Protein Alignment kcc and Slc12a7

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_006517233.1
• Gene: Slc12a7 / 20499
• MGIID: 1342283
• Length: 1117
• Species: Mus musculus
• Alignment Length: 1081
• Identity: 580/1081 - (53%)
• Similarity: 759/1081 - (70%)
• Gaps: 73/1081 - (6%)

  Fly    30 EDSGDIHRAEENQKSSID-PNLYLYDDDLETRPHISTFISSIANYEN----TIPAATDPDAKPAA 89
            |:|..|:..|..::|..: .|:.|:::::::.|.:|:.::.:|||.|    .:....|.|::...
Mouse    77 ENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEDSRRRE 141

  Fly    90 PSA-RMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATN 153
            ..| ||||.|||:|||:|||.|||||:||||:||.||.:..||||..||..||||||||||||||
Mouse   142 VKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMCCTCTMLTAISMSAIATN 206

  Fly   154 GVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKD- 217
            |||||||||:|||||||||||||||:.||.|||.|.||||:|.:||.|||::|.|:||...|.|
Mouse   207 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADG 271

  Fly   218 -ADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYM 281
             |.|:.||.||||:..|..|.::||:|||:|||.|.|.||||:|||:|:|.|:.........:.:
Mouse   272 EAAALLNNMRVYGSCALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPV 336

  Fly   282 CVLGKRLLKDIPLENCTKED--------SFLRDIYCPDGK----CEEYYLANNVTKVKGIKGLAS 334
            |:||.|.|.:...:.|.|..        :.|..::|....    |:||:..||||:::||.|:||
Mouse   337 CLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLGATCDEYFAQNNVTEIQGIPGVAS 401

  Fly   335 GVFYDNIFPSFLEKGQFI-SYGKSAIDIENTS---GESYNQIMADITTSFTLLIGIFFPSVTGIM 395
            |||.||::.::.:||.|: ..|.|::.:...|   |..|  ::.||.|.||:|:||:||||||||
Mouse   402 GVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPY--VLTDIMTYFTMLVGIYFPSVTGIM 464

  Fly   396 AGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIA 460
            |||||||||.|||||||.|||.||:|||.:|||.::.|...::.::||||||:::.|.||:..:|
Mouse   465 AGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLA 529

  Fly   461 WPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVIC 525
            ||:.|||:||||.||.||||||||||||||||||||.|||||..|......||||.|||||.:||
Mouse   530 WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALIC 594

  Fly   526 QCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVM 590
            :.|||:.::|.:||:|||||||||.||||||||||||||||||||||||||:||.:|::||:::|
Mouse   595 ETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALM 659

  Fly   591 IMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQIL 655
            .:.|||:||.||.:|..||||||||||||||||||||::|.||||:|||:|.|||||||||||:|
Mouse   660 FICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVL 724

  Fly   656 VLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKG 720
            |:..|:.....|:.::.||.:||||||||||..||::|.:.....:|..|:..:|..|:.||.||
Mouse   725 VMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHVEAQRAEENIRSLMSAEKTKG 789

  Fly   721 FCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-EGRNSWKTFIQTVRTVAACHMAL 784
            ||.::|:..:.:|.|.:||:.||||||.|||::.||.:|:: :...|||.|:.|||...|.|.||
Mouse   790 FCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEAWKEADNPFSWKNFVDTVRDTTAAHQAL 854

  Fly   785 MVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQ 848
            :|.|.|:.:|::..:.. ||||:||||||||:||||||||:||:.||.|::|||||||::|||||
Mouse   855 LVAKNIDLFPQNQERFSDGNIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQ 919

  Fly   849 MKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMD 913
            |||||:.|||||||.|:||||||..:||||:|||:|||||||:|||:.:.|:|.|..:..|.|.|
Mouse   920 MKKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHD 984

  Fly   914 YKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTP 978
             :.|.|             |..||....    |.||.::.|.  :...||
Mouse   985 -RNTAS-------------HTTATARTQ----APPTPDKVQM--TWTKEK--------------- 1014

  Fly   979 ETTSNKDESTEKADGDFKS--SVKP-----DEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGP 1036
             ..:.|..:.:.....||.  |:||     |:.||||||||:|||.|::.||||||||::|:|||
Mouse  1015 -LIAEKHRNKDTGPSGFKDLFSLKPEWGNLDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGP 1078

  Fly  1037 PREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            |:.  .:.:.|||||||||||||.:||:|||||||||||||
Mouse  1079 PKS--RQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	573/1059 (54%)
Slc12a7	XP_006517233.1	AA_permease_2	74..1117	CDD:459263	578/1079 (54%)