--------KGINFYPESNHKI---GGN---------------IDIWWIVH 811
                      |:..|        |..|...:.|..|   |.|               |||:||..
Zfish   756 REDLTSGRSSAIDNPAFEADENTKSENEETDRNSDISDDGSNDQVKTVFQTKQGRKTIDIYWISD 820

  Fly   812 DGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDI 876
            ||||.:|:|:||.:...|:..|:|:|.:.. ::...:..||:|..|...|:|.:         ||
Zfish   821 DGGLTLLVPYLLTRRNRWKKSKIRVFVLGD-QETMQEDHKDMKMLLKRFRLEIE---------DI 875

  Fly   877 SAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTAS 941
                                          :|.|.:|        |..|.:.:  ..||.:....
Zfish   876 ------------------------------IVITDVD--------KPPLAKNL--QRYDDSVAPF 900

  Fly   942 KVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNV 1006
            ::      .||....|.|...:.|            |.|.|:||          ..:::|
Zfish   901 RL------TEEQSRGDLQEFRRLN------------PWTVSDKD----------LEAIRP----- 932

  Fly  1007 RRMHTAIKLNEVIVEKSQDAQLVIMNLPGP----PREVRAERERNYMEFLEVLTEGLE-KVLMVR 1066
             ::...::|||:|.:.|..|.||:::||.|    |..:       ||.::|.|:.|:. ..|::|
Zfish   933 -KIERTVRLNEIIKKNSNHAALVVVSLPVPDLNCPSSL-------YMAWMEALSFGIHCPALLIR 989

  Fly  1067 GGGREVITIY 1076
            |....|:|.|
Zfish   990 GNQENVMTFY 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	294/1140 (26%)
		SLC12	674..1077	CDD:281515	102/465 (22%)
slc12a10.3	XP_021333240.1	SLC12	54..1000	CDD:332077	295/1147 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750