DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13562 and LPL

DIOPT Version :9

Sequence 1:	NP_001246484.1	Gene:	CG13562 / 37797	FlyBaseID:	FBgn0034928	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_000228.1	Gene:	LPL / 4023	HGNCID:	6677	Length:	475	Species:	Homo sapiens

Alignment Length:	359	Identity:	79/359 - (22%)
Similarity:	135/359 - (37%)	Gaps:	78/359 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QAAKATQNDTLAHQQRIKY-DAQKTMKVMFYKNNTKTMETSAYDDAYDLSG-----SGC--SPTD 93
            |:..|::....|..||..: |.:.       |...:|.|.:|.|..:.:.|     :.|  :.:.
Human    16 QSLTASRGGVAAADQRRDFIDIES-------KFALRTPEDTAEDTCHLIPGVAESVATCHFNHSS 73

  Fly    94 KFAIVLHGW-IQSCSDEWALSLIERLSYYR--GGCVICIDYSVVASSSYMRLYTNFDTLTGAISS 155
            |..:|:||| :....:.|...|:..| |.|  ...||.:|:...|...| .:...:..|.|...:
Human    74 KTFMVIHGWTVTGMYESWVPKLVAAL-YKREPDSNVIVVDWLSRAQEHY-PVSAGYTKLVGQDVA 136

  Fly   156 IILTLFRQGFD-P-KRGYMFGFSFGGQLASAVGRSLRPHHIIESIDTCDMAGPGF---------- 208
            ..:....:.|: | ...::.|:|.|...|...| || .:..:..|...|.|||.|
Human   137 RFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAG-SL-TNKKVNRITGLDPAGPNFEYAEAPSRLS 199

  Fly   209 ----DPIAVDHS-------------KAGKHVQCFHSSRDKGTFVYSCHRNI-----MLGSCGLKQ 251
                |.:.|.|:             |...||..:.:.   |||...|  ||     ::...||..
Human   200 PDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNG---GTFQPGC--NIGEAIRVIAERGLGD 259

  Fly   252 PSVASQLHLGSHGLCVDIYINTF---DYPFYAVNYTPPE------CFTWQKTAKIPDGYTVGYEE 307
               ..||...||...:.::|::.   :.|..|...:..|      |.:.:|..    ...:|||.
Human   260 ---VDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNR----CNNLGYEI 317

  Fly   308 N-FDSQVTGQIFVPTSLHYPYNLSKKQLKLLTKG 340
            | ..::.:.::::.|....||.:...|:|:...|
Human   318 NKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSG 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13562	NP_001246484.1	Abhydrolase	64..>208	CDD:304388	38/155 (25%)
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:30559189	32..53		5/27 (19%)
		Lipase	33..473	CDD:332983	74/342 (22%)
		Essential for determining substrate specificity. /evidence=ECO:0000269\|PubMed:7592706	243..266		7/27 (26%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269\|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269\|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:26725083, ECO:0000269\|PubMed:30559189	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010