DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and slc12a7a

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	XP_005171306.1	Gene:	slc12a7a / 558214	ZFINID:	ZDB-GENE-070912-696	Length:	1117	Species:	Danio rerio

Alignment Length:	1127	Identity:	568/1127 - (50%)
Similarity:	757/1127 - (67%)	Gaps:	92/1127 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KDDSDEMEIIPSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIA 71
            ::|.:|.|.....:.|  .||..|.|..|  :.::..|:...|:.||::::::.|.:|:.::.:|
Zfish    27 EEDKEEPETAAGHYPG--DETPRETSSLI--STDHDDSTYGKNMALYEEEMDSTPMVSSLLNKLA 87

  Fly    72 NYENTIPAATDPD--------AKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVC 128
            ||.|....|.:.:        .:......:|||.|||||||.|||.|||||:||||:|||||.:.
Zfish    88 NYTNITQGAVEHEEAESEDGIQRVTVNGPQMGTFIGVFLPCTQNILGVILFLRLTWIVGTAGILE 152

  Fly   129 GFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYI 193
            ...:|..||..|||||||||||||||||||||||:||||:||||.|||||:.||.|||.|.:|||
Zfish   153 ALAVVFMCCACTMLTAISMSAIATNGVVPAGGSYYMISRALGPEIGGAVGLCFYLGTTFAGSMYI 217

  Fly   194 VGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACV 258
            :|.:||.|||:.|.|::|.  ..:...|.||.|:|||..|..|.|:||:|||:|||.:.|.|:||
Zfish   218 LGTMEIFLTYIMPSAAVFE--ANNPTGMQNNMRIYGTCCLAIMTLVVFVGVKYVNKLSLVFLSCV 280

  Fly   259 ILSIIAVYVGIFDNIHGNEKLYMCVLGKRLL----KDIPLENCTKE---DSFLRDI-----YCPD 311
            :|||:|:|.|:..:........:|:||.|.|    |....:.|.|.   |:..:..     :| :
Zfish   281 VLSIMAIYAGVIQSAIKPSSFTICLLGNRTLQHFGKSGKFDKCMKTEVIDNITKPTELWYHFC-N 344

  Fly   312 GKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGE--------- 367
            |.|:||:..|.:|::..:.||.|....:|::..:   |::    ::.::.||.:.|
Zfish   345 GTCDEYFNLNELTEISAVPGLLSNAITENLWSRY---GEY----RTTVEKENITSEAALSSEPEV 402

  Fly   368 --SYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSV 430
              ||  ::.|:.|.||||:||:|||||||||||||||||.|.|:|||.|||.||.|||.:|:|.|
Zfish   403 LNSY--VVNDMATFFTLLVGIYFPSVTGIMAGSNRSGDLRDPQRSIPTGTIMAIATTSFIYISCV 465

  Fly   431 MFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIAR 495
            :.|....:.::||||:|.|:...||||.:|||:.|||:||||.|..||||||||||||:||||||
Zfish   466 VLFGACFEGVVLRDKYGDSVNKNLVVATLAWPSPWVIVIGSFFSCCGAGLQSLTGAPRILQAIAR 530

  Fly   496 DEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQT 560
            |.|:|||..|.:|...||||.|||||..||:.|||:.::|.:||:|||||||||.||||||||||
Zfish   531 DGIMPFLQVFGRSKSGGEPTWALLLTAAICEIGILIASLDAVAPILSMFFLMCYLFVNLACAVQT 595

  Fly   561 LLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGI 625
            |||||||||||||||||||.:|::|.:|:|.::|||:||:.:.:|..||||||||||.||||||:
Zfish   596 LLRTPNWRPRFKFYHWSLSFLGMSLSLSLMFVSSWYYALVVILIAGCIYKYIEYRGAVKEWGDGL 660

  Fly   626 RGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSV 690
            ||::|.||||:|::|||..|||||||||:|||.||:.:|..|:.::.||.:||||||||||..||
Zfish   661 RGLSLNAARYALIKLEEAQPHTKNWRPQLLVLMKLDTDLTVKHPRLLSFTSQLKAGKGLTIVCSV 725

  Fly   691 IKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGW 755
            ::|........|..|:..::..|..||.||||.|:|:....:|.|.:||:.||||||.|.|::.|
Zfish   726 LEGTFMVRGADAKLAEQNIKAAMAKEKTKGFCHVVVSSNQRDGFSHLIQSAGLGGMKHNAVLVAW 790

  Fly   756 PYSWRQ-EGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLML 818
            |.:|:| |...|||.||:|||...|.|.||:|.|.::.:|.:..::. |.||:||||||||||||
Zfish   791 PANWKQAESSLSWKNFIETVRETTAAHQALLVAKNVDTFPSNQDRLAEGTIDVWWIVHDGGLLML 855

  Fly   819 LPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYER 883
            |||||:||:.||.||:|||||||::||||||||||:.||||||::|.|||||||..||||:|||:
Zfish   856 LPFLLRQHKVWRKCKMRIFTVAQMDDNSIQMKKDLQMFLYHLRLDAKVEVVEMNAGDISAFTYEK 920

  Fly   884 TLMMEQRNQMLRALGLNKKENSKVVQTIMD------------YKETPSDNKMSLVQTIVDH---- 932
            ||:||||:|||:.:.|:|.|..:.:|:|.|            .|:| .::|:.:....:|.
Zfish   921 TLVMEQRSQMLKQMQLSKTEREREIQSISDESRISIRRKPCGEKQT-HNSKLKVATVNLDEEAQL 984

  Fly   933 -HYDATKT-ASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDF 995
             |...||: |:.|..|.||.:..  |.:...||     |.|..|       ..:|.|....|
Zfish   985 IHDKNTKSHATLVEKATPTSDRV--HMTWTKEK-----LIGERN-------RLRDASMHVRD--- 1032

  Fly   996 KSSVKP-----DEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVL 1055
            ..::||     |:.||||||||:|||||:|:||:.||||::|:||||:....  :.|||||||||
Zfish  1033 IFNMKPEWENLDQTNVRRMHTAVKLNEVVVKKSKGAQLVLLNMPGPPKNKGG--DENYMEFLEVL 1095

  Fly  1056 TEGLEKVLMVRGGGREVITIYS 1077
            ||||:.||:|||||||||||||
Zfish  1096 TEGLDHVLLVRGGGREVITIYS 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	556/1083 (51%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	211/427 (49%)
slc12a7a	XP_005171306.1	2a30	62..1117	CDD:273347	556/1086 (51%)
slc12a7a	XP_005171306.1	SLC12	704..1117	CDD:281515	212/432 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594146
Domainoid	1	1.000	431	1.000	Domainoid score	I565
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1166	1.000	Inparanoid score	I194
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm25212
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770