Protein Alignment kcc and slc12a3

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_002937217.2
• Gene: slc12a3 / 100494755
• XenbaseID: XB-GENE-866805
• Length: 1030
• Species: Xenopus tropicalis
• Alignment Length: 1160
• Identity: 295/1160 - (25%)
• Similarity: 476/1160 - (41%)
• Gaps: 313/1160 - (26%)

  Fly    25 HETKNEDSGDIHRAEENQKSSIDPNLYLYDDDL------ETRPHISTFISSIANYENTIP----A 79
            |....|.||.|.:        :.|.|    :||      ::..|:..     .:|:||:.    .
 Frog    74 HYANTEISGQIKK--------VRPTL----EDLHSILKQDSSHHLDP-----PDYDNTVEPPDGE 121

  Fly    80 ATDPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTA 144
            |.:.:.|||....|.|.:.||.:.|:.||:||||::||.|:...||....:||:.....||.:|.
 Frog   122 AENTEQKPAGEPVRFGWIKGVMIRCMLNIWGVILYLRLPWITAQAGIALTWLIIFMSVTVTSITG 186

  Fly   145 ISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWAS 209
            :|:|||:|||.|.:||:||:||||||||.||::|::|.....:|.||:.||..|.|
 Frog   187 LSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVAVAMHTVGFAETV--------- 242

  Fly   210 IFGDFTKDADAM----YNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIF 270
              .|..:|.|:.    .|:.|:.|.:.:|.:..|...|:::..|...:....:::|.....||..
 Frog   243 --RDLLRDYDSTIVDPINDIRIIGIITVIVLLGISLAGMEWEAKAQILFFIVIMISFANYLVGTV 305

  Fly   271 DNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASG 335
                                 ||                          |....:.||.....:.
 Frog   306 ---------------------IP--------------------------ATEEKQAKGFFSYRAD 323

  Fly   336 VFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNR 400
            :|.:|..|.:  :||                          ..||..:..|||||.|||:||:|.
 Frog   324 IFAENFVPKW--RGQ--------------------------DGSFFGMFSIFFPSATGILAGANI 360

  Fly   401 SGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQ-----SIGGKLVV---A 457
            ||||.|...:||.||:.:|..|:..||    ..:.|:.:.::||..|.     :.||...|   .
 Frog   361 SGDLKDPTVAIPKGTLMSIFWTTVSYL----VISATIGSCVVRDASGSLNDTITDGGLNCVGLAC 421

  Fly   458 NIAWP---------------NQW-----------VILIGSFLSTLGAGLQSLTGAPRLLQAIARD 496
            ...|.               ||:           ::..|.|.:||.:.|..|..||::.|.:.:|
 Frog   422 GYGWNFTDCATKQNCKYGLINQYQSMSMVSGFAPLVTAGIFGATLSSALACLVSAPKVFQCLCKD 486

  Fly   497 EIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQT 560
            .:.|.:..|.|. .|..||.|..|||.:|....||:|.::.:||::|.|||..|..:|.:|...:
 Frog   487 NLYPLIGFFGKGYGKNNEPIRGYLLTFLIASAFILIGELNTIAPIISNFFLCSYALINFSCFHAS 551

  Fly   561 LLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGI 625
            :..:|.|||.||:|....||.|....:.:|.:.:|..||||:|:.|.:..|:.|:..|..||..:
 Frog   552 ITNSPGWRPSFKYYSKWASLFGAVASVVIMFLLAWESALIAIGIVIFLLGYVLYKKPEANWGSSV 616

  Fly   626 RGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYR-KIFSFATQLKAGKGLTICVS 689
            :..:...|....:.|.:...|.||:|||.|||:.     .|.:| .:..|.......:.|.||.:
 Frog   617 QAGSYNMALSYCVGLNQVEEHIKNFRPQCLVLTG-----PPNFRPALVDFVGTFTKKQSLMICGN 676

  Fly   690 VIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIG 754
            ||.|.. |...:.:..:..: |::...|:|.|...|:|..:..|...:||..|||.|:||.:::|
 Frog   677 VIIGPR-KQKLQEISPEGHI-KWLNKRKIKAFYTGLIADDLRSGTQMLIQAAGLGHMRPNVLVMG 739

  Fly   755 WPYSWRQEGRNSWKTFIQTVRTVA--ACHMALM-VPKGINF-----------YPESNH---KIGG 802
            :..:|......|.:.::..:....  .|.:.|: :.:|||.           |.::..   |.||
 Frog   740 FKKNWSTSHPRSTENYVGILHDALDFKCGLCLLRMKEGINISRVMQAHINPVYEQTEEPKLKDGG 804

  Fly   803 ----------------------------------NIDIWWIVHDGGLLMLLPFLLKQHRTWRNCK 833
                                              .|||:|:..||||.:|:|:||.:.:.|:..|
 Frog   805 ENGASCSAQSTLDPEAVTVEQQASTIFQIKQDKKTIDIYWLFDDGGLTLLIPYLLSRKKRWQKAK 869

  Fly   834 LRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALG 898
            :|:|...||.    :|.::.|..:                          :|:.:.|      :|
 Frog   870 IRVFVGGQIN----RMDEECKAMI--------------------------SLLSKFR------IG 898

  Fly   899 LNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQNDEK 963
            .::      |..:.|..:.|....:.                   ||.| .|.....:|...||.
 Frog   899 FHE------VHVLPDINQKPRPEHIK-------------------RFED-LIAPYMLNDGFKDEL 937

  Fly   964 R-NSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQ 1027
            . |.:..|.|......|...|:.:|..:                      |:||||:::.|:||.
 Frog   938 TVNEMRRDCPWKISDEEIKKNRAKSLRQ----------------------IRLNEVLLDYSRDAG 980

  Fly  1028 LVIMNLPGPPREVRAERERN-----YMEFLEVLTEGLE-KVLMVRGGGREVITIY 1076
            |:::.:|       ..|:..     ||.:||.|::.|. .||:.||..:.|:|:|
 Frog   981 LIVITMP-------IARKGKCPSTLYMAWLETLSQDLRPPVLLTRGNQQNVLTMY 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	289/1136 (25%)
slc12a3	XP_002937217.2	2a30	64..1029	CDD:273347	295/1160 (25%)