DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and Slc12a6

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_598410.2	Gene:	Slc12a6 / 107723	MGIID:	2135960	Length:	1150	Species:	Mus musculus

Alignment Length:	1116	Identity:	613/1116 - (54%)
Similarity:	801/1116 - (71%)	Gaps:	86/1116 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSNSAKDDSDEMEIIPSEHNGTVHETKNEDSGDIHRAEENQ----------KSSIDPNLYLYDDD 56
            ::::.:|.:::    ||:::.|...::..|.|  |:...|.          ....|.||.|::::
Mouse    81 RTSNPQDVTED----PSQNSITGEHSQLLDDG--HKKARNAYLNNSNYEEGDEYFDKNLALFEEE 139

  Fly    57 LETRPHISTFISSIANYENTIPAA---------TDPDAKPAAPSARMGTLIGVFLPCIQNIFGVI 112
            ::|||.:|:.::.:|||.|....|         |:...|| ..|.:|||.:||:|||:|||||||
Mouse   140 MDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP-TKSPQMGTFMGVYLPCLQNIFGVI 203

  Fly   113 LFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAV 177
            ||:||||||||||.:..|.|||.|||.||||||||||||||||||||||||||||:|||||||||
Mouse   204 LFLRLTWVVGTAGILQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAV 268

  Fly   178 GMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIV 240
            |:.||.|||.||||||:||:||.|.|:.|.|:||  .|..|::.||.||.|||||..|:.|.|:|
Mouse   269 GLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRSDDALKESAAMLNNMRVYGTAFLVLMVLVV 333

  Fly   241 FLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENC--TKE--- 300
            |:||::|||||::.|||||:||:|:|.|...:........:|:||.|.|....|:.|  |||
Mouse   334 FIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHLDICSKTKEVDN 398

  Fly   301 ---DSFLRDIYCPDGK-----CEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFIS--YG 355
               .|.|...:|...:     |:||::.|||..::||.|||||:..:|::.::|.||:.|.  ..
Mouse   399 MTVPSKLWGFFCNSSQFFNATCDEYFVHNNVISIQGIPGLASGIITENLWSNYLPKGEIIEKPSA 463

  Fly   356 KSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAIL 420
            ||:..:.|.:.|   .::||||||||||:||||||||||||||||||||.|||||||||||.|||
Mouse   464 KSSDVLGNLNHE---YVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAIL 525

  Fly   421 TTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTG 485
            |||.||||:|:.|...::.::||||||.::.|.|||..::||:.|||:||||.||.|||||||||
Mouse   526 TTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTG 590

  Fly   486 APRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYG 550
            |||||||||:|.|||||..|..|...||||.|||||..|.:.|||:.::||:||:|||||||||.
Mouse   591 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYL 655

  Fly   551 FVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYR 615
            |||||||:|||||||||||||::|||:||.:|:::|:::|.::|||:|::||.:|.:|||||||:
Mouse   656 FVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ 720

  Fly   616 GAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKA 680
            ||||||||||||::|:|||::|||||||||||||||||:|||.||:::|..|:.::.:||:||||
Mouse   721 GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 785

  Fly   681 GKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGG 745
            ||||||..|||.|:..:....|:.|:.|::..|..|||||||.::||.::.||:|.:||:.||||
Mouse   786 GKGLTIVGSVIVGNFLENYGDALAAEQTIKHLMEAEKVKGFCQLVVAAKLKEGISHLIQSCGLGG 850

  Fly   746 MKPNTVIIGWPYSWRQ-EGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWW 808
            ||.|||::|||..||| |...:|||||.|||...|.|:||:|.|.::|:|.:..:.. ||||:||
Mouse   851 MKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNVSFFPSNVEQFSEGNIDVWW 915

  Fly   809 IVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNN 873
            ||||||:|||||||||||:.||.|.:|||||||:|||||||||||.||||||||||:||||||::
Mouse   916 IVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHD 980

  Fly   874 SDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATK 938
            |||||||||||||||||:||||.:.|:|.|..:..|.:.|      .|.|..:.:|.....:.|:
Mouse   981 SDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD------RNSMLRLTSIGSDEDEETE 1039

  Fly   939 TASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKS--SVKP 1001
                      |.:|..|.....|                 :..:::.:..:..:| |:.  :::|
Mouse  1040 ----------TYQEKVHMTWTKD-----------------KYMASRGQKVKSMEG-FQDLLNMRP 1076

  Fly  1002 DEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVR 1066
            |:.||||||||:|||||||.||.:|:||::|:|||||  ..|.:.||||||||||||||:||:||
Mouse  1077 DQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPR--NPEGDENYMEFLEVLTEGLERVLLVR 1139

  Fly  1067 GGGREVITIYS 1077
            |||.|||||||
Mouse  1140 GGGSEVITIYS 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	602/1057 (57%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	217/406 (53%)
Slc12a6	NP_598410.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108		5/30 (17%)
		2a30	109..1150	CDD:273347	605/1080 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..181		4/20 (20%)
		SLC5-6-like_sbd	209..>360	CDD:294310	105/150 (70%)
		SLC12	774..1150	CDD:281515	217/411 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848608
Domainoid	1	1.000	426	1.000	Domainoid score	I607
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1163	1.000	Inparanoid score	I205
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm43147
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3041
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800