Protein Alignment kcc and slc12a1

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_021323409.1
• Gene: slc12a1 / 100329975
• ZFINID: ZDB-GENE-080130-3
• Length: 1037
• Species: Danio rerio
• Alignment Length: 1229
• Identity: 319/1229 - (25%)
• Similarity: 506/1229 - (41%)
• Gaps: 355/1229 - (28%)

  Fly     5 SAKDDSDEME--------------------IIPSEHNGTVHETKNED--------SGDIHRAEEN 41
            ::|||..:.|                    ::.:..:.|:....|.|        ||  |||
Zfish     8 TSKDDPPQYEETSFCTNGFGNGERRAIRSSVVSAFGHDTLDRVPNPDFYRNAASISG--HRA--- 67

  Fly    42 QKSSIDPNLY-LYD-----------DDLETRPHISTFISSIANYENTIPAATDPDAKPAAPSARM 94
                :.|:|: |:|           ..:|....:.:  |::.:.|:..|.    :.|......:.
Zfish    68 ----VRPSLHELHDVFQKNGGLNLPSPVEDSEGVDS--STLGDVESVTPL----EEKDTGGVVKF 122

  Fly    95 GTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAG 159
            |.:.||.:.|:.||:||:|||||:||.|.||...|.::||....||.:|.:|||||.|||||..|
Zfish   123 GWIKGVLVRCMLNIWGVMLFIRLSWVFGQAGIGLGIVVVLLSMVVTSVTCLSMSAICTNGVVRGG 187

  Fly   160 GSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMY-- 222
            |:|::|||||||||||::|::|.....:|.|||:||..|.|:           :..||::|:.
Zfish   188 GAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV-----------ELLKDSNALIVD 241

  Fly   223 --NNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIA-VYVGIFDNIHGNEKLYMCVL 284
              |:.|:.|.:.::.:..|...|:::..| |.|||..::|..|| |:||..
Zfish   242 PTNDIRIIGCITVVLLMGITVAGMEWEAK-AQVALLVILLVAIANVFVGTV-------------- 291

  Fly   285 GKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKG 349
                   ||    :.:|.                      :.||.......:..:|..|.|.:
Zfish   292 -------IP----STQDK----------------------RSKGFFNYHESIAKENFIPDFRD-- 321

  Fly   350 QFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIG 414
                            ||::..:.|           ||||:.|||:||:|.||||.|.|.::|.|
Zfish   322 ----------------GETFFSVFA-----------IFFPAATGILAGANISGDLRDPQGALPKG 359

  Fly   415 TICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQ-----SIGG-----------------KLVVA 457
            |:.||..|...||...:..:.||    :||..|.     ..|.                 :....
Zfish   360 TLLAIFITGVTYLGIALVVSVTV----VRDATGNRNDTIQAGASCNFSSACDFGYDFSICQTTKC 420

  Fly   458 NIAWPNQW-----------VILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SK 510
            |....|.:           :|..|:|.:||.:.|.||..||::.||:.:|.|...|..|||. .|
Zfish   421 NYGLMNNFQVMTLVSGFGPLITAGTFSATLSSALASLVSAPKVFQALCKDNIYKALKFFAKGHGK 485

  Fly   511 RGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYH 575
            ..||.|..:||.:|....||:..::.:||::|.|||..|..:|.:|...:..::|.|||.:|:|:
Zfish   486 NNEPIRGYVLTFIIAVAFILIAQLNTIAPIISNFFLASYALINYSCFHASYAKSPGWRPAYKYYN 550

  Fly   576 WSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRL 640
            ..|||.|..||.:||.:.:|:.||:..|:...:|.|:..:..:..||...:.:....|..:.|.|
Zfish   551 MWLSLFGAVLCCAVMFVINWWAALLTYGIEFFLYIYVTVKKPDVNWGSSTQAVTFINAVNNALIL 615

  Fly   641 EEGPPHTKNWRPQILVLSKLNDNLLPKYR-KIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVD 704
            .....|.||:||:.|||:.     .|:.| .:...:.......||.:...|..|...|.....::
Zfish   616 SGVDDHIKNFRPKCLVLTG-----SPRSRPALLDLSHSFTKNYGLCLTCEVFVGSRDKNLQDMIE 675

  Fly   705 AKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWR----QEGRN 765
            .....:.::..:|.|.|...:.:..:.:|..:::|..|||.||||||::|:...||    |:.:|
Zfish   676 GDVQNQLWLNKQKHKAFYTPIASDTLRDGAQALMQASGLGRMKPNTVMLGFKRDWRTSKPQDVQN 740

  Fly   766 ----SWKTFIQTVRTV---------------AACHMALMV----------------PKGINFY-- 793
                ...||...:.||               |...|..|:                |:|  |:
Zfish   741 YVGILHDTFDFELGTVIMRVSQGMDISHILKAEEEMERMILEQQALEMEENDFQPGPRG--FFNR 803

  Fly   794 --------PESNHKIG---------------------------GNIDIWWIVHDGGLLMLLPFLL 823
                    |.|...:|                           ||||:||:..||||.:|||.:|
Zfish   804 AKKTPKKEPTSKVSLGVPQASDLAKLNQRLVEASGQFKQQQGKGNIDVWWLFDDGGLTLLLPHIL 868

  Fly   824 KQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMME 888
            ...:.||.|:||||...|.|                 ||:.|.|.:::
Zfish   869 TTRKKWRECRLRIFIAGQPE-----------------RIQQDKEEMQL----------------- 899

  Fly   889 QRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEET 953
                :|:...: |.|:.||   |.|....||.....|.:.:                    ||..
Zfish   900 ----LLKKFRI-KCEDIKV---ISDLNIRPSAENWKLFEDM--------------------IEPF 936

  Fly   954 QHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEV 1018
            :.|:...|..:..              ...|::..:..|.:.      |.|..:.| ..::|||:
Zfish   937 RLHEGSKDSSQTE--------------ALRKEQPWKITDAEL------DAFEQKTM-LQVRLNEL 980

  Fly  1019 IVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            :.|.|:.|:|::::||...:  .:..:..||.:||.||:.|...|::||..:.|:||||
Zfish   981 LQESSRAAKLIVVSLPIARK--GSVSDHLYMAWLEALTKNLPPTLLIRGNHKSVLTIYS 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	304/1155 (26%)
slc12a1	XP_021323409.1	2a30	45..1037	CDD:273347	313/1190 (26%)