DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and kcc-3

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001338828.1	Gene:	kcc-3 / 174212	WormBaseID:	WBGene00019289	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	1123	Identity:	436/1123 - (38%)
Similarity:	644/1123 - (57%)	Gaps:	150/1123 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IPSEHNGTVHETKNEDSGDIHRAEENQKSSID-PNLYLYDDDLETRPHISTFISSIANYENTIPA 79
            ||:::.|                  |:|.:.. .:|.||.:|    ..|.|..|.|:.|
Worm    48 IPADYKG------------------NRKFTTSLGHLALYKED----EGIGTQASFISGY------ 84

  Fly    80 ATDPDAKPAAPS----ARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVT 140
             |.|..|..|.|    |.:|.::||:||.||:|.||.:||||.||||.:|......::..||..|
Worm    85 -TTPGPKERATSEHVKANLGVMLGVYLPTIQHILGVTMFIRLFWVVGMSGVAWTMALLAICCLST 148

  Fly   141 MLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMA 205
            :||:||:||:||||||.:||:||:|||:||.|||.|||:|||...|:||:|||||.||::|.|:.
Worm   149 LLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLANTVAASMYIVGGVEVILMYLW 213

  Fly   206 PWASIFG-DFTKDAD---AMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVY 266
            |..:|.| |...|.:   ::|||.|:|||:.|:...|||.:|||||...|.|:|.||||:|.|..
Worm   214 PEMAIGGADALHDTEMFGSLYNNLRLYGTVFLLIQALIVAMGVKFVQLLAPVSLMCVILAIAACI 278

  Fly   267 VGIFDNIHGNEKLYMCVLGKRLLKD------------------IPLENCTKEDSFLRDIYCPDGK 313
            .|..:.....|.:.:|.:...||:.                  :...|...:..:|..::|.:..
Worm   279 GGGIEKQITMEGMKVCAIDNHLLQSSIVTHPIHKNQTSWFNETVDFCNLCDKSLYLESVFCANVN 343

  Fly   314 CEE----------YYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGES 368
            .:|          :|.:..:|......|.......||::|.::||.:.         :....|:.
Worm   344 NDEASAEDDVFCTHYTSKKMTCQLAFPGFNMKTLNDNMWPEYMEKSEV---------VPGVRGKE 399

  Fly   369 YNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFF 433
            ..:::.|.:::|.:|:.|:||:||||..|:|.||||.|.|:|||:|||.|.||||.:|....:.|
Worm   400 TAEVVQDESSTFFMLMAIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATLTTSAIYYILAILF 464

  Fly   434 AGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEI 498
            .|::...:||||||:|||..:|||.::||:..|:.:|:||||.||.||.|..||||||:||:|::
Worm   465 GGSITRSVLRDKFGRSIGNTMVVAALSWPHPAVVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDV 529

  Fly   499 IPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLR 563
            ||.|||||:.:|..||...|:||::|.:||||||.||.:|.:|..||||||.||||...:.::|:
Worm   530 IPILAPFARVTKNNEPFLGLVLTVIIAECGILLGAVDKIAEVLDFFFLMCYAFVNLIAVLHSVLK 594

  Fly   564 TPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGM 628
            :||||||||::||:|||:|..||..:|..:|...|.||.....:||||:|::||:||||||:||:
Worm   595 SPNWRPRFKYFHWTLSLLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGL 659

  Fly   629 ALTAARYSLLRLEEGPPHTKNWRPQILVL--SKLNDNLLPKYR-KIFSFATQLKAGKGLTICVSV 690
            |||.|:||||::|:..||.||||||:|:|  |:.:..::.:.. .:.:...|||||:||.|..:.
Worm   660 ALTTAQYSLLKVEDKDPHPKNWRPQVLILLTSQWSKEMIDRRAVSMLNLGAQLKAGRGLAIACAF 724

  Fly   691 IKG--DHTKITNKAVDAKATLRKYMTDEKVKGFCDVLV--AQQIGEGLSSVIQTIGLGGMKPNTV 751
            :||  |..|..|:|.|.|.||.|.|:..:::||...:.  ..||...:|.:.|:||:||::|||:
Worm   725 LKGSVDSQKDKNRARDVKTTLVKDMSSVRLRGFAKTMFYNNHQINGTISGLYQSIGIGGLRPNTI 789

  Fly   752 IIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIGGNIDIWWIVHDGGLL 816
            ::.||   .::..:....|.:.:...||....|:|.|||..:||.:.::.|.|||||||.|||:|
Worm   790 LLNWP---NEKNPDELVLFAEEIIHGAANDNCLIVTKGITDFPEYSERLTGFIDIWWIVQDGGIL 851

  Fly   817 MLLPFLLKQHRTWRNCKLRIFTVA-QIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYT 880
            ||:.:||:||:.|:.|.||||.|: |....|..||..|:.::|.|||:|::.:|::.:.::|...
Worm   852 MLIAYLLRQHKVWKGCTLRIFAVSEQDSTKSEDMKAGLQKYIYMLRIDAELFIVDLLDMEVSDEV 916

  Fly   881 YERTLMME----QRNQMLRALG--LN---KKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDA 936
            .|:...:|    :|.:|.|:..  ||   .::|.|..|.:|                   .|.|:
Worm   917 VEKAAEVERKQKEREEMRRSKSGYLNDGFMEDNGKPRQVMM-------------------RHSDS 962

  Fly   937 TKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKP 1001
            .::.|....|..:|                       |.|..||:     .||....||..|..|
Worm   963 ARSFSPQPGAHTSI-----------------------NLDETETS-----FTESLFDDFYRSGTP 999

  Fly  1002 DE-------FNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGL 1059
            :|       .|:.:|:|:::||.||.|.|.|:||:::|||.|||. |.....:||.:|:||||.|
Worm  1000 NEDLEGAMKLNIHKMNTSVRLNRVIRENSPDSQLILLNLPSPPRN-RLAFNNSYMTYLDVLTEDL 1063

  Fly  1060 EKVLMVRGGGREVITIYS 1077
            .:||.:.|.|||||||.|
Worm  1064 PRVLFIGGSGREVITIDS 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	430/1087 (40%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	146/423 (35%)
kcc-3	NP_001338828.1	SLC12	61..1081	CDD:332077	430/1090 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2108
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.740