Protein Alignment kcc and Slc12a7

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_063144456.1
• Gene: Slc12a7 / 308069
• RGDID: 1359672
• Length: 1179
• Species: Rattus norvegicus
• Alignment Length: 1094
• Identity: 565/1094 - (51%)
• Similarity: 746/1094 - (68%)
• Gaps: 88/1094 - (8%)

  Fly    30 EDSGDIHRAEENQKSSID-PNLYLYDDDLETRPHISTFISSIANYEN----TIPAATDPDAKPAA 89
            |:|..|:..|..::|..: .|:.|:::::::.|.:|:.::.:|||.|    .:....|.|::...
  Rat    80 ENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEDSRRRE 144

  Fly    90 PSA-RMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATN 153
            ..| ||||.|||:|||:|||.|||||:||||:||.||.:..||||..||..||||||||||||||
  Rat   145 IKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVAMCCTCTMLTAISMSAIATN 209

  Fly   154 GVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKD- 217
            |||||||||:|||||||||||||||:.||.|||.|.||||:|.:||.|||::|.|:||...|.|
  Rat   210 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADG 274

  Fly   218 -ADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYM 281
             |.|:.||.||||:..|..|.::||:|||:|||.|.|.||||:|||:|:|.|:.........:.:
  Rat   275 EAAALLNNMRVYGSCALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPV 339

  Fly   282 CVLGKRLLKDIPLENCTKED--------SFLRDIYCP----DGKCEEYYLANNVTKVKGIKGLAS 334
            |:||.|.|.:...:.|.|..        :.|..::|.    ...|:||::.||||:::||.|:||
  Rat   340 CLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLGASCDEYFVQNNVTEIQGIPGVAS 404

  Fly   335 GVFYDNIFPSFLEKGQFI-SYGKSAIDIENTS---GESYNQIMADITTSFTLLIGIFFPSVTGIM 395
            |||.||::.::.:||.|: ..|.|::.:...|   |..|  ::.||.|.||:|:||:||||||||
  Rat   405 GVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPY--VLTDIMTYFTMLVGIYFPSVTGIM 467

  Fly   396 AGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIA 460
            |||||||||.|||||||.|||.||:|||.:|||.::.|...::.::||||||:::.|.||:..:|
  Rat   468 AGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLA 532

  Fly   461 WPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVIC 525
            ||:.|||:||||.||.||||||||||||||||||||.|||||..|......||||.|||||.:||
  Rat   533 WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALIC 597

  Fly   526 QCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVM 590
            :.|||:.::|.:||:|||||||||.||||||||||||||||||||||||||:||.:|::||:::|
  Rat   598 ETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALM 662

  Fly   591 IMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQIL 655
            .:.|||:||.||.:|..||||||||||||||||||||::|.||||:|||:|.|||||||||||:|
  Rat   663 FICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVL 727

  Fly   656 VLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKG 720
            |:..|:.....|:.::.||.:||||||||||..||::|.:.....:|..|:..:|..|:.||:||
  Rat   728 VMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHVEAQRAEENIRSLMSAEKMKG 792

  Fly   721 FCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-EGRNSWKTFIQTVRTVAACHMAL 784
            ||.::|:..:.:|.|.:||:.||||||.|||::.||.:|:| :...|||.|:.|||...|.|.||
  Rat   793 FCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEAWKQADNPFSWKNFVDTVRDTTAAHQAL 857

  Fly   785 MVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQ 848
            :|.|.|:.:|::..:.. ||||:||||||||:||||||||:||:.||.|::|||||||::|||||
  Rat   858 LVAKNIDLFPQNQERFSDGNIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQ 922

  Fly   849 MKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMD 913
            |||||:.|||||||.|:||||||..:||||:|||:|||||||:|||:.:.|:|.|..:..|.|.|
  Rat   923 MKKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHD 987

  Fly   914 YKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTP 978
             :.|.|       .|:.....:|..|..||:.            :...||.            ..
  Rat   988 -RNTAS-------HTVATARTEAPPTPDKVQM------------TWTKEKL------------IA 1020

  Fly   979 ETTSNKDESTEKADGDFKS--SVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVR 1041
            |...|||..|    ..||.  |:|||:.||||||||:|||.|::.||||||||::|:||||:..:
  Rat  1021 EKHRNKDTGT----SGFKDLFSLKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKSRQ 1081

  Fly  1042 AERERNYME-FLEVLTEG---------------------LEKVLMVRGGGREVI 1073
            .:......: ||.|:...                     |.|.:|..||||:.:
  Rat  1082 GDENCILFQCFLVVVVNSITTIDTVRPDLSCSQSLNSCELGKTVMGVGGGRQTV 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	560/1074 (52%)
Slc12a7	XP_063144456.1	None