Protein Alignment kcc and Slc12a1

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_030104745.1
• Gene: Slc12a1 / 20495
• MGIID: 103150
• Length: 1154
• Species: Mus musculus
• Alignment Length: 1342
• Identity: 325/1342 - (24%)
• Similarity: 517/1342 - (38%)
• Gaps: 461/1342 - (34%)

  Fly     3 SNSAKDDSDEMEI-IPSEHNGTVHETKNEDSGDIHRAEENQ---------KSSIDP-NLYLYDDD 56
            |||....:...:: :.:|.:|:....  .||.|....||..         :.|..| |...||:.
Mouse     7 SNSVPSSASRFQVHVINEGHGSAAAV--GDSADPPHYEETSFGDEAQNRLRISFRPGNQECYDNF 69

  Fly    57 LET-------------RPHISTF-------ISSIANYENT------------------------- 76
            |:|             ..|.:|:       :..|..|.||
Mouse    70 LQTGETAKTDTTFHAYDSHTNTYYLQTMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVT 134

  Fly    77 -IPAATD----PDAKPAAPSA-----------RMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAG 125
             .|.:.|    .|..|....|           :.|.:.||.:.|:.||:||:|||||:|:||.||
Mouse   135 VAPGSADRVANGDGMPGDEQAENKEEDMTGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAG 199

  Fly   126 ---------------------------------------------------------AVCGF--- 130
                                                                     |..||
Mouse   200 IGLGVIIIGLAVTVTAITGLSTSAIATNGYVRGGLGVLIILLSTMVTSITGLSTSAIATNGFVRG 264

  Fly   131 ----LIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAM 191
                :|:.....||.||.||||||.|||||..||:|::|||||||||||::|::|.....:|.||
Mouse   265 GLGVIIIGLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAM 329

  Fly   192 YIVGAVEIVLTYMAPWASIFGDFTKDADAMY----NNFRVYGTLLLIFMGLIVFLGVKFVNKFAT 252
            |:||..|.|:           |..|::|:|.    |:.|:.|::.::.:..|...|:::..|...
Mouse   330 YVVGFAETVV-----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQV 383

  Fly   253 VALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEY 317
            :.|..::::|...::|..                     ||
Mouse   384 ILLVILLIAIANFFIGTV---------------------IP------------------------ 403

  Fly   318 YLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADITTSFTL 382
              :||..|.:|.....:.:|.:|..|||                  |.||.:..:.|
Mouse   404 --SNNEKKSRGFFNYQASIFAENFGPSF------------------TKGEGFFSVFA-------- 440

  Fly   383 LIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFG 447
               ||||:.|||:||:|.||||.|.|.:||.||:.||..|:..|:...:..|..|    :||..|
Mouse   441 ---IFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACV----VRDATG 498

  Fly   448 QSIGGKLV---------VANIAW--------PNQW-----------------VILIGSFLSTLGA 478
             |:...:|         ...:.:        |.|:                 :|..|.|.:||.:
Mouse   499 -SMNDTIVSGMNCNGSAACGLGYDFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSS 562

  Fly   479 GLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVDLLAPLLS 542
            .|.||..||::.||:.:|.|...|..|||. .|..||.|...||.||....||:..::::||::|
Mouse   563 ALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIIS 627

  Fly   543 MFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAII 607
            .|||..|..:|.:|...:..::|.|||.:..|:..:||.|..||.:||.:.:|:.|:|...:.:.
Mouse   628 NFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELF 692

  Fly   608 IYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYR-KI 671
            :|.|:.|:..:..||...:.::..:|..:.|.|.....|.||:|||.:||:.     .|..| .:
Mouse   693 LYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTG-----GPMTRPAL 752

  Fly   672 FSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSS 736
            ...........||.||..|..|.......:.....|..:.::...|:|.|...:.|....:|:.|
Mouse   753 LDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRS 817

  Fly   737 VIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALM---VPKGINFYP---- 794
            ::|..|||.|||||::||:..:||:...:..:.::..:.......:.::   :.:|.:..|
Mouse   818 LLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQV 882

  Fly   795 --------------------------------------------------------------ESN 797
                                                                          |.|
Mouse   883 QDELEKLEQERLALEAAIKDNECEEGKGGIRGLFKKAGKLNITKPAPKKDGNISSIQSMHVGEFN 947

  Fly   798 HKI------------GGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFT---VAQIEDNSI 847
            .|:            .|.||:||:..||||.:|:|::|...:.|::|||||:.   :.:||:..|
Mouse   948 QKLVEASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKI 1012

  Fly   848 QMKKDLKTFLYHLRIE-ADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTI 911
            .|...|..|    ||: ||:.::    .||:...                    .||:.||.:.:
Mouse  1013 SMASLLSKF----RIKFADIHII----GDINIKP--------------------NKESWKVFEEM 1049

  Fly   912 MD-YKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENA 975
            :: |:             :.:.|.|.| ||.|:                   ||.|     |...
Mouse  1050 IEPYR-------------LHESHKDLT-TAEKL-------------------KRES-----PWKI 1076

  Fly   976 DTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREV 1040
            ...|..:.|::|                      :..::|||::.|.|:.|.|::::||
Mouse  1077 TDAELEAVKEKS----------------------YRQVRLNELLQEHSRAANLIVLSLP------ 1113

  Fly  1041 RAERERN-----YMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
             ..|:.:     ||.:||:||:.|..||:|||..:.|:|.||
Mouse  1114 -VARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	311/1283 (24%)
		SLC12	674..1077	CDD:281515	103/493 (21%)
Slc12a1	XP_030104745.1	2a30	96..1154	CDD:273347	304/1249 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750