Protein Alignment kcc and slc12a1

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_002936613.2
• Gene: slc12a1 / 100490198
• XenbaseID: XB-GENE-479925
• Length: 1086
• Species: Xenopus tropicalis
• Alignment Length: 1235
• Identity: 313/1235 - (25%)
• Similarity: 498/1235 - (40%)
• Gaps: 362/1235 - (29%)

  Fly     9 DSDEMEIIPSE--------HNGTVHETKN-----EDSGDIHRAEENQKSSID--PNLYLYDDDLE 58
            |.:.|...|..        |||...:|:.     :..|..:..:....:::|  |.:..|.:...
 Frog    48 DDNRMSYRPGNREIFNNVLHNGDTIKTEGSFHPYDTHGHAYYMKTFGHNTVDAVPKIDYYRNTGS 112

  Fly    59 ------TRPHISTFISSIANYENTIP-AATDPDAKPAAPSA-----------RMGTLIGVFLPCI 105
                  .||.::.....::.....:| :.|:.:..|....|           :.|.:.||.:.|:
 Frog   113 ISGVKICRPSLADIHEQLSKNVVEVPGSVTNGEGIPGDEEANKEEGEKGGFVKFGWIKGVLVRCM 177

  Fly   106 QNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLG 170
            .||:||:|||||:|:||.||...|.:|:.....||.||.:|||||.|||||..||:|::||||||
 Frog   178 LNIWGVMLFIRLSWIVGQAGIGLGVVIICLSVVVTSLTGVSMSAICTNGVVRGGGAYYLISRSLG 242

  Fly   171 PEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAM----YNNFRVYGTL 231
            |||||::|::|.....:|.|||:||..|.|:           :..||.:.:    .|:.|:.||:
 Frog   243 PEFGGSIGLIFAFANAVAVAMYVVGFSETVV-----------EILKDTNTIMVDEVNDIRIIGTI 296

  Fly   232 LLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLEN 296
            .:|.:..|...|:::..|...|.|..::::|:..::|..                     ||
 Frog   297 TVILLLGISVAGMEWEAKAQVVLLVILLIAIVNFFIGTV---------------------IP--- 337

  Fly   297 CTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDI 361
            .|||                       .:.:|.....:.:|.:|..|.|
 Frog   338 TTKE-----------------------KRAQGFFNYQATIFAENFGPDF---------------- 363

  Fly   362 ENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVY 426
              .:||.:..:.|           ||||:.|||:||:|.||||.|.|.:||.||:.|||.|:..|
 Frog   364 --RNGEGFFSVFA-----------IFFPAATGILAGANISGDLKDPQGAIPKGTMWAILITTIAY 415

  Fly   427 LSSVMFFAGTVDNLLLRDKFGQ-----------------SIGGKLVV-----ANIAWPNQW---- 465
            |...:..|.:|    :||..|.                 .:|....:     .|....|.:
 Frog   416 LGVAICAAASV----VRDATGNLNDTITSAFKCNGSAACGLGYDFSICETQTCNYGLMNNFQVMS 476

  Fly   466 -------VILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTI 522
                   :|:.|.|.:||.:.|.||..||::.||:.:|.|...|..|||. .|..||.|..:||.
 Frog   477 MVSGFGPLIIAGIFSATLSSALASLVSAPKVFQALCKDNIYKGLHFFAKGHGKNNEPIRGYVLTF 541

  Fly   523 VICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCI 587
            ||....||:..::::||::|.|||..|..:|.:|...:..::|.|||.||:|:..:||.|..||.
 Frog   542 VIALAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRPAFKYYNMWVSLFGAMLCC 606

  Fly   588 SVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRP 652
            .||.:.:|:.|||...:.:.:|.|:.|:..:..||...:.:....|..|.|.|.....|.||:||
 Frog   607 GVMFVINWWAALITYAIELFLYIYVTYKKPDVNWGSSTQALQFKNALDSALGLNCIEDHVKNFRP 671

  Fly   653 QILVLSKLNDNLLPKYR-KIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDE 716
            |.:||:.     :|..| .:...........||.||..|..|...:...:........:.::|:.
 Frog   672 QCIVLTG-----VPMTRPALLDITHSFTKNSGLCICCEVFSGPRKQAVKEMNSGMIKKQTWLTNN 731

  Fly   717 KVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACH 781
            |.|.|...:.|....:|:.:::|..|||.:||||:::|:...|||...      :.....|...|
 Frog   732 KRKAFYAAVAADNFRDGVRTLLQASGLGRLKPNTLVMGFKKDWRQASP------VDLANYVGILH 790

  Fly   782 MALMVPKGI-------------------------------------NFYPESNH----------- 798
            .|.....|:                                     |.:.|.||
 Frog   791 DAFDFEHGVVIVRISQGFDISQVLQVKEEFDRLEQERLALEQTIKENEFKEGNHGLRSFFNKTAK 855

  Fly   799 ------------------KIG-------------------GNIDIWWIVHDGGLLMLLPFLLKQH 826
                              .:|                   |.||:||:..||||.:|:|.:|...
 Frog   856 LNINRHSSTKDVSTPPPMHVGEYNQRLVEASEQFKKNQGKGMIDVWWLFDDGGLTLLIPHILTLR 920

  Fly   827 RTWRNCKLRIF---TVAQIEDNSIQMKKDLKTFLYHLRIE-ADVEVVEMNNSDISAYTYERTLMM 887
            :.|::||||||   .|.::||..:.|...|..|    ||: ||:.:|    .||
 Frog   921 KKWKDCKLRIFIGGKVNRLEDEKLMMASLLSKF----RIKFADIYIV----GDI----------- 966

  Fly   888 EQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDH---HYDAT--KTASKVRFAD 947
                            |:|           ||.......:.:::.   |.::|  .||.|:|..:
 Frog   967 ----------------NTK-----------PSKESWKFFEEMIEPYCLHENSTDVSTAEKIRREN 1004

  Fly   948 PTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTA 1012
            |                            ...|.|..:...||:                  :..
 Frog  1005 P----------------------------WKITDSELEMFKEKS------------------YRQ 1023

  Fly  1013 IKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            ::|||::.|.|:.|.|::::||...:  .:..:..||.::|:|::.|..||:|||..:.|:|.||
 Frog  1024 VRLNELLQEHSRSANLIVLSLPVARK--GSVSDHLYMAWVEILSKNLPPVLLVRGNHKNVLTFYS 1086

  Fly  1078  1077
             Frog  1087  1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	301/1178 (26%)
slc12a1	XP_002936613.2	2a30	96..1086	CDD:273347	303/1185 (26%)