DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and kcc-1

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001293846.1	Gene:	kcc-1 / 177495	WormBaseID:	WBGene00006504	Length:	1156	Species:	Caenorhabditis elegans

Alignment Length:	1100	Identity:	453/1100 - (41%)
Similarity:	659/1100 - (59%)	Gaps:	137/1100 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAATDPDAKPAAPS-- 91
            |:|:|..|            ||.|:::  .:.|..|:::.          |...|.....|.|
Worm   137 NKDAGGNH------------NLALFEE--PSMPFFSSYLK----------AHITPGPLERAQSSS 177

  Fly    92 -------ARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSA 149
                   |.:|.|:||:||.||:|.||.:||||.|:||.||....||::..||..|.||.||:||
Worm   178 HGGHGAKADLGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQTFLLLFLCCFCTFLTCISISA 242

  Fly   150 IATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPW------- 207
            :||||||.:||:||||||:||||||.|||:|||...|:|.:||:||.|||:|.|:.|.
Worm   243 VATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGVE 307

  Fly   208 ----ASIFGDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYV- 267
                .|:||..|       |:.|.|.|:||:....||.:|||||...|.|:|.||||||:|.|.
Worm   308 GQHDTSMFGTMT-------NSLRFYSTILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAG 365

  Fly   268 GIFDNIHGNEKLYMCVLGKRLL-------KDIPLEN----CTKEDSFLRDIYCPDGKCEEYYLAN 321
            |:...|:.:...|:|:...|||       :.|||:.    |...::||.|..| .|:|      |
Worm   366 GVTKTIYPDSGQYVCMYNDRLLQSSAVLNESIPLDEICNYCNINNTFLADRVC-GGRC------N 423

  Fly   322 NVT--------KVKGIKGLASG-VFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADIT 377
            :.|        .:.|..|...| ...:|:.|::||||: .::|        |..::.:.:..|:.
Worm   424 STTIPHVSPFRCINGFPGFQGGQTLLENLGPNYLEKGE-AAHG--------TQADTKSDVYQDVR 479

  Fly   378 TSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLL 442
            |||.:|:.|:||:||||..|:|.||||.:.|.|||.|||.|.||||.||.|....|.|.:||.:|
Worm   480 TSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAIDNAVL 544

  Fly   443 RDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAK 507
            |||.|||:||::|||.::||:.||:||||||||.||.||.|..|||||||||:||:||.|:||.|
Worm   545 RDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKK 609

  Fly   508 SSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFK 572
            .:...||...|:||.:|.:..||:|::|.:|.::..||||||.|||:.|.:.:||..||||||||
Worm   610 VTANNEPFLGLILTTIIAEIAILMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAPNWRPRFK 674

  Fly   573 FYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSL 637
            :|||.|||:|..||..:|..|.|.:|::|..:.::||||:|::||:|||||||||:|||.|:|||
Worm   675 YYHWFLSLLGAVLCFFIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSL 739

  Fly   638 LRLEEGPPHTKNWRPQILVLSKL---NDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKIT 699
            :::|:..||.||||||:|:|..:   .:.:..:|..:.:.|:|||||||||:..:.::||.|...
Worm   740 MKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNLASQLKAGKGLTVVTAFLQGDPTSPD 804

  Fly   700 N--KAVDAKATLRKYMTDEKVKGFCDVLV--AQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWR 760
            :  |....||.:...|...:::||...||  ..|:...:|:::|::||||:||||::|.||...|
Worm   805 DKKKGEQVKARMDFDMNQVRLRGFAKTLVHSEDQVRGSMSTLVQSVGLGGLKPNTMLISWPVHER 869

  Fly   761 QEGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQ 825
            :|....:.|||:.|...:...||::|.|||..:|.:..::.|.||::||||||||.:|:.:||||
Worm   870 EEDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPSAVFRMSGMIDVYWIVHDGGLCLLMGYLLKQ 934

  Fly   826 HRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQR 890
            |:.||.||||:..:||..||:::|::||:.::|.|||:|.:.:||:.:.:||...:||||:||:|
Worm   935 HKVWRGCKLRVIGIAQESDNNVKMQEDLQKYVYQLRIDAKIMIVELADPEISKNAFERTLLMEER 999

  Fly   891 NQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQH 955
            ..|:|.|       .||           |...|||          :...|:..|...|.:
Worm  1000 TMMMRDL-------QKV-----------SGGGMSL----------SLPPANAPRAPSPLV----- 1031

  Fly   956 HDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKP------DEFNVRRMHTAIK 1014
               .::.:.||.|.|.....::.|||..|..||:....:.::..|.      |...|.:||||::
Worm  1032 ---TSERRANSKDSDEGTPTESEETTEKKSTSTDNEQANQETKTKKERMKALDRSKVSKMHTAVR 1093

  Fly  1015 LNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVIT 1074
            |||::::.|.::||:::|||.||.....:...:|:.:|||:|:.|.:|:.|||.|:||||
Worm  1094 LNELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLNRVIFVRGTGKEVIT 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	448/1079 (42%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	148/410 (36%)
kcc-1	NP_001293846.1	2a30	166..1153	CDD:273347	441/1045 (42%)
kcc-1	NP_001293846.1	SLC12	776..1153	CDD:281515	147/412 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.890