Protein Alignment kcc and slc12a4

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_002942716.1
• Gene: slc12a4 / 100493471
• XenbaseID: XB-GENE-1014107
• Length: 1090
• Species: Xenopus tropicalis
• Alignment Length: 1104
• Identity: 600/1104 - (54%)
• Similarity: 794/1104 - (71%)
• Gaps: 76/1104 - (6%)

  Fly     4 NSAKDDSDEMEIIPSEHNGTVHETKNEDSGDIHRAEENQKSSI-DPNLYLYDDDLETRPHISTFI 67
            :|::|..|.   :.|:.:|..    .|:|..:..:|.|:.:.. |.||.|::::|:.||.:|:|:
 Frog    33 HSSRDPYDS---VSSDGHGNY----KENSPFLTGSEANKGNQFYDKNLALFEEELDIRPKVSSFL 90

  Fly    68 SSIANYENTIPAATDPDAKPAA-----PSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAV 127
            |.:.||.|....|.:.:....|     .|..|||::||:|||:|||.|||||:||||:|||.|.:
 Frog    91 SRLVNYTNLTQGAKEHEEAEEARRKVNKSPCMGTVMGVYLPCMQNILGVILFLRLTWIVGTGGVL 155

  Fly   128 CGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMY 192
            ...||.|.|||.|:|||||||||||||||||||||||||||||||||||||:.||.|||.|.|||
 Frog   156 QTLLITLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAGAMY 220

  Fly   193 IVGAVEIVLTYMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVAL 255
            |:||:||:|.|:.|.|:||  .:..:|:.|..||.|||||:.|..|.:|||:|||:|||||::.|
 Frog   221 ILGAIEILLMYIVPEAAIFHSPNTHEDSSAKLNNMRVYGTVFLTLMAIIVFVGVKYVNKFASLFL 285

  Fly   256 ACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLL---------KDIPLENCTKEDSFLRDIYC-- 309
            ||||:||:::|.|...:|.......:|:||.|.|         |.|.|:|.||..: |.:.:|
 Frog   286 ACVIISILSIYAGSIKSIFDPPVFPICMLGNRTLSRDRFEICAKTIILDNVTKPTT-LWEQFCGS 349

  Fly   310 ---PDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGK-SAIDIENTSGESYN 370
               ....|::|:|.||||::.||.|.|||:..||::.::|:||:.:...: |::|...:....:.
 Frog   350 SNFSTSSCDQYFLKNNVTEIAGIPGAASGILKDNLWSNYLQKGEILEKSQLSSVDELGSKSNLHL 414

  Fly   371 QIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAG 435
            .::.||:.:||:|:||||||||||||||||||||.|||||||:|||.||:|||.:|.|:|:.|..
 Frog   415 YVLTDISATFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSFIYFSTVVLFGA 479

  Fly   436 TVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIP 500
            .::.::||||:|.::...|||..::||:.|||:||||.||.||||||||||||||||||.|.|||
 Frog   480 CIEGVVLRDKYGDAVNKNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIANDNIIP 544

  Fly   501 FLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTP 565
            ||..|.:....||||.|||||..|.:.|||:.::|::||:|||||||||.|||||||||||||||
 Frog   545 FLRVFGQGKVNGEPTWALLLTAFIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTP 609

  Fly   566 NWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMAL 630
            |||||||:|||:||..|:::|:::|.:.|||:|||||.:|.:|||||||:||||||||||||::|
 Frog   610 NWRPRFKYYHWALSFFGMSICLALMFVCSWYYALIAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 674

  Fly   631 TAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDH 695
            :||||:|||||||||||||||||:|||.||:::|..||.::.:|::||||||||||..:.::|:.
 Frog   675 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFSSQLKAGKGLTIIGTTLQGNF 739

  Fly   696 TKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWR 760
            .:...:...|:.|::..|..||||||..|:|:.::.:|:|.:||:.||||||.|||::||||.||
 Frog   740 LESYGEVQAAEQTIKNMMEIEKVKGFSQVVVSSEVCDGISHLIQSCGLGGMKHNTVLLGWPYGWR 804

  Fly   761 Q-EGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHK--IGGNIDIWWIVHDGGLLMLLPFL 822
            | |...||||||..||...|..:||||||.::||| |||:  :.||||:||||||||:|||||||
 Frog   805 QSEDPRSWKTFIDAVRCTTAARLALMVPKNVSFYP-SNHERYLEGNIDVWWIVHDGGMLMLLPFL 868

  Fly   823 LKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMM 887
            ||||:.|:.||:|||||||::||||||||||.|||||||:||:||||||:|||||||||||||||
 Frog   869 LKQHKVWKKCKMRIFTVAQLDDNSIQMKKDLATFLYHLRLEAEVEVVEMHNSDISAYTYERTLMM 933

  Fly   888 EQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEE 952
            |||:||||.:.|.|.|..:..|.:.|        :.|::.  |:.:|      |.....:|.:|.
 Frog   934 EQRSQMLRQMRLTKTERDREAQLVKD--------RNSIIP--VESYY------SDEEDEEPELEL 982

  Fly   953 TQHHDSQNDEKRNSIDLDGPENADTPETTSNKDEST----EKADGDFKSSVKPDEFNVRRMHTAI 1013
            .:.|.:...:|.|:             ...|::..|    |.||      :|||:.||||||||:
 Frog   983 AKIHMTWTKDKYNA-------------QWKNRNNETMHFRELAD------IKPDQSNVRRMHTAV 1028

  Fly  1014 KLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            |||||||.:|.||:||::|:||||:  ..:.:.||||||||||||||:||:|||||||||||||
 Frog  1029 KLNEVIVTRSHDAKLVLLNMPGPPK--NTDGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	588/1056 (56%)
		SLC12	674..1077	CDD:281515	219/409 (54%)
slc12a4	XP_002942716.1	2a30	49..1090	CDD:273347	593/1083 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	429	1.000	Domainoid score	I592
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21056
Inparanoid	1	1.050	1154	1.000	Inparanoid score	I208
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm48284
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080