DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and KAT2B

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_003875.3	Gene:	KAT2B / 8850	HGNCID:	8638	Length:	832	Species:	Homo sapiens

Alignment Length:	857	Identity:	158/857 - (18%)
Similarity:	276/857 - (32%)	Gaps:	290/857 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 LRPVISAIPKYGWKCNRCRVCTD----CGSRT----------PGGGSSSRWH------------- 318
            |.|..:|:|....:.:.|.....    ||..|          ||||.|:|..
Human    25 LPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAK 89

  Fly   319 -----SHYTIC---DSC----YQQRNKG----------------FSCPICQKAYRA-ASHKEMVK 354
                 ..|:.|   :||    ::..|..                .||..|..|..| .||.|.|.
Human    90 KLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVS 154

  Fly   355 CSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSE 419
            ....|:.:....|.|...|..||:::.:....|.                    .:...:..|..
Human   155 EEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYF--------------------YLFKLLRKSIL 199

  Fly   420 QLSLKEIELDPLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTR 484
            |           .|||.::.|   |.|.|..:|    .|:......||.::...:..  |:|.|.
Human   200 Q-----------RGKPVVEGS---LEKKPPFEK----PSIEQGVNNFVQYKFSHLPA--KERQTI 244

  Fly   485 GKGRQLALPTIS-------SDRCLSRSMETDLTSDKK-----LLLCSARDKFIQAQDICVMCGSL 537
            .:..::.|..|:       |.|.| ||...|::..|:     |..|          ::...|.||
Human   245 VELAKMFLNRINYWHLEAPSQRRL-RSPNDDISGYKENYTRWLCYC----------NVPQFCDSL 298

  Fly   538 -GIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKND----EARLLLCD 597
             ..|:..|.                   .|.:|:..:..:...:.|...::.|    |.|.|:..
Human   299 PRYETTQVF-------------------GRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILT 344

  Fly   598 ECD-----ISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGR-------NPTEK----SEFGDSNM 646
            ...     :...:|..|.|:       |...|.:...:..:       ||...    |....|:.
Human   345 HFPKFLSMLEEEVYSQNSPI-------WDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSS 402

  Fly   647 LECPSCTSQSSCPVCKVS----YSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKC 707
            ||.|:  :.||.|.||.|    .:.||                   ..::|    |::|.:
Human   403 LEQPN--AGSSSPACKASSGLEANPGE-------------------KRKMT----DSHVLE---- 438

  Fly   708 RCSTRSTNSLAD--AKFGNEDSLAIT-------PQGSKPFVHITASSGPSFDSKSGAERNHPTLS 763
              ..:....:.|  .:..||....||       |:.:....|.........:.:.|....|  :.
Human   439 --EAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFH--VV 499

  Fly   764 GDMPESAP--EALHWIDGVCLSESGLGMIKSLSTEIKR--KRKMRQALGNGKDGQLEAAAEEALE 824
            |:.....|  :.|.|:         :|:....|.::.|  |..:.:.:.:.|        .:.|.
Human   500 GNSLNQKPNKKILMWL---------VGLQNVFSHQLPRMPKEYITRLVFDPK--------HKTLA 547

  Fly   825 KYKDGMVWDG-TENAIP-EGFT------ISINDE----GVNILRKKRQRNLQ-----------KL 866
            ..|||.|..| .....| :|||      ::.|::    |.:::...::.:::           :.
Human   548 LIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEY 612

  Fly   867 GIG-----GFS-------VRNRGLKKDSEETTAVD-QINSLMTMDKKKKIIRKKQK--NKLIEAY 916
            .||     |||       .:..|..||.|..|.:. ::|..:...:...||:|:::  .||||..
Human   613 AIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERK 677

  Fly   917 PVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFT--RPEG----KSPANQDTLAVNKSPA 975
            ...:::.:.|....:.|...:       .|::...:..|  :|.|    |.|.:.|.|      .
Human   678 QAQIRKVYPGLSCFKDGVRQI-------PIESIPGIRETGWKPSGKEKSKEPRDPDQL------Y 729

  Fly   976 KTVKKVKAELKT 987
            .|:|.:..::|:
Human   730 STLKSILQQVKS 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985	4/16 (25%)
		PHD_SF	337..392	CDD:304600	15/55 (27%)
		PHD4_KMT2C_like	530..578	CDD:276987	7/48 (15%)
		PHD5_KMT2C_like	580..625	CDD:276988	9/53 (17%)
		PHD6_KMT2C_like	657..707	CDD:276989	10/53 (19%)
		NHP6B	1101..>1237	CDD:227935
		HMG	1173..1231	CDD:197700
KAT2B	NP_003875.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		6/28 (21%)
		PCAF_N	75..325	CDD:368925	55/319 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..436		15/65 (23%)
		COG5076	487..826	CDD:227408	54/287 (19%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:10393169	574..576		0/1 (0%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:10393169	581..587		0/5 (0%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:10393169	612..615		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	706..725		5/18 (28%)
		Bromo_gcn5_like	727..826	CDD:99941	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900