Protein Alignment kcc and Slc12a1

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_001257546.1
• Gene: Slc12a1 / 25065
• RGDID: 3685
• Length: 1095
• Species: Rattus norvegicus
• Alignment Length: 1217
• Identity: 311/1217 - (25%)
• Similarity: 493/1217 - (40%)
• Gaps: 370/1217 - (30%)

  Fly    39 EENQKSSIDPNLYLYDDDLETRPHISTF-------ISSIANYENT-------------------- 76
            :..:.:..|...:.||....|. ::.||       :..|..|.||
  Rat    71 QTGETAKTDTTFHAYDSHTNTY-YLQTFGHNTMDAVPKIEYYRNTGSVSGPKVNRPSLQEIHEQL 134

  Fly    77 ------IPAATD----PDAKPAAPSA-----------RMGTLIGVFLPCIQNIFGVILFIRLTWV 120
                  .|.:.|    .|..|....|           :.|.:.||.:.|:.||:||:|||||:|:
  Rat   135 AKNVAVAPGSADRVANGDGMPGDEQAENKEEDVTGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWI 199

  Fly   121 VGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGT 185
            ||.||...|.||:|....||.:|.:|.|||||||.|..||:|::|||||||||||::|::|....
  Rat   200 VGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFAN 264

  Fly   186 TLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMY----NNFRVYGTLLLIFMGLIVFLGVKF 246
            .:|.|||:||..|.|:           |..|::|:|.    |:.|:.|::.::.:..|...|:::
  Rat   265 AVAVAMYVVGFAETVV-----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEW 318

  Fly   247 VNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPD 311
            ..|...:.|..::::|...::|..                     ||
  Rat   319 EAKAQVILLVILLIAIANFFIGTV---------------------IP------------------ 344

  Fly   312 GKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADI 376
                    :||..|.:|.....:.:|.:|..|||                  |.||.:..:.|
  Rat   345 --------SNNEKKSRGFFNYQASIFAENFGPSF------------------TEGEGFFSVFA-- 381

  Fly   377 TTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLL 441
                     ||||:.|||:||:|.||||.|.|.:||.||:.||..|:..|:...:..|..|
  Rat   382 ---------IFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACV---- 433

  Fly   442 LRDKFGQS----IGGKLVVANIAW------------PNQW-----------------VILIGSFL 473
            :||..|..    :.|.....:.|.            |.|:                 :|..|.|.
  Rat   434 VRDATGSMNDTVVSGMNCNGSAACGLGYDFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFS 498

  Fly   474 STLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVDLL 537
            :||.:.|.||..||::.||:.:|.|...|..|||. .|..||.|...||.||....||:..::::
  Rat   499 ATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVI 563

  Fly   538 APLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAM 602
            ||::|.|||..|..:|.:|...:..::|.|||.:..|:..:||.|..||.:||.:.:|:.|:|..
  Rat   564 APIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITY 628

  Fly   603 GMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPK 667
            .:.:.:|.|:.|:..:..||...:.::..:|..:.|.|.....|.||:|||.:||:.     .|.
  Rat   629 VIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTG-----GPM 688

  Fly   668 YR-KIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIG 731
            .| .:...........||.||..|..|.......:.....|..:.::...|:|.|...:.|....
  Rat   689 TRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLMKNKIKAFYAAVAADCFR 753

  Fly   732 EGLSSVIQTIGLGGMKPNTVIIGWPYSWR------------------------------------ 760
            :|:.|::|..|||.|||||::||:..:||
  Rat   754 DGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDIS 818

  Fly   761 ----------------------------QEGRNSWKTFIQ----------------TVRTVAACH 781
                                        :||:...:...:                .:.|:.:.|
  Rat   819 PVLQVQDELEKLEQERLALEAAIKDNDCEEGKGGIRGLFKKAGKLNITKPAPKKDSNISTIQSMH 883

  Fly   782 MALMVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFT---VAQI 842
            :.....|.:....:...|.| |.||:||:..||||.:|:|::|...:.|::|||||:.   :.:|
  Rat   884 VGEFNQKLVEASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRI 948

  Fly   843 EDNSIQMKKDLKTFLYHLRIE-ADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSK 906
            |:..|.|...|..|    ||: ||:.::    .||:...                    .||:.|
  Rat   949 EEEKISMASLLSKF----RIKFADIHII----GDINIKP--------------------NKESWK 985

  Fly   907 VVQTIMD-YKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLD 970
            |.:.::: |:             :.:.|.|.| ||.|:                   ||.|
  Rat   986 VFEEMIEPYR-------------LHESHKDLT-TAEKL-------------------KRES---- 1013

  Fly   971 GPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPG 1035
             |......|..:.|::|                      :..::|||::.|.|:.|.|::::||
  Rat  1014 -PWKITDAELEAVKEKS----------------------YRQVRLNELLQEHSRAANLIVLSLP- 1054

  Fly  1036 PPREVRAERERN-----YMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
                  ..|:.:     ||.:||:||:.|..||:|||..:.|:|.||
  Rat  1055 ------VARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	308/1205 (26%)
		SLC12	674..1077	CDD:281515	105/493 (21%)
Slc12a1	NP_001257546.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..45
		AA_permease_N	86..152	CDD:285588	10/66 (15%)
		2a30	100..1095	CDD:273347	303/1185 (26%)
		SLC12	690..1095	CDD:281515	106/499 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750