DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nap1 and Nap1l1

DIOPT Version :9

Sequence 1:	NP_001246485.1	Gene:	Nap1 / 37798	FlyBaseID:	FBgn0015268	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_446013.2	Gene:	Nap1l1 / 89825	RGDID:	71094	Length:	391	Species:	Rattus norvegicus

Alignment Length:	390	Identity:	179/390 - (45%)
Similarity:	246/390 - (63%)	Gaps:	42/390 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DPESCNEIEDEKSGSDCQSMPAYMNSVMRRQYLQQM------------------------VKMLP 50
            |.|...|:|:|::|.:        ..:..||...||                        ::.||
  Rat    15 DLEDVEEVEEEETGEE--------TKIKARQLTVQMMQNPQILAALQERLDGLVDTPTGYIESLP 71

  Fly    51 APVQNRIVFLKNLQLQHLNIEAQFFEDVYKLEQKYQVQYQPLFDKRREIIEGKVDPAEEKPQWKE 115
            ..|:.|:..|||||::...|||:|:|:|:.||:||.|.||||||||.|||....:|.||:.:||.
  Rat    72 KVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKP 136

  Fly   116 PESSTDNEADAEHFREALSSLKSIPKDAKGIPGFWLTVFRNTAIMSEMVQPHDEPAIRKLIDISI 180
            .|....:|...|..:..........:|.||||.||||||:|..::|:|||.||||.::.|.||.:
  Rat   137 DEEDEVSEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKV 201

  Fly   181 KY-DNGH--SYTLEFHFDKNEYFSNSVLTKQYVLKSTVDPNDPFAFEGPEIYKCTGCTINWEKKM 242
            |: |.|.  |:.|||||:.||||:|.||||.|.::|..|.:|||:|:||||..||||.|:|:|..
  Rat   202 KFSDAGQPMSFILEFHFEPNEYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGK 266

  Fly   243 NLTVKTIRKKQKHKERGAVRTIVKQVPTDSFFNFFSPPEVPSDQEEVDDDSQQILATDFEIGHFL 307
            |:|:|||:||||||.||.|||:.|.|..|||||||:||||| :..::|||::.|||.||||||||
  Rat   267 NVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNFFAPPEVP-ENGDLDDDAEAILAADFEIGHFL 330

  Fly   308 RARIIPKAVLYYTGDIVDDEDDEDEEEYDENEE--DEYDDDDAPPPKGPKSAGIKKQSPNDCPNQ 370
            |.||||::|||:||:.::|:||:.:||.:|.:|  :|..|::..|...||    |.|:|.:|..|
  Rat   331 RERIIPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPK----KDQNPAECKQQ 391

Fly 371 370
Rat 392 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nap1	NP_001246485.1	NAP	55..321	CDD:279323	147/268 (55%)
Nap1l1	NP_446013.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		6/24 (25%)
		NAP	76..343	CDD:395763	147/267 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..163		5/29 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	273..279		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..391		16/48 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1462
eggNOG	1	0.900	-	-		E1_KOG1507
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129218
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2380
OMA	1	1.010	-	-		QHG53841
OrthoDB	1	1.010	-	-		D1216172at2759
OrthoFinder	1	1.000	-	-		FOG0000988
OrthoInspector	1	1.000	-	-		otm45656
orthoMCL	1	0.900	-	-		OOG6_100833
Panther	1	1.100	-	-	LDO	PTHR11875
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X426
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840