DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and kcc-2

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001255279.2	Gene:	kcc-2 / 177370	WormBaseID:	WBGene00019205	Length:	1129	Species:	Caenorhabditis elegans

Alignment Length:	1146	Identity:	515/1146 - (44%)
Similarity:	730/1146 - (63%)	Gaps:	118/1146 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SNSAKDDSDEMEIIPSEHNGTVHETKNEDSGDI--HRAEENQKSSI------DPNLY-------- 51
            ||.|.:.:.:.||....|:.....|.:..:..:  .|:.....|.:      .||::
Worm    31 SNLAVNSATKKEITNKAHDFEPEPTSSTSTNTVTSRRSSGGSGSGLGPASKKPPNMHINIPTDEG 95

  Fly    52 --------------LYDDDLETR-PHISTFISSIANYENTIPAATDPDAKPAAPSARMGTLIGVF 101
                          ||:.|.:|: ..|.|.:..::.|..|...:.:.|.||.|.:|:|||::|||
Worm    96 AERIPLCEQHSPLALYEQDYDTQGQKIGTMLRKLSVYNATEATSVEADEKPKAAAAKMGTIMGVF 160

  Fly   102 LPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMIS 166
            |||:||||||:.||||.|::||||....|.:||||..||.||:||:||||||||||:||.|:|||
Worm   161 LPCLQNIFGVLFFIRLAWIIGTAGVFQAFFVVLTCVSVTFLTSISLSAIATNGVVPSGGPYYMIS 225

  Fly   167 RSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRVYGTL 231
            |:||||.|||||:|||.|||:||:|||.||:||:|.|:.|.|.:|.|       :|:||||.||:
Worm   226 RNLGPELGGAVGILFYLGTTIAASMYITGAIEILLLYIYPQAKLFDD-------IYHNFRVLGTV 283

  Fly   232 LLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLE- 295
            ||:.:||||..||||||:.|...:..|||.|::..:|:|....|::.|..|::|.|     |::
Worm   284 LLLILGLIVMAGVKFVNRCALPLVIVVILCILSAILGVFVRYDGSDSLKFCMVGDR-----PVDL 343

  Fly   296 -----------NCTKEDSFLRDIYC-PDGKCEEYYLANNVTKV------------KGIKGLASGV 336
                       |||.:.  |:|::| .:|.|:.||......||            :.|||:||||
Worm   344 STYFEKTQVQPNCTADG--LQDLFCSTNGTCDHYYDRMKNIKVWKSSGMPAIREERAIKGIASGV 406

  Fly   337 FYDNIFPSFLEKGQFISYG-KSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNR 400
            |:||::|.:|..|:.:|.. |...|:......||  |.|:..|:|.:|:|:||||.|||||||||
Worm   407 FFDNLWPKYLRAGEVLSKDRKDKGDLNRGGHPSY--IYAESVTNFMILVGVFFPSATGIMAGSNR 469

  Fly   401 SGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQW 465
            ||:|.||.||||:||:.|...:|.:||..|:.|..:|..:.:|||:|:|..|||:::.|:||...
Worm   470 SGNLRDAAKSIPLGTLAAQNFSSFIYLLGVVLFGASVSEMFIRDKYGRSAMGKLIISEISWPFPQ 534

  Fly   466 VILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGIL 530
            |||.|.|:||.|||:||||||||||||||.|:::|||.||.|...||||.||:|||:.||:||||
Worm   535 VILFGCFMSTAGAGMQSLTGAPRLLQAIAADDVLPFLKPFRKMDSRGEPIRAILLTLAICECGIL 599

  Fly   531 LGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSW 595
            :..::.:..|::.||||||..||.|||:|:||::|.|||.|:::|||||:||..||::||.:::|
Worm   600 IAVIENITALITQFFLMCYLGVNAACALQSLLKSPGWRPGFRYFHWSLSMIGAILCVAVMFISAW 664

  Fly   596 YFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLS-- 658
            :|||.|:.:...:||||||.|||||||||:||:.|:|||::||.|::.|.|::|||||:|||:
Worm   665 HFALFAIIIGAGVYKYIEYAGAEKEWGDGLRGLGLSAARFALLNLDDKPQHSRNWRPQLLVLAPD 729

  Fly   659 --KLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGF 721
              ..|.|      .|.||.:|||||||||:....::|::.....||...:..|:..:...|:|||
Worm   730 VESANTN------GILSFVSQLKAGKGLTLVAHCMEGEYADNYLKAQAVQEKLKAVVKKNKIKGF 788

  Fly   722 CDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSW---KTFIQTVRTVAACHMA 783
            |||||...:.||:|.::||.|||||:.|||::.||..|:.|  ..|   ..|:..:|.::|...|
Worm   789 CDVLVTSNVIEGISCLVQTSGLGGMRHNTVVLSWPNDWKAE--QEWVVANKFVSAIRAISAAKCA 851

  Fly   784 LMVPKGINFYPESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQ 848
            :||||....:|.:..|:.|.||:||:||||||||||||||:||:||:|..:|:|.:||:|||::|
Worm   852 IMVPKYAEKFPANGTKVSGFIDVWWVVHDGGLLMLLPFLLRQHKTWKNTTVRLFAIAQMEDNNVQ 916

  Fly   849 MKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMD 913
            ||.||:.|||||||:|.|.|:||.:||||.||||||:.||:|||.|:  .|||.:..|.:|..::
Worm   917 MKTDLEKFLYHLRIDAAVNVIEMTDSDISDYTYERTMKMEERNQYLK--NLNKSDRDKDIQNHLE 979

  Fly   914 YKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTP 978
            .  ...:.|:|.:      :.:|.....:.|..:...||.:...|:|...:  |:..|...:|
Worm   980 I--VTRERKLSRI------NEEAPAVVPEQRNLEVVDEEQEDGKSENGSAK--IEHKGVRFSD-- 1032

  Fly   979 ETTSNKDESTEKA-------DGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGP 1036
                  ||.:::.       :.|.:...:...:||.:||||:||||::.:||.|||||.:|||||
Worm  1033 ------DEDSKEVKVGNGTLERDREERQRKRRYNVHKMHTAVKLNELMRQKSSDAQLVFVNLPGP 1091

  Fly  1037 PREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            |   .|:.:..||:|:|.|||||::||:|||.|.||:||||
Worm  1092 P---DADSDSYYMDFIEALTEGLDRVLLVRGTGAEVVTIYS 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	503/1090 (46%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	177/412 (43%)
kcc-2	NP_001255279.2	2a30	144..1129	CDD:273347	493/1031 (48%)
kcc-2	NP_001255279.2	SLC12	741..1129	CDD:281515	177/412 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159054
Domainoid	1	1.000	357	1.000	Domainoid score	I508
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21056
Inparanoid	1	1.050	970	1.000	Inparanoid score	I153
Isobase	1	0.950	-	0	Normalized mean entropy	S2108
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		oto19467
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3041
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890