DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nap1 and NAP1

DIOPT Version :9

Sequence 1:	NP_001246485.1	Gene:	Nap1 / 37798	FlyBaseID:	FBgn0015268	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_012974.1	Gene:	NAP1 / 853922	SGDID:	S000001756	Length:	417	Species:	Saccharomyces cerevisiae

Alignment Length:	384	Identity:	120/384 - (31%)
Similarity:	199/384 - (51%)	Gaps:	50/384 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EDEKSGSDCQ-----SMPAYMNSVMRRQYLQQMVKM-------LPAPVQNRIVFLKNLQLQHLNI 70
            :|:|.|:..:     :.|..:.|:..|  |..:|..       ||..|:.:::.||.||.:...:
Yeast    47 QDDKIGTINEEDILANQPLLLQSIQDR--LGSLVGQDSGYVGGLPKNVKEKLLSLKTLQSELFEV 109

  Fly    71 EAQFFEDVYKLEQKYQVQYQPLFDKRREIIEGKVDPAEEK--------PQWKEPESSTDNEADAE 127
            |.:|..::::||.|:..:|:|::::|..||.|:..|..|:        ....|.|...|.|..|:
Yeast   110 EKEFQVEMFELENKFLQKYKPIWEQRSRIISGQEQPKPEQIAKGQEIVESLNETELLVDEEEKAQ 174

  Fly   128 HFREALSSLKSIPKDAKGIPGFWLTVFRNTAIMSEMVQPHDEPAIRKLIDISIKY--DNGHSYTL 190
            :..|        .:..||||.||||...|..|:.:.:...|...:..|.||.::|  |....:.|
Yeast   175 NDSE--------EEQVKGIPSFWLTALENLPIVCDTITDRDAEVLEYLQDIGLEYLTDGRPGFKL 231

  Fly   191 EFHFDK--NEYFSNSVLTKQYVLKSTVDPNDPFAFEGPEIYKCTGCTINW-EKKMNLTVKTIRKK 252
            .|.||.  |.:|:|.:|.|.|..:..:..:..|.::..|     ||.|:| :...|:||....:|
Yeast   232 LFRFDSSANPFFTNDILCKTYFYQKELGYSGDFIYDHAE-----GCEISWKDNAHNVTVDLEMRK 291

  Fly   253 QKHKERGAVRTIVKQVPTDSFFNFFSPPEVPSD--QEEVDDDSQQILATDFEIGHFLRARIIPKA 315
            |::|....||||.|..|.:||||||.||::.::  .||:::|.::.||.|:.||..|:.::||:|
Yeast   292 QRNKTTKQVRTIEKITPIESFFNFFDPPKIQNEDQDEELEEDLEERLALDYSIGEQLKDKLIPRA 356

  Fly   316 VLYYTGDIVDDEDDEDEEEYDENEEDEYDDDDAPPPKGPKS-------AGIKKQSPNDC 367
            |.::||..::.|.:|||||.||:|::|.|||........:|       ||..:|:| :|
Yeast   357 VDWFTGAALEFEFEEDEEEADEDEDEEEDDDHGLEDDDGESAEEQDDFAGRPEQAP-EC 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nap1	NP_001246485.1	NAP	55..321	CDD:279323	88/280 (31%)
NAP1	NP_012974.1	NAP	95..362	CDD:395763	88/279 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343499
Domainoid	1	1.000	153	1.000	Domainoid score	I909
eggNOG	1	0.900	-	-		E1_KOG1507
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129218
Inparanoid	1	1.050	184	1.000	Inparanoid score	I940
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53841
OrthoFinder	1	1.000	-	-		FOG0000988
OrthoInspector	1	1.000	-	-		otm46824
orthoMCL	1	0.900	-	-		OOG6_100833
Panther	1	1.100	-	-	LDO	PTHR11875
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1852
SonicParanoid	1	1.000	-	-		X426
TreeFam	1	0.960	-	-
	15	14.790