Protein Alignment kcc and Slc12a9

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_599232.2
• Gene: Slc12a9 / 171443
• RGDID: 620747
• Length: 914
• Species: Rattus norvegicus
• Alignment Length: 865
• Identity: 235/865 - (27%)
• Similarity: 382/865 - (44%)
• Gaps: 179/865 - (20%)

  Fly    89 APSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATN 153
            |.:.::.|.:||.:|.:.::|.:::|:|:.:|||.||.:....::|....:..||.:|:.|||||
  Rat    32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYVILALTVLSVCAIATN 96

  Fly   154 GVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFG-DFT-- 215
            |.|..||:||||||:||||.||::|::||.......|:.::|.||.:|       .:|| |.|
  Rat    97 GAVRGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESIL-------DVFGADVTGS 154

  Fly   216 ---KDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNK--FATV-----ALACVILSIIAVYVGIF 270
               |.....|....:||:|||..:|.:..||.....:  |.|.     :||.|::|.:||
  Rat   155 SGIKVLPQGYGWNLLYGSLLLGLVGGVCALGAGLYARASFLTFLLVSGSLASVLVSFVAV----- 214

  Fly   271 DNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKV--KGIKGLA 333
                          |.|                                  |:|..  .|..|
  Rat   215 --------------GPR----------------------------------NITLAPRPGTNG-- 229

  Fly   334 SGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADITT----SFTLLIGIFFPSVTGI 394
                 .::.|   ..|.|..:..|.  :::..|..|.:   |.||    :|..:..:.|...|||
  Rat   230 -----SSVPP---RHGHFTGFNGST--LKDNLGAGYAE---DYTTGAMMTFASVFAVLFNGCTGI 281

  Fly   395 MAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAG--TVDNLLLRDKFG--QSIGGKLV 455
            |||:|.||:|.|..::||:|||.|:..|..:|:  ::||..  |.|..||:..:|  :.|.
  Rat   282 MAGANMSGELKDPSRAIPLGTIIAVAYTFFIYI--LLFFLSSFTCDRALLQGDYGFFRDIS---- 340

  Fly   456 VANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEII-PFLAPFAKSSKRGEPTRALL 519
                .||.  ::|||.:.:.|.|.:.||.||.|:|.|:|:|::. ..|||....|..|.|..|:|
  Rat   341 ----LWPP--LVLIGIYATALSASMSSLIGASRILHALAQDDLFGVILAPAKVVSGGGNPWGAVL 399

  Fly   520 LTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLT 584
            .:..:.|..:|.|.::.||.::::|:|:.|..|:|:|........||:||.|..:.|...|:|:.
  Rat   400 YSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVA 464

  Fly   585 LCISVMIMTSWYFA---LIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPH 646
            .|:.:|.:.|...|   |:.||   ::...:..||....||...:.:.....|..||||:....|
  Rat   465 SCLLMMFLISPGAAGGSLLLMG---LLSALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKEH 526

  Fly   647 TKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRK 711
            .|.||||:|:|.......||..|    .|.|||.| ||.:...|..||...:.:..|..:.....
  Rat   527 VKFWRPQLLLLVGNPRGALPLLR----LANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWL 586

  Fly   712 YMTD-EKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGW------------------PY 757
            .:.| .:||.|.|:.::..:.:|...:::..|||||||||:::|:                  |.
  Rat   587 SLVDLAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPA 651

  Fly   758 SWRQEGRN-------------------SWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIGG- 802
            ...:||.:                   |.:.::.||......:..:::.:.....|......|.
  Rat   652 EGTREGGSPALSTLFPPPRAPGSPRALSPQDYVATVADALKMNKNVVLARACGALPPERLSRGSG 716

  Fly   803 ------NIDIW------------WIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQM 849
                  ::|:|            ::...|..|:.:..:|.....|.:.:||||......:.....
  Rat   717 SSAQLHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILSMVPAWHSARLRIFLCLGPREAPGAA 781

  Fly   850 KKDLKTFLYHLRIEADVEVV 869
            :..|:..|..|||.|:|:.|
  Rat   782 EGRLRALLSQLRIRAEVQEV 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	235/865 (27%)
Slc12a9	NP_599232.2	AA_permease_2	36..905	CDD:459263	234/861 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..678		3/32 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	843..864