DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kcc and Slc12a8

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001357928.1	Gene:	Slc12a8 / 171286	MGIID:	2443672	Length:	705	Species:	Mus musculus

Alignment Length:	487	Identity:	136/487 - (27%)
Similarity:	217/487 - (44%)	Gaps:	116/487 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 GTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAG 159
            ||..|||..|:.|||||:||:|..|:||..|.:.|.|:|.....|.::|.:|...:|.:|.:.:|
Mouse    39 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGLLLVSFVVLVALITVLSGIGVAEHGGISSG 103

  Fly   160 GSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNN 224
            |.|.|||..||.:.||.||:|:..|..:|.||||.|..|.:...:.     .||.
Mouse   104 GVYSMISSVLGGQMGGTVGLLYVFGQCVAGAMYITGFAESISDLLG-----LGDI---------- 153

  Fly   225 FRVYGTLLLIFMGL--IVFLGVKFVNKFATVALACVILSIIAVYVGIFDNI---HGNEKLYMCVL 284
            :.|.|..:.:.:.|  |...|||::.:...:.|..:.:|.:...||.|.::   ||       .:
Mouse   154 WAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPEHG-------FI 211

  Fly   285 GKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKG 349
            |                      |.|:                        :...||.|
Mouse   212 G----------------------YSPE------------------------LLQSNILP------ 224

  Fly   350 QFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIG 414
                        |.:.|||:          || :.|:|||:.||:|||.|..|||.|...|:|:|
Mouse   225 ------------EYSPGESF----------FT-VFGVFFPAATGVMAGFNMGGDLRDPADSVPLG 266

  Fly   415 TICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAG 479
            ::.|:..:..:|:..............||..|       |:...::... ::.|:|.::|:|.:.
Mouse   267 SLAAVGVSWFLYIIFAFLLGAVCTREALRSDF-------LIAEKVSLVG-FLFLLGLYISSLASC 323

  Fly   480 LQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGE-PTRALLLTIVICQCGILLGNVDLLAPLLSM 543
            :..|.||||:||.||:|::||.||..|......: |..|:.||.::....:|:|.|::|||::::
Mouse   324 MGGLYGAPRILQCIAQDKVIPALAFLANGKGPNKTPVAAICLTSLVTMAFVLVGQVNVLAPVVTI 388

  Fly   544 FFLMCYGFVN-----LACAVQTLLRTPNWRPR 570
            .|::.|..|:     |:.|...|..:|...||
Mouse   389 NFMLTYIMVDYSYFALSMAHCGLAPSPEPVPR 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	136/487 (28%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515
Slc12a8	NP_001357928.1	2a30	34..>420	CDD:273347	134/485 (28%)
Slc12a8	NP_001357928.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..512
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810