DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nap1 and Nap1l4

DIOPT Version :9

Sequence 1:	NP_001246485.1	Gene:	Nap1 / 37798	FlyBaseID:	FBgn0015268	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001272418.1	Gene:	Nap1l4 / 17955	MGIID:	1316687	Length:	386	Species:	Mus musculus

Alignment Length:	392	Identity:	174/392 - (44%)
Similarity:	240/392 - (61%)	Gaps:	44/392 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DPESCNEIEDEKSGSDCQSM-------PAYMNSVMRR-----QYLQQMVKMLPAPVQNRIVFLKN 62
            |....:.:|..|:.|:.:.:       |..:.::..|     ......::.||..|:.||..||.
Mouse     8 DGGPADSVEAAKNASNTEKLTDQVMQNPQVLAALQERLDNVSHTPSSYIETLPKAVKRRINALKQ 72

  Fly    63 LQLQHLNIEAQFFEDVYKLEQKYQVQYQPLFDKRREIIEGKVDPAEEKPQWKEPESSTDNEADAE 127
            ||::..:|||:|:|:|:.||:||...||||||||||.|.|.|:|.:.:..|     .::||.:.:
Mouse    73 LQVRCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESAW-----HSENEEEDK 132

  Fly   128 HFREALSSLKSIPKDA--------KGIPGFWLTVFRNTAIMSEMVQPHDEPAIRKLIDISIKY-D 183
            ...:..:.:....|:|        ||||.||.|:|||..::||:||.:|||.::.|.||.:|: |
Mouse   133 LAGDMKNKVVIAEKEAATVEELNPKGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSD 197

  Fly   184 NGH--SYTLEFHFDKNEYFSNSVLTKQYVLKSTVDPNDPFAFEGPEIYKCTGCTINWEKKMNLTV 246
            .|.  |:.|||||:.|:||:|.||||.|.:||..|..|||:||||||..|.||||:|:|..|:||
Mouse   198 PGQPMSFVLEFHFEPNDYFTNPVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTV 262

  Fly   247 KTIRKKQKHKERGAVRTIVKQVPTDSFFNFFSPPEVPSDQEEVDDDSQQILATDFEIGHFLRARI 311
            |||:||||||.||.||||.||||.:||||||||.:...|.|.:|:||:..||:|||||||.|.||
Mouse   263 KTIKKKQKHKGRGTVRTITKQVPNESFFNFFSPLKASGDGESLDEDSEFTLASDFEIGHFFRERI 327

  Fly   312 IPKAVLYYTGDIVDDED--------DEDEEEYDENEEDEYDDDDAPPPKGPKSAGIKKQSPNDCP 368
            :|:||||:||:.::|:|        :|:|.|.||..||| ||.|..|.|.|       ..|.:|.
Mouse   328 VPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGDEEGEDE-DDADVNPKKEP-------SQPAECK 384

  Fly   369 NQ 370
            .|
Mouse   385 QQ 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nap1	NP_001246485.1	NAP	55..321	CDD:279323	144/276 (52%)
Nap1l4	NP_001272418.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		4/19 (21%)
		NAP	65..338	CDD:395763	145/277 (52%)
		Nuclear localization signal. /evidence=ECO:0000255	265..271		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1418
eggNOG	1	0.900	-	-		E1_KOG1507
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2387
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53841
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000988
OrthoInspector	1	1.000	-	-		otm43584
orthoMCL	1	0.900	-	-		OOG6_100833
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1852
SonicParanoid	1	1.000	-	-		X426
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760