Protein Alignment kcc and nkcc-1

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_001255790.1
• Gene: nkcc-1 / 3565648
• WormBaseID: WBGene00012543
• Length: 1235
• Species: Caenorhabditis elegans
• Alignment Length: 1302
• Identity: 312/1302 - (23%)
• Similarity: 498/1302 - (38%)
• Gaps: 427/1302 - (32%)

  Fly     3 SNSAKDDSDEMEIIPSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLY-LYDDDLET-----RP 61
            |.|..:|.||...|..|:..|.:          .::..|.|:...|.:. .|.:.::|     ||
 Worm   134 SGSMSEDGDEKRNITHENQTTFN----------MKSWRNMKTIEHPPIIDFYRNSIDTDGVFNRP 188

  Fly    62 HISTFISSIANYENTI---------------PAATDPD--------AKPAAPSARMGTLIGVFLP 103
            .::..|....:.|..:               |.....:        |.|:....:.|.:.|||:.
 Worm   189 SMAQLIHGKEHKEQDLGFEELNAQHHHLEDSPVHETKNEYRMEKMHAPPSQNRVKFGWIQGVFVR 253

  Fly   104 CIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRS 168
            |:.|||||:|::|::||.|.||...|..|||....||.:||:|..||.|||.|..||:||:||||
 Worm   254 CLLNIFGVMLYLRVSWVSGQAGVGLGSCIVLLASVVTTITALSTCAICTNGDVKGGGAYFLISRS 318

  Fly   169 LGPEFGGAVGMLFYTGTTLAAAMYIVGAVE----IVLTYMAPWASIFGDFTKDADAMYNNFRVYG 229
            |||||||::|::|.....:.|||||||..|    :::.|..  .:||       |....:.||.|
 Worm   319 LGPEFGGSIGIIFSIANAVGAAMYIVGFAESFRDVLIDYNI--GTIF-------DGGLWDVRVIG 374

  Fly   230 TLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPL 294
            .:..:.:..|||:|.:|.:|. .:.|..::|..||.|                |.|
 Worm   375 FVTCVILMGIVFIGSEFESKM-QLGLLVILLVSIANY----------------VFG--------- 413

  Fly   295 ENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAI 359
                                 .::..|.:...:|..|.:......|..|.|.|...|.|
 Worm   414 ---------------------SFFPPNEIAMNRGATGYSLDTLQSNFMPHFTENNTFFS------ 451

  Fly   360 DIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTST 424
                                   :..::||:.||||||:|.|||||:.|::||:||:.|||.|:.
 Worm   452 -----------------------VFSVYFPAATGIMAGANISGDLANPQQAIPLGTLLAILVTTI 493

  Fly   425 VYL-------SSVMFFAGTVDNLLLRDK------------FGQSIGGKLVVANIAW-PNQWVILI 469
            |||       |:|:.|:...:..:..:.            ||.....::|..:..| |   :|..
 Worm   494 VYLLTVWMTGSTVVAFSNGTEPAVFNNSYFVPPDCTPDCPFGLVSYYQVVEMSSFWGP---LITA 555

  Fly   470 GSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGN 533
            |.|.:||.:.|.||..||::.||:.:|.:.|.:..|||: .|..||.||.:|...:....:.:|:
 Worm   556 GIFAATLSSALASLVSAPKVFQAVCKDRLFPRIDYFAKTYGKNEEPKRAYVLGFFLAMGIVAIGD 620

  Fly   534 VDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFA 598
            ::::||::|.|||..|..:|.||..|:...:|.:||.|.:|:..:||:|..||:.||.:..|:.|
 Worm   621 LNVIAPIISNFFLGSYALINYACFDQSFADSPGFRPGFTYYNMWISLVGALLCVFVMFIIDWFSA 685

  Fly   599 LIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDN 663
            |:.......|:.|:.:|..:..||...:..:...|..::::|.....|.||:|||:||||   .|
 Worm   686 LVTFFCFGAIFMYLLHRKPDVNWGSSTQAHSYKNALSAMIKLSTTEEHVKNYRPQVLVLS---GN 747

  Fly   664 LLPKYRK-IFSFATQLKAGKGLTICVSVI---KGDHTKITNKAVDAKATLRKYMTDEKVKGFCDV 724
              |..|. :..||..:..|..|.:|..|:   ..|...:..|.:|  ..:..::....:|.|...
 Worm   748 --PASRSCLVDFANNITKGSSLLVCGQVVPYEPSDRVYMVMKRLD--ENINVWLRKRHLKAFYRA 808

  Fly   725 LVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEG-----RNSWKTFIQTVRTVAACHMAL 784
            :......:|..|:||..|:..||||.|::|:..:|.:.|     .|....:..|::.|...:||:
 Worm   809 VANSNFRKGAQSLIQLTGIAKMKPNIVLMGFKSNWYKGGPTETNLNEMNEYFGTIQDVFDWNMAM 873

  Fly   785 MVPK----GINF---------------------------------YPESNHKI------------ 800
            .|.:    |::|                                 .||:.|.|
 Worm   874 CVLRNGQVGLDFSEAMRNLNLIEPNRLNVPPIEEKEKEKEKTNENSPETVHLIEKDETARTDKSG 938

  Fly   801 ----------------------------------------------------------------- 800
                                                                             
 Worm   939 DDGSSARLSYRGSCRSVEMFQRINAFYINASISINETYVSDENQEDADGDDDNDNDGEESGADDE 1003

  Fly   801 -------------------------------------------------GGNIDIWWIVHDGGLL 816
                                                             .|.||:||:..||||.
 Worm  1004 HQKEDDVELGVIDEQEKRHFSLRRRGSRRHTVEQKALLSSIQRFNRKVKKGTIDVWWLYDDGGLT 1068

  Fly   817 MLLPFLLKQHRTW-RNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYT 880
            :|:|.||...::: ...:|||||::                                       |
 Worm  1069 LLIPHLLAIPKSYLEGARLRIFTIS---------------------------------------T 1094

  Fly   881 YERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRF 945
            ..||:..|||.  :.||....:.:...|..|.|..:.|....|:..|:::
 Worm  1095 SSRTMEQEQRG--MAALLSKFRIDYSDVYVIADIGKKPRQETMNTWQSVI--------------- 1142

  Fly   946 ADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMH 1010
             ||.|.:                 ||    ..|...:.|.|.:.:.|..::.
 Worm  1143 -DPFIAQ-----------------DG----SCPIGMTTKSELSAQRDKTYRQ------------- 1172

  Fly  1011 TAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITI 1075
              ::..|::.|.|.:|.|::|.||.|.:.:.:  ...||.:|||:|..|..||:|||..:.|:|.
 Worm  1173 --LRAGELLNEHSINADLIVMTLPVPRKGMVS--SSLYMSWLEVMTRNLPPVLLVRGNQQSVLTF 1233

  Fly  1076 YS 1077
            ||
 Worm  1234 YS 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	299/1254 (24%)
		SLC12	674..1077	CDD:281515	100/574 (17%)
nkcc-1	NP_001255790.1	2a30	165..1235	CDD:273347	300/1259 (24%)
		SLC5-6-like_sbd	<323..686	CDD:294310	124/450 (28%)
		SLC12	751..1235	CDD:281515	101/580 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920