Protein Alignment kcc and Slc12a6

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_598410.2
• Gene: Slc12a6 / 107723
• MGIID: 2135960
• Length: 1150
• Species: Mus musculus
• Alignment Length: 1116
• Identity: 613/1116 - (54%)
• Similarity: 801/1116 - (71%)
• Gaps: 86/1116 - (7%)

  Fly     2 QSNSAKDDSDEMEIIPSEHNGTVHETKNEDSGDIHRAEENQ----------KSSIDPNLYLYDDD 56
            ::::.:|.:::    ||:::.|...::..|.|  |:...|.          ....|.||.|::::
Mouse    81 RTSNPQDVTED----PSQNSITGEHSQLLDDG--HKKARNAYLNNSNYEEGDEYFDKNLALFEEE 139

  Fly    57 LETRPHISTFISSIANYENTIPAA---------TDPDAKPAAPSARMGTLIGVFLPCIQNIFGVI 112
            ::|||.:|:.::.:|||.|....|         |:...|| ..|.:|||.:||:|||:|||||||
Mouse   140 MDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP-TKSPQMGTFMGVYLPCLQNIFGVI 203

  Fly   113 LFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAV 177
            ||:||||||||||.:..|.|||.|||.||||||||||||||||||||||||||||:|||||||||
Mouse   204 LFLRLTWVVGTAGILQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAV 268

  Fly   178 GMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIV 240
            |:.||.|||.||||||:||:||.|.|:.|.|:||  .|..|::.||.||.|||||..|:.|.|:|
Mouse   269 GLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRSDDALKESAAMLNNMRVYGTAFLVLMVLVV 333

  Fly   241 FLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENC--TKE--- 300
            |:||::|||||::.|||||:||:|:|.|...:........:|:||.|.|....|:.|  |||
Mouse   334 FIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHLDICSKTKEVDN 398

  Fly   301 ---DSFLRDIYCPDGK-----CEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFIS--YG 355
               .|.|...:|...:     |:||::.|||..::||.|||||:..:|::.::|.||:.|.  ..
Mouse   399 MTVPSKLWGFFCNSSQFFNATCDEYFVHNNVISIQGIPGLASGIITENLWSNYLPKGEIIEKPSA 463

  Fly   356 KSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAIL 420
            ||:..:.|.:.|   .::||||||||||:||||||||||||||||||||.|||||||||||.|||
Mouse   464 KSSDVLGNLNHE---YVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAIL 525

  Fly   421 TTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTG 485
            |||.||||:|:.|...::.::||||||.::.|.|||..::||:.|||:||||.||.|||||||||
Mouse   526 TTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTG 590

  Fly   486 APRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYG 550
            |||||||||:|.|||||..|..|...||||.|||||..|.:.|||:.::||:||:|||||||||.
Mouse   591 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYL 655

  Fly   551 FVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYR 615
            |||||||:|||||||||||||::|||:||.:|:::|:::|.::|||:|::||.:|.:|||||||:
Mouse   656 FVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ 720

  Fly   616 GAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKA 680
            ||||||||||||::|:|||::|||||||||||||||||:|||.||:::|..|:.::.:||:||||
Mouse   721 GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKA 785

  Fly   681 GKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGG 745
            ||||||..|||.|:..:....|:.|:.|::..|..|||||||.::||.::.||:|.:||:.||||
Mouse   786 GKGLTIVGSVIVGNFLENYGDALAAEQTIKHLMEAEKVKGFCQLVVAAKLKEGISHLIQSCGLGG 850

  Fly   746 MKPNTVIIGWPYSWRQ-EGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWW 808
            ||.|||::|||..||| |...:|||||.|||...|.|:||:|.|.::|:|.:..:.. ||||:||
Mouse   851 MKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNVSFFPSNVEQFSEGNIDVWW 915

  Fly   809 IVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNN 873
            ||||||:|||||||||||:.||.|.:|||||||:|||||||||||.||||||||||:||||||::
Mouse   916 IVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHD 980

  Fly   874 SDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATK 938
            |||||||||||||||||:||||.:.|:|.|..:..|.:.|      .|.|..:.:|.....:.|:
Mouse   981 SDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD------RNSMLRLTSIGSDEDEETE 1039

  Fly   939 TASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKS--SVKP 1001
                      |.:|..|.....|                 :..:::.:..:..:| |:.  :::|
Mouse  1040 ----------TYQEKVHMTWTKD-----------------KYMASRGQKVKSMEG-FQDLLNMRP 1076

  Fly  1002 DEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVR 1066
            |:.||||||||:|||||||.||.:|:||::|:|||||  ..|.:.||||||||||||||:||:||
Mouse  1077 DQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPR--NPEGDENYMEFLEVLTEGLERVLLVR 1139

  Fly  1067 GGGREVITIYS 1077
            |||.|||||||
Mouse  1140 GGGSEVITIYS 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	602/1057 (57%)
Slc12a6	NP_598410.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108		5/30 (17%)
		2a30	109..1150	CDD:273347	605/1080 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..181		4/20 (20%)
		Scissor helix. /evidence=ECO:0000250|UniProtKB:Q9UHW9	682..691		3/8 (38%)