DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and CG10413

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001286048.1	Gene:	CG10413 / 35111	FlyBaseID:	FBgn0032689	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	1091	Identity:	275/1091 - (25%)
Similarity:	435/1091 - (39%)	Gaps:	304/1091 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DPDAKPAAPSAR-MGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAI 145
            |||.     |.| :||..|||.|...::|..::|||:.::||.||.....|..|....:.:.|..
  Fly    57 DPDR-----SGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVA 116

  Fly   146 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWAS- 209
            |:.||:|||.:..||.||||||:||.||||::|.||:....:.:||.|.|..|.::....|...
  Fly   117 SVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFGPRGHF 181

  Fly   210 IFGD-FTKDAD-------AMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVY 266
            :.|| ...|.|       :|.|..::          |:..:|.....|.:.:.||.|.:.:.|.|
  Fly   182 VSGDSHLPDGDWWRFLTSSMINTLQL----------LVCLVGAALFAKTSVIILATVTVCLFATY 236

  Fly   267 VGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYL--ANNVTKVKGI 329
            .                                  |||             ::  .||...|.|
  Fly   237 F----------------------------------SFL-------------FVGATNNTIPVPG- 253

  Fly   330 KGLASGVFYDNIFPSFLEKGQFISY-GKSAIDIENTSGESY------NQIMADITTSFTLLIGIF 387
                     |||..:   ...|:.| |.:|..:.:..|..|      |....|.:|:|    |:.
  Fly   254 ---------DNILSN---TTTFLDYTGLNATTLRDNLGSHYGRDYTSNGKQVDFSTTF----GVL 302

  Fly   388 FPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTT--STVYLSSVM-----FFAGTVDNLLLRDK 445
            |..|||||||:|.||:|.:..||||.||:.|:..|  |.:.||.:|     :|  |:.|..|
  Fly   303 FSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYF--TMQNNYL--- 362

  Fly   446 FGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFA-KSS 509
                   .|:..|: ||.  ...||...:|....|.:|.|:.|:|:|:::|::...|..|. ..:
  Fly   363 -------FLMPVNL-WPP--FTAIGILTATFSTSLSNLIGSSRILEALSKDQVFGSLLNFVIHGT 417

  Fly   510 KRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFY 574
            .:|.|..|:.::..:.:|.:|:|:.:::|.:.|:.|::.|...||||....|...||:||.|||:
  Fly   418 WKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFF 482

  Fly   575 HWSLSLIGLTLCISVMIMTSWYFA----LIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARY 635
            .|...|:||...:.:|.:.::.:|    ::.:.:.|.::.:.....| .:||...:.:.....|.
  Fly   483 TWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQA-AQWGSISQALMFHQVRK 546

  Fly   636 SLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITN 700
            .||.|:....|.|.||||||:|.....:..|    :..|...||. .||.|...|..||...|.
  Fly   547 YLLMLDPRKDHVKFWRPQILLLVSSPRSCCP----LVDFVNDLKK-SGLYIIGHVKLGDFKGIE- 605

  Fly   701 KAVDAKATLR--KYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGW-----PYS 758
               ||:...:  .::...:||.|.:|.:::.|.||:..:|:..|:|.|||||:|:|:     |..
  Fly   606 ---DAEDNQQWWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYDSEAPRD 667

  Fly   759 WRQEGRNSWKT--------------------------FIQTV-------RTVAACHMALMVPKGI 790
            :.|.|.:.:||                          ::|.:       :.:..|.....:.|
  Fly   668 FFQNGSSPYKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRLDK-- 730

  Fly   791 NFYPESNHKIGGNIDIWWI---------VHDGGLLMLLPFLLKQHRTWRNCKLRIF--------T 838
            ||...|.|.  ..||:|.|         ..|...|.::...:.....|::.::|||        |
  Fly   731 NFISMSKHV--KYIDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFLCEANDERT 793

  Fly   839 VAQIEDNSIQM----KKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGL 899
            |...:..:.||    |..|:..|..|||.||:..::..:.|.....:.|||
  Fly   794 VGTFDTQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFSRHARTL-------------- 844

  Fly   900 NKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKR 964
                                  |....|                  ||..:.|
  Fly   845 ----------------------KQFTAQ------------------ADNVVLE------------ 857

  Fly   965 NSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLV 1029
                    ::.:..|.|.|:                    ::..|..|   |::|.|:|....|.
  Fly   858 --------DDDEVGEETLNR--------------------SLLYMQRA---NQIIRERSDQTALS 891

  Fly  1030 IMNLPGPPREVR---AERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            .:.|..||:...   |:|..:|||.|..||..|...::|.|    |.|:.|
  Fly   892 FIYLAAPPKLSAPDFAQRSASYMELLTELTADLPPTILVHG----VSTVTS 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	274/1089 (25%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	98/466 (21%)
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	271/1079 (25%)
CG10413	NP_001286048.1	SLC12	577..932	CDD:281515	96/464 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467892
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20017at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950