DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpt and SETD1A

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_055527.1	Gene:	SETD1A / 9739	HGNCID:	29010	Length:	1707	Species:	Homo sapiens

Alignment Length:	515	Identity:	93/515 - (18%)
Similarity:	160/515 - (31%)	Gaps:	174/515 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   850 EGVNILRKKRQRNLQKLGIGG-FSVRNRGLKKDSEETTAVDQINSLM------TMDKKKKIIRKK 907
            |.|.||...|.|  :.||:.. .....||.|    ||.....:.|:|      .:|     |:.:
Human   121 EEVEILLHPRTR--KHLGLARVLFTSTRGAK----ETVKNLHLTSVMGNIIHAQLD-----IKGQ 174

  Fly   908 QKNKLIEAYPVYLQEAFFGKPLLEGGELVM-------ADTDSSDEIDASMKVYFTRPEGK----- 960
            |:.|.   |.:.:..::..:.:..||:.:.       |.|::::....|.......|.|.
Human   175 QRMKY---YELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGT 236

  Fly   961 ----SPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQ----NKNGTTP-------- 1009
                :|.:||| :.:.|            :.:..:.|.|..|...|    ...|:||
Human   237 PGNGTPCSQDT-SFSSS------------RQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYS 288

  Fly  1010 ---VSNVFDPLQAEIS-NTVFANRH------------------PLDALASPNVPELDMANSVSTV 1052
               .|..|.|.::|.| ...|:.||                  ...|.:|.:...|..::|.|:.
Human   289 SSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSS 353

  Fly  1053 PSAEVIEKPMRESPAVLVD-------SFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQL-----QF 1105
            .|:..........||....       :...|.:..:|:.      .|.....|.|::.     .:
Human   354 SSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEP------PGAPFAENTAERFPPSYTSY 412

  Fly  1106 RQQAPQNANKQNMQTIMSQV----------------------VLQTEKRPEEEQKVVEPVTETLN 1148
            ....|.....|:.:...|:.                      .::|..||....:...|..||.|
Human   413 LPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTN 477

  Fly  1149 AGTQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFL 1213
                                  .:|.:|  :|.:|       :.|.:.:||..||     |..||
Human   478 ----------------------ESVPFA--QHSSL-------DSRIEMLLKEQRS-----KFSFL 506

  Fly  1214 ----QKAKDNRS-ALRQRREQNKIPM---------PPKPQKQEEMGRVWKQPPKLKEDQP 1259
                ::.::|.| .|..|...:::|.         ||.|...|::.......|....:.|
Human   507 ASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESP 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	28/176 (16%)
		HMG	1173..1231	CDD:197700	16/62 (26%)
SETD1A	NP_055527.1	RRM_Set1A	92..186	CDD:240992	20/78 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..308		24/126 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..363		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..486		17/134 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..655		12/61 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..854
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..1251
		DNA_pol3_delta2	<1070..>1130	CDD:331068
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1264..1293
		HCFC1-binding motif (HBM)	1299..1303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1307..1417
		Interaction with CFP1	1415..1450
		N-SET	1425..1562	CDD:314603
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269\|PubMed:17998332	1450..1537
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1472..1499
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	1492..1497
		SET	1568..1691	CDD:214614
		PostSET	1691..1707	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030