DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and F10E7.9

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_495469.2	Gene:	F10E7.9 / 174167	WormBaseID:	WBGene00017350	Length:	603	Species:	Caenorhabditis elegans

Alignment Length:	585	Identity:	145/585 - (24%)
Similarity:	232/585 - (39%)	Gaps:	172/585 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 GTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAG 159
            ||..|||...:.||||:|:|:||.|:|||||.....|::..|..:.::|..|...|.....:.:|
Worm    48 GTWDGVFATVMVNIFGIIVFLRLGWIVGTAGVANSILLLGICTSLALITVFSAIGIVERCQIKSG 112

  Fly   160 GSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGD-----FTKDAD 219
            |.||::|..||.:.|||:|:::..|..:|..:..||               ||:     |..::.
Worm   113 GIYFLVSHVLGHQIGGAIGIIYAFGQAVATGLVAVG---------------FGESVAHLFESESK 162

  Fly   220 AMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVG--IFDNIHGNEKLYMC 282
            .|.....:   |.|:.:..:...||.:|     |.|..|:|..||:.|.  ||..:..:|
Worm   163 IMIKGIAI---LTLMVLTAVNTAGVTWV-----VRLQIVLLLTIALAVTDFIFGALFSSE----- 214

  Fly   283 VLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLE 347
                                       |:                      ||||
Worm   215 ---------------------------PE----------------------SGVF---------- 220

  Fly   348 KGQFISYGKSAIDIENTSGESYNQIMADI--------TTSFTLLIGIFFPSVTGIMAGSNRSGDL 404
              :|     |:..|...:...|..:...|        ..||..:.|:||.:..|::||.|.||||
Worm   221 --RF-----SSERIRVNADSHYEAVNCSIIGIPRQIPEQSFFTVFGVFFANFLGVLAGVNMSGDL 278

  Fly   405 ADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNL-LLRDKFGQSIGGKLVVANIAWPNQWVIL 468
            .|..||||:|.:.|:..:||:....:|...|..|.: ||.|..   |..|:.:..|      |.|
Worm   279 KDPHKSIPLGELSAVGVSSTICFIFIMILGGVGDRMFLLCDVM---ISEKVALTGI------VFL 334

  Fly   469 IGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLG 532
            :|.::.:|.:.:.||.|.||:||.||.:.|||.|...|:. .....|..|..|.:.:....:|||
Worm   335 VGLYVCSLSSTVGSLLGTPRVLQGIAEEGIIPCLNVLARGVGPNDNPVLAGYLLMGVASLFVLLG 399

  Fly   533 NVDLLAPLLSMFFLMCYGFVNL----------------ACAVQT--------------------- 560
            :::.||.|.:|.||:.|.:||.                |..|:|
Worm   400 DLNQLAILSTMPFLITYAYVNYSYVSLAMSYDLATVQHADEVETVGYGSTNKMNDLNELFPERRD 464

  Fly   561 -------------LLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYI 612
                         :.:...|...|...:  :|.:|..:.::::::..::||:......|.:|.||
Worm   465 VNITSTEETETGIISQEATWYSMFSNRY--VSFLGFLVNLAILLLIHFWFAVAHFVALIALYWYI 527

Fly 613 612
Worm 528 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	145/585 (25%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515
F10E7.9	NP_495469.2	2a30	47..>557	CDD:273347	145/585 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810