DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13562 and Lpl

DIOPT Version :9

Sequence 1:	NP_001246484.1	Gene:	CG13562 / 37797	FlyBaseID:	FBgn0034928	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus

Alignment Length:	339	Identity:	76/339 - (22%)
Similarity:	127/339 - (37%)	Gaps:	70/339 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DAQKTMKVMFYKNNTKTMETSAYDDAYDLSG-----SGC--SPTDKFAIVLHGW-IQSCSDEWAL 112
            ||.:....:..|...:|.|.:|.|..:.:.|     |.|  :.:.|..:|:||| :....:.|..
Mouse    29 DAGRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVP 93

  Fly   113 SLIERLSYYR--GGCVICIDYSVVASSSYMRLYTNFDTLTGAISSIILTLFRQGFD-P-KRGYMF 173
            .|:..| |.|  ...||.:|:...|...| .:...:..|.|...:..:....:.|: | ...::.
Mouse    94 KLVAAL-YKREPDSNVIVVDWLYRAQQHY-PVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLL 156

  Fly   174 GFSFGGQLASAVGRSLRPHHIIESIDTCDMAGPGF--------------DPIAVDHS-------- 216
            |:|.|...|...| || .:..:..|...|.|||.|              |.:.|.|:
Mouse   157 GYSLGAHAAGVAG-SL-TNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGR 219

  Fly   217 -----KAGKHVQCFHSSRDKGTFVYSCHRNI-----MLGSCGLKQPSVASQLHLGSHGLCVDIYI 271
                 |...||..:.:.   |||...|  ||     ::...||..   ..||...||...:.::|
Mouse   220 SIGIQKPVGHVDIYPNG---GTFQPGC--NIGEAIRVIAERGLGD---VDQLVKCSHERSIHLFI 276

  Fly   272 NTF---DYPFYAVNYTPPE------CFTWQKTAKIPDGYTVGYEEN-FDSQVTGQIFVPTSLHYP 326
            ::.   :.|..|......|      |.:.:|..    ...:|||.| ..::.:.::::.|....|
Mouse   277 DSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNR----CNNLGYEINKVRAKRSSKMYLKTRSQMP 337

  Fly   327 YNLSKKQLKLLTKG 340
            |.:...|:|:...|
Mouse   338 YKVFHYQVKIHFSG 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13562	NP_001246484.1	Abhydrolase	64..>208	CDD:304388	39/155 (25%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		4/20 (20%)
		lipo_lipase	33..472	CDD:132274	74/335 (22%)
		Pancreat_lipase_like	37..334	CDD:238363	69/312 (22%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		7/27 (26%)
		PLAT_LPL	341..465	CDD:238856	3/11 (27%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100