Protein Alignment kcc and NKCC

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Alignment Length: 1238
• Identity: 286/1238 - (23%)
• Similarity: 492/1238 - (39%)
• Gaps: 352/1238 - (28%)

  Fly     2 QSNSAKDDSDEM--EIIPSEHNGTVHETKNEDSGDIHRAEE---------NQKSSIDPNLYLYDD 55
            ::.||:.|..:.  .:.|:.:...:|...:.::|:..|:..         .:||..:....|...
  Fly    21 EARSAESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSRLSFRGFGNFLRKSDAERKFSLAQL 85

  Fly    56 DLETRPHISTFISSIANYEN---------------TIPAATDPDAKPAAPSARMGTLIGVFLPCI 105
            ..|:.|.:..:..|:.|.:.               |||   :|:.:......::|.::||.:||:
  Fly    86 TKESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIP---EPEPEATGGHIKLGWIVGVLIPCL 147

  Fly   106 QNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLG 170
            .||:||:||:||:|||..:|.:...:|:.....|.::|.:|:|||:|||.|..||.||:||||||
  Fly   148 LNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLG 212

  Fly   171 PEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRVYGTLLLIF 235
            ||||.:||::|.....::|:|..:|..|.:...:.      .:..|..|...|:.|:.|::.::.
  Fly   213 PEFGASVGVVFAFANAVSASMNTIGFCESLNVLLK------NNDLKIVDNGINDIRIVGSITVLV 271

  Fly   236 MGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKE 300
            :.||..:|:::..|.....:..::|:|....:|......|||:...
  Fly   272 LILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQIS------------------- 317

  Fly   301 DSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTS 365
                                      :|..|.:.....:|.
  Fly   318 --------------------------RGFVGFSWATLKENF------------------------ 332

  Fly   366 GESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSV 430
            |..| :....:...|..:..|||||||||.||:|..|||.||..:||.||..::|.:.:.|...|
  Fly   333 GSDY-RYAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFV 396

  Fly   431 MFFAGTVDNLLLRDKFG---QSIGGKLV--------VANIAW-----------PNQW--VILIGS 471
            :|..|..    :||..|   ..:.|.:|        ..|..|           .:.|  :|..|.
  Fly   397 LFAGGAA----VRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGC 457

  Fly   472 FLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVD 535
            |.:||...|.:|...|||:||:..|:|.|.|..|:|. .|.|||.|..:||..|....:|:|.::
  Fly   458 FAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELN 522

  Fly   536 LLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALI 600
            |:|||:|.|:|..|..:|........::...|||.||:|:..|||.|..:|:::|.:.::..|:|
  Fly   523 LIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAII 587

  Fly   601 AMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLL 665
            ..|:...:|..:.||..|..||...:.....||..::.||:....|.||:.||:||||  .|
  Fly   588 TFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLS--GD--- 647

  Fly   666 PKYR-KIFSFATQLKAGKGLTICVSVI--KGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVA 727
            ||.| .:..|...|.....|....::|  :..:....:...|.    :||:...|:|.|.:|:..
  Fly   648 PKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNRQHLVKDG----QKYLDARKIKAFYNVIDG 708

  Fly   728 QQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMA---LMVPKG 789
            ..:.:|::::.::.|.|.|.||.|::|:...|.:..:...:::...:....:..|.   |.:|.|
  Fly   709 FSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNG 773

  Fly   790 INF-----------------------------YPESN---------------------------- 797
            ::|                             .|.:|
  Fly   774 LDFSELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQ 838

  Fly   798 --------------------------HKIGGN---------------------IDIWWIVHDGGL 815
                                      |..||:                     ||::|:..||||
  Fly   839 PAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGL 903

  Fly   816 LMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYT 880
            .:|||:::.....|:|.|||:|.:...:|.. |.:|.:.:.|...||:
  Fly   904 TILLPYIISMRSHWQNSKLRVFAMCHGKDEE-QEEKSMASLLTKFRIK----------------- 950

  Fly   881 YERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRF 945
            |...:|::..::..||            .|::.:|                            |.
  Fly   951 YSELIMLKGVSEQPRA------------DTVLKHK----------------------------RL 975

  Fly   946 ADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMH 1010
            .:|.....::.....|::..|:                 .|.|.:
  Fly   976 IEPFRRGARNEFGITDDELQSM-----------------SEKTNR-------------------- 1003

  Fly  1011 TAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLE-KVLMVRGGGREVIT 1074
             .::::|::|:.|.:|.||:|:||.|.:|  |.....||.:||:||..:: .|.:.||....|:|
  Fly  1004 -QLRIHELVVKHSSNASLVVMSLPMPRKE--AISAPLYMSWLEMLTSDMKCPVALARGNQTPVLT 1065

  Fly  1075 IYS 1077
            :||
  Fly  1066 LYS 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	275/1178 (23%)
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	274/1172 (23%)