Protein Alignment kcc and vhc1

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_001342720.1
• Gene: vhc1 / 2540830
• PomBaseID: SPBC18H10.16
• Length: 1050
• Species: Schizosaccharomyces pombe
• Alignment Length: 1173
• Identity: 286/1173 - (24%)
• Similarity: 484/1173 - (41%)
• Gaps: 292/1173 - (24%)

  Fly    39 EENQKSSI----DPNLYLYDDDLETRPHISTFISSIANYENTIPAATDPDAKPAAPSARMGTLIG 99
            :||.:||.    :|......:.....|.:|   .|:...||..|          ..:.::||..|
pombe    31 QENLESSTPLLQEPQQSYRSNSFNELPPLS---RSVTFAENEQP----------NEAVKLGTFEG 82

  Fly   100 VFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFM 164
            .|:|...|:..::|::|..|::|.||.:...|::.....|.:.|::|:|||.|||:|..||:|:.
pombe    83 CFIPTTLNVLSILLYLRFPWIIGEAGVLKTLLMLFISYAVGIFTSLSISAICTNGMVRGGGAYYA 147

  Fly   165 ISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAM-------Y 222
            :|||:|||.||::|::||.|..|...|.|.|.||       |..||||   |::..:       |
pombe   148 VSRSIGPELGGSIGLIFYVGQILNTGMNISGFVE-------PIISIFG---KESGTISQFLPEGY 202

  Fly   223 NNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYV-GIFDNIHGNEKLYMCVLGK 286
            ....:|.|.:|....::..||.....|.:......:|||.|::.: .||  :|
pombe   203 WWVFLYTTCVLAMCCILCCLGSAIFAKASNALFVVIILSTISIPISSIF--VH------------ 253

  Fly   287 RLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQF 351
                  |.    |:.|.|                               |.:..:..|.|.|...
pombe   254 ------PF----KDPSLL-------------------------------VHFTGLKWSTLMKNLA 277

  Fly   352 ISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTI 416
            .:|      .||..|..|.        ||....|:|||:..|::||::.||||....:|||.|||
pombe   278 SAY------TENEKGTGYE--------SFKSTFGVFFPATAGLLAGASMSGDLKAPSRSIPKGTI 328

  Fly   417 CAILTTSTVYLSSVMFFAGTVDN---LLLRDKFGQ-SIGGKLVVANIAWPNQWVILIGSFLSTLG 477
            .:..||..:||..::....:|..   ||..|.... |:....:::.|       :..|:|.|.:|
pombe   329 SSQATTFLLYLLVILCVGASVTRTGLLLDMDVMEHISLHPLFIISGI-------LSSGAFSSFMG 386

  Fly   478 AGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGE-PTRALLLTIVICQCGILLGNVDLLAPLL 541
                 :.||.:||||||||::||.:..|||.|...: |..|:.:|.:|.|.. |..::::|:.::
pombe   387 -----IFGAAKLLQAIARDDLIPGMFFFAKGSSYDDIPYVAIGVTYLITQIS-LFWDINMLSSMI 445

  Fly   542 SMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAI 606
            :|.||:.:||:||:|.:..:..|||:||.|::::...:|:|..|...||.......|.|:..:|.
pombe   446 TMTFLLTFGFINLSCFLLRISSTPNFRPTFRYFNRRTTLVGTILSFGVMFYVDRLNAFISFLIAG 510

  Fly   607 IIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKI 671
            |:...|.:....|.|||..:|:.....|..||:..:...:.|.||||||:|.. |.|   :...:
pombe   511 ILVVVIYFTCPPKNWGDVSQGIIYHQLRKYLLQTNKARENIKFWRPQILLLIN-NPN---RSENV 571

  Fly   672 FSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKAT---LRK-------YMTDEKVKGFCDVLV 726
            ..|...||.| .|.|...||..|         |.:|:   |||       ::.|..:|.|.::.:
pombe   572 IRFCNSLKKG-SLYILGHVIVSD---------DFQASMDDLRKQQRLWHQFVLDRGIKAFVELTI 626

  Fly   727 AQQIGEGLSSVIQTIGLGGMKPNTVII--------------GWPYSW----RQEGRNSWKTF--- 770
            |.....|:..:|.:.||||::||..::              |..:|.    .:...:|.|.|
pombe   627 APDEVWGIRGLISSAGLGGIRPNIAVLTFINTNYRRHRIYSGSSFSLENTSEESESDSKKEFVEH 691

  Fly   771 -------IQTVRTVAACHMALMVPKG---------------INFYPESNHKIGG----------- 802
                   :|.:..:....:.:||..|               |:.:|  .|:|.|
pombe   692 DILPVKWVQILEDMLVGSVDVMVTNGFDRLNWPKRKGEKQYIDMFP--IHRISGVGSEVNESTPT 754

  Fly   803 ---NIDIWWIVHDGGLLMLLPFLLKQHRTWR-NCKLRIFTVAQIEDNSIQMKKD-----LKTFLY 858
               |.:.:.:|..      |.::|.....|: .|:||:.|:.:.| |.|:.:::     |:||
pombe   755 FATNFETYTMVFQ------LSWILHTASDWKQGCRLRLITLVEFE-NEIEAERESMHQMLETF-- 810

  Fly   859 HLRIEADVEVVEMNNSDISAYTY--ERTLMMEQRNQMLRAL-------GLNKKENSKVVQTI--- 911
              ||:|||.|:.:...::.||.|  :...:...::..|..|       ...||.....|.::
pombe   811 --RIKADVVVLCLAAMNLDAYRYIVKNEHVRPSKSSELENLLKDDSWWQEEKKRRGNTVDSLGPI 873

  Fly   912 ---------------MDYKETPSDNKMSL-----VQTIVDHHYDAT--------KTASKVRFADP 948
                           .|....|....:|.     :.::.....:::        |..::..::|.
pombe   874 RFPRRMSGYNFRSASFDKSAPPLSVPLSFRLGPHMHSVKSFETESSFGNRSLSPKQENRRTYSDS 938

  Fly   949 TIEET-----QHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRR 1008
            |||.:     ...||.:|..             .|:....:|.|.||...:..||        |.
pombe   939 TIESSLMPNVVREDSSSDRL-------------APKKKIGRDYSKEKLTFNDLSS--------RS 982

  Fly  1009 MHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRA--ERERNYMEFLEVLTEGLEKVLMVRGGGRE 1071
            .:  |.:||::::.:::..::...||.|..:...  .:...|::.|.:..|||....::......
pombe   983 QY--IIMNEIVLKHTKNTSVLFTVLPAPLADTHKSFRKSEEYVDDLLIFMEGLPPCALIHSKSLT 1045

  Fly  1072 VIT 1074
            :.|
pombe  1046 ITT 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	281/1159 (24%)
vhc1	NP_001342720.1	AA_permease_2	57..818	CDD:459263	241/892 (27%)