Protein Alignment kcc and Slc12a3

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_017168114.1
• Gene: Slc12a3 / 20497
• MGIID: 108114
• Length: 1009
• Species: Mus musculus
• Alignment Length: 1180
• Identity: 293/1180 - (24%)
• Similarity: 483/1180 - (40%)
• Gaps: 320/1180 - (27%)

  Fly     9 DSDEMEIIPSE--HNGTVH-ETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHIS---TFI 67
            ||.:    ||.  |..|:: .|...::.|:..|.|:..:|..|.     :..:.||.::   :|:
Mouse    36 DSSQ----PSHLTHGSTLYMRTFGYNTIDVVPAYEHYANSALPG-----EPRKVRPTLADLHSFL 91

  Fly    68 SSIANYENTI-----------------PAATDPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFI 115
            ....::.:.:                 ...|:.:..|..| .|.|.:.||.:.|:.||:||||::
Mouse    92 KQEGSHLHALAFDGRQGRELTDGLVEDETGTNSEKSPGEP-VRFGWVKGVMIRCMLNIWGVILYL 155

  Fly   116 RLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGML 180
            ||.|:...||.|..:||:|....||.:|.:|:|||:|||.|.:||:||:||||||||.||::|::
Mouse   156 RLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLI 220

  Fly   181 FYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVK 245
            |.....:..||:.||..|.|...:....|...::........|:.|:.|.:.:..:..|...|::
Mouse   221 FAFANAVGVAMHTVGFAETVRDLLQLACSPTQEYGTPIVDPINDIRIIGVVTVTVLLAISLAGME 285

  Fly   246 FVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCP 310
            :.:|...:....:::|.....||..                     ||    ..||...:..|..
Mouse   286 WESKAQVLFFLVIMVSFANYLVGTL---------------------IP----ASEDKASKGFYSY 325

  Fly   311 DGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMAD 375
            .|   :.::.|.|...:||.|...|:|
Mouse   326 HG---DIFVQNLVPDWRGIDGSFFGMF-------------------------------------- 349

  Fly   376 ITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNL 440
                     .|||||.|||:||:|.||||.|...:||.||:.||..|:..||:    .:.|:.:.
Mouse   350 ---------SIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLA----ISATIGSC 401

  Fly   441 LLRDKFGQ----SIGGKLVVANIAWPNQW------------------------------VILIGS 471
            ::||..|.    ...|......:|....|                              :|..|.
Mouse   402 VVRDASGDVNDTMTPGPGPCEGLACGYGWNFTECSQQRSCRYGLINYYQTMSMVSAFAPLITAGI 466

  Fly   472 FLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVD 535
            |.:||.:.|..|..|.::.|.:..|::.|.:..|.|. .|..||.|..||...|....|::..::
Mouse   467 FGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNREPVRGYLLAYAIAVAFIIIAELN 531

  Fly   536 LLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALI 600
            .:||::|.|||..|..:|.:|...::..:|.|||.|::|....:|.|..:.:.:|.:.:|:.|||
Mouse   532 TIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALI 596

  Fly   601 AMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLL 665
            |:|:.:.:..|:.|:..|..||..::..:...|....:.|.|...|.||:|||.|||:.     .
Mouse   597 AIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTG-----P 656

  Fly   666 PKYR-KIFSFATQLKAGKGLTICVSVIKG--------------DHTKITNKAVDAKATLRKYMTD 715
            |.:| .:..|.:.......|.||..|:.|              .|||..||
Mouse   657 PNFRPALVDFVSTFTQNLSLMICGHVLIGPGKQRVPELRLIASGHTKWLNK-------------- 707

  Fly   716 EKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVR----- 775
            .|:|.|...::|:.:..|:..::|..|||.||||.:::|:..:|:.....:.:.:|..:.
Mouse   708 RKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKRNWQSAHPATVEDYIGVLHDAFDF 772

  Fly   776 TVAACHMALMVPKGIN-----------------------FYPESNHKIGGNIDIWWIVHDGGLLM 817
            ....|.|.:.  :|:|                       |..|...|   .|||:|:..||||.:
Mouse   773 NYGVCVMRMR--EGLNVSEALQTHTTPEALIQEEQASTIFQSEQGKK---TIDIYWLFDDGGLTL 832

  Fly   818 LLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYE 882
            |:|:||.:.:.|..||:|:|...||.    :|.::.|..:
Mouse   833 LIPYLLHRKKRWGKCKIRVFVGGQIN----RMDEERKAII------------------------- 868

  Fly   883 RTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFAD 947
             :|:.:.|      ||.::      |..:.|..:.|.          .:|    ||     ||.|
Mouse   869 -SLLSKFR------LGFHE------VHVLPDINQKPQ----------AEH----TK-----RFED 901

  Fly   948 PTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDEST---EKADGDFKSSVKPDEFNVRRM 1009
             .|...:.:|                        ..|||:|   .:.|..:|  :..:|.|..|:
Mouse   902 -MIAPFRLND------------------------GFKDEATVTEMRRDCPWK--ISDEEINKNRI 939

  Fly  1010 HT--AIKLNEVIVEKSQDAQLVIMNLP----GP-PREVRAERERNYMEFLEVLTEGLE-KVLMVR 1066
            .:  .::|:|::::.|:||.|:|:.||    |. |..:       ||.:||.|::.|. .||::|
Mouse   940 KSLRQVRLSEILLDYSRDAALIILTLPIGRKGKCPSSL-------YMAWLETLSQDLRPPVLLIR 997

  Fly  1067 GGGREVITIY 1076
            |....|:|.|
Mouse   998 GNQENVLTFY 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	281/1137 (25%)
Slc12a3	XP_017168114.1	2a30	57..1008	CDD:273347	286/1155 (25%)