DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and Slc12a5

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001380604.1	Gene:	Slc12a5 / 171373	RGDID:	620811	Length:	1139	Species:	Rattus norvegicus

Alignment Length:	1131	Identity:	578/1131 - (51%)
Similarity:	775/1131 - (68%)	Gaps:	106/1131 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAAT 81
            |.|.:..::.|..|..    |..:.:      |:.|::::::|.|.:|:.:|.:|||.| :|..:
  Rat    45 PKESSPFINSTDTEKG----REYDGR------NMALFEEEMDTSPMVSSLLSGLANYTN-LPQGS 98

  Fly    82 ---------DPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCC 137
                     :...|....:.||||.:||:|||:|||||||||:|||||||.||.:..|.:|..||
  Rat    99 KEHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICC 163

  Fly   138 CVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLT 202
            ..|||||||||||||||||||||||:|||||||||||||||:.||.|||.|.||||:|.:||:|.
  Rat   164 SCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLA 228

  Fly   203 YMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAV 265
            |:.|..:||  .|.:.:|.||.||.|||||.:|..|..:||:|||:|||||.|.|.||||||:|:
  Rat   229 YLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAI 293

  Fly   266 YVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTK--------EDSFLRDIYCP----DGKCEEYY 318
            |.|:..:........:|:||.|.|.....:.|.|        ..:.|..::|.    :..|:||:
  Rat   294 YAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYF 358

  Fly   319 LANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFI------SYG---KSAIDIENTSGESYNQIMA 374
            ..||||:::||.|.|||:..:|::.|:|.||..:      |.|   .:.:|::      :..:.:
  Rat   359 TRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMD------HPYVFS 417

  Fly   375 DITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDN 439
            |:|:.||||:||:|||||||||||||||||.|||||||.|||.||.|||.||:|||:.|...::.
  Rat   418 DMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 482

  Fly   440 LLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAP 504
            ::||||||:::.|.|||..:|||:.|||:||||.||.|||||||||||||||||:||.|:|||..
  Rat   483 VVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQV 547

  Fly   505 FAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRP 569
            |......||||.|||||..||:.|||:.::|.:||:|||||||||.|||||||||||||||||||
  Rat   548 FGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRP 612

  Fly   570 RFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAAR 634
            ||::|||:||.:|::||:::|.:.|||:||:||.:|.:||||||||||||||||||||::|:|||
  Rat   613 RFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAAR 677

  Fly   635 YSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKIT 699
            |:|||||||||||||||||:|||.:::.:....:.::.|..:||||||||||..||::|......
  Rat   678 YALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNH 742

  Fly   700 NKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-EG 763
            .:|..|:.::|:.|..|||||||.|:::..:.:|:|.:||:.||||::.|||::|||.:||| |.
  Rat   743 PQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKED 807

  Fly   764 RNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPFLLKQHR 827
            ..:|:.||:.||...|.|:||:|.|.::.:|.:..:.. |:||:||||||||:||||||||:.|:
  Rat   808 HQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHK 872

  Fly   828 TWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQ 892
            .||.||:|||||||::||||||||||.||||||||.|:||||||:.|||||||||:||:||||:|
  Rat   873 VWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQ 937

  Fly   893 MLRALGLNKKENSKVVQTIMD------YKETPSDNKMSL-----------------VQTIVDHHY 934
            :|:.:.|.|.|..:.:|:|.|      .::.|::.::.|                 ||.|.|
  Rat   938 ILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETACDNEEKPEEEVQLIHD--- 999

  Fly   935 DATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENA------DTPETTSNKDESTEKADG 993
               ::|.....:.|:..|....:.:.|          ||..      |......||..|...::|
  Rat  1000 ---QSAPSCPSSSPSPGEEPEGEGETD----------PEKVHLTWTKDKSAAQKNKGPSPVSSEG 1051

  Fly   994 --DFKSSVKPD-----EFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEF 1051
              || .|:||:     :.||||||||::||||||.||:||:||::|:|||||  ....:.|||||
  Rat  1052 IKDF-FSMKPEWENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPR--NRNGDENYMEF 1113

  Fly  1052 LEVLTEGLEKVLMVRGGGREVITIYS 1077
            ||||||.|::|::|||||||||||||
  Rat  1114 LEVLTEQLDRVMLVRGGGREVITIYS 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	571/1097 (52%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	206/440 (47%)
Slc12a5	NP_001380604.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		4/20 (20%)
		2a30	44..1139	CDD:273347	576/1129 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..116		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1025		16/97 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1052		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352220
Domainoid	1	1.000	424	1.000	Domainoid score	I595
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I194
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm45216
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910