Protein Alignment kcc and slc12a2

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_001002080.1
• Gene: slc12a2 / 415170
• ZFINID: ZDB-GENE-040625-53
• Length: 1136
• Species: Danio rerio
• Alignment Length: 1167
• Identity: 297/1167 - (25%)
• Similarity: 477/1167 - (40%)
• Gaps: 326/1167 - (27%)

  Fly    46 IDPNLYLYDDDLETRPHISTFISSIANYENTIPAATDPDAKPAAPS---ARMGTLIGVFLPCIQN 107
            |.|.|....|:|:..|    |....||.|...| |.:..||..:.|   .:.|.:.||.:.|:.|
Zfish   161 IRPTLSELHDELDKEP----FEDGFANGEELTP-AEESAAKDVSESKGVVKFGWIKGVLVRCMLN 220

  Fly   108 IFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPE 172
            |:||:||||:||:||.||.....:||:....||.:|..|.|||||||.|..||:|::||||||||
Zfish   221 IWGVMLFIRMTWIVGQAGIAYSCIIVIMATVVTTITGCSTSAIATNGFVRGGGAYYLISRSLGPE 285

  Fly   173 FGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRVYGTLLLIFMG 237
            |||::|::|.....:|.|||:||..|.|:..:.....:..|.|       |:.||.||:.:|.:.
Zfish   286 FGGSIGLIFAFANAVAVAMYVVGFAETVVELLMDSGLLMIDQT-------NDIRVIGTITVILLL 343

  Fly   238 LIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDS 302
            .|...|:::..|.....|..:|.:|...::|.|..:...:|.
Zfish   344 GISVAGMEWEAKAQIFLLVILITAIFNYFIGSFIAVDSKKKF----------------------- 385

  Fly   303 FLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGE 367
                                     |.....:|:..:|..|.|  :||
Zfish   386 -------------------------GFFSYDAGILAENFGPDF--RGQ----------------- 406

  Fly   368 SYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMF 432
                       :|..:..||||:.|||:||:|.||||||.|.:||.||:.|||.|..||: .|..
Zfish   407 -----------TFFSVFSIFFPAATGILAGANISGDLADPQMAIPKGTLLAILITGLVYV-GVAI 459

  Fly   433 FAGTVDNLLLRD-------------------KFG-------QSIGGKLVVANIAWPNQW------ 465
            .||.   .::||                   |:|       .::.|::........|.:
Zfish   460 SAGA---CIVRDATGIESNFTLISNCTDAACKYGYDFSSCRPTVEGEVSSCKFGLHNDFQVMSVV 521

  Fly   466 -----VILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVI 524
                 :|..|.|.:||.:.|.||..||::.||:.:|.|.|.:|.|.|. .|..||.|...||..|
Zfish   522 SGFSPLISAGIFSATLSSALASLVSAPKVFQALCKDNIYPGIAIFGKGYGKNNEPLRGYFLTFGI 586

  Fly   525 CQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISV 589
            ....||:..::::||::|.|||..|..:|.:....:|..:|.|||.||:|:...||.|..||..|
Zfish   587 ALAFILIAELNVIAPIISNFFLASYALINFSVFHASLANSPGWRPSFKYYNMWASLAGAILCCVV 651

  Fly   590 MIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQI 654
            |.:.:|:.||:...:.:.:|.|:.|:..:..||...:.:....|....|:|.....|.|.:|||.
Zfish   652 MFIINWWAALLTNVIVLSLYIYVSYKKPDVNWGSSTQALTYHQALTHSLQLCGVADHIKTFRPQC 716

  Fly   655 LVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAK------ATLRKYM 713
            ||::...::.......:.:|...:    ||.:|      .|.:|:::..:.|      ...::::
Zfish   717 LVMTGAPNSRPAILHLVHAFTKNV----GLMLC------GHVRISSRRPNFKELNSDMLRYQRWL 771

  Fly   714 TDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVA 778
            .:...|.|...:||:.:.:|...::|..|||.::|||::||:...||.......:|:|..:....
Zfish   772 LNNNSKAFYTCVVAEDLRQGTQYMLQAAGLGRLRPNTLVIGFKNDWRIGDIKEVETYINLIHDAF 836

  Fly   779 ACHMALMVPK---------------------------------GINFYPES-------------- 796
            .....:::.:                                 |.:..|.|
Zfish   837 DFQYGVVILRLREGLDISHIQGQDDSSGMKDVVVSVDISKDSDGDSSKPSSKATSVQNSPAVQKD 901

  Fly   797 --------------------------------------NHKIG-GNIDIWWIVHDGGLLMLLPFL 822
                                                  ..|.| |.:|:||:..||||.:|:|:|
Zfish   902 EDDDGKAHTQPLLKKDKKSPTVPLNVADQRLLDASQQFQQKQGKGTVDVWWLFDDGGLTLLIPYL 966

  Fly   823 LKQHRTWRNCKLRIFTVAQIEDNSIQM-KKDLKTFLYHLRIE-ADVEVVEMNNSDISAYTYERTL 885
            :...:.|::||:|:|...:|  |.|.. ::.:.|.|...||: :|:.|:    .||
Zfish   967 IANKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSKFRIDFSDITVL----GDI--------- 1016

  Fly   886 MMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTI 950
                 |...::.||     ::..:.|..||....|.:.              :.|.|::..:|.
Zfish  1017 -----NTKPKSEGL-----TEFAEMIEPYKLREDDMEQ--------------EAAEKLKSEEPW- 1056

  Fly   951 EETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKL 1015
                                        ..|.|:.| ..||.|                :..|:|
Zfish  1057 ----------------------------RITDNELE-LYKAKG----------------NRQIRL 1076

  Fly  1016 NEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            ||::.|.|..|.|::|::|...:  .|.....||.:|:.|::.|..:|:|||..:.|:|.||
Zfish  1077 NELLKEHSSTANLIVMSMPLARK--GAVSSALYMAWLDTLSKDLPPILLVRGNHQSVLTFYS 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	293/1162 (25%)
		SLC12	674..1077	CDD:281515	95/496 (19%)
slc12a2	NP_001002080.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..121
		AA_permease_N	124..185	CDD:285588	9/27 (33%)
		2a30	138..1136	CDD:273347	295/1165 (25%)
		Intg_mem_TP0381	<573..677	CDD:295259	36/103 (35%)
		SLC12	726..1136	CDD:281515	95/506 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	875..921		3/45 (7%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594128
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850