DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpt and YPL216W

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_015108.1	Gene:	YPL216W / 855885	SGDID:	S000006137	Length:	1102	Species:	Saccharomyces cerevisiae

Alignment Length:	1015	Identity:	174/1015 - (17%)
Similarity:	309/1015 - (30%)	Gaps:	329/1015 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 SHYTICDSCYQQRNKGFSCPICQ-KAYRAASH--KEMVKCSWCNKFVHSTCDEEADLTAYHKKKE 380
            |.|.|.: |..:.:||.:..:.| :..|..||  |.::.| :.|:.:....::|.  ..:..|:|
Yeast   182 SLYLITE-CLNRESKGAALIVGQNEIKRPESHFSKFIIAC-FLNEILIKVSNKEH--APWRVKQE 242

  Fly   381 QNPDYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSEQLSL-----KEIELDPLEGKPTMDPS 440
            ....|| |.|.|..|         .||.:. ..|:|||.:|..     .|.:::|.:.|.|.:.|
Yeast   243 YIERYD-VNPKCSPN---------MIDYLP-DRMNSSSSELYTPLTIPPESDVEPADWKETSETS 296

  Fly   441 SDELHKLPTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKG----RQLAL--PTISSDR 499
            .         ..:..|:.::....:..:....:...:|.......||    ::|..  |:|..:.
Yeast   297 E---------TSETSLSKIKAIDDEISVSFDHIYDNVNSLAYNDLKGTVDDKELPFTGPSIPFEN 352

  Fly   500 C--LSRSMETDLTSDKKLLLCS--ARDKFIQAQDICVMCGS-LGIE--SDSVMITCAQC------ 551
            .  |..|:|......|....||  ..::.:.........|. :|:.  :....:|..:|
Yeast   353 ISYLDSSLEYKNIDQKWFKECSQFPTERLLVVYQFLSFFGRFIGLSHFNFDQFLTTIKCTSPEAL 417

  Fly   552 -------------------------GQCYHP--------------------------YCAGVKPS 565
                                     .:.|:.                          :....|..
Yeast   418 VDEYVKINFLKTYNSKGSFTNEKPRNEIYNQVTSSNVSQREKANVFNADESQRIPSNFTRNQKMR 482

  Fly   566 RGILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISY-HIYCVNPPLETVPTGNWKCSFCTLCQ 629
            :.|..|....:..::.:|...|||:......::.:|.| .|.|....|.|....:|.|:...
Yeast   483 KFITDKSTEFVMYSIFKGKPLKNDDMEFQSYEKVNILYIDIVCSLMCLMTDNEPDWNCNLMD--- 544

  Fly   630 KCGRNPTEKSEFGDSNMLE----CPSCTSQSSCPVCKV----SYSNGEMIIQCEHCELWAHFHCD 686
                |.||:....:.|..|    ...|.:.......|:    ::|||..:|    |.|
Yeast   545 ----NWTEEKRKEEGNKTEIDIAIEKCLNYGDTSWVKLLHNKNFSNGNWLI----CLL------- 594

  Fly   687 SVNAQLTIDHYDNNVYKCFKCRCSTRSTN--SLADAKFGN-EDSLAITPQGSKPFVHITASSGPS 748
            .:..|.|.....::|.||...:....|.|  :|.|..:.| ...|:|..:....:|.:..:|..|
Yeast   595 GILQQNTHMIAYSDVAKCITKKILPLSMNFVNLGDELWDNFRKRLSIKDKIDVLWVLVDFASNFS 659

  Fly   749 FDSK-----------------SGAERNHPTLSGDMPESAPEALHWIDGVCLSESG----LGMIKS 792
            ...|                 ..|::.:..|...:.......:.....|.::..|    .|.:.:
Yeast   660 SYIKELVDKVPKLCNGIRLKLDSAKKEYIKLKRQLKTLTKNRVKLHSNVSMNRYGSDECKGKVNA 724

  Fly   793 LSTE---------------IKRKRKMRQALG---NG-------KDGQLEAAAEEALEKYKDGMVW 832
            |..:               |:...|..:.||   ||       .:|...|.:|:..|.|....:|
Yeast   725 LKVKIAYLMEDIAFLEAKLIQSDIKRLEILGKDRNGNRYYWMDSNGSSSAISEKNEELYNCCFLW 789

  Fly   833 -----------------------------DGTENAIPEGFTISINDEGVNILRKKRQRNLQKLGI 868
                                         .||..|..|.|:|..:.:| :..:..:..|...:..
Yeast   790 VQGPSEADINFCLDVDVESLKKWELLAKAKGTAYATKEVFSIFRSTDG-SYYQIAQGENFMIINS 853

  Fly   869 GGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFG------- 926
            .|..:|              ..|.:.:    .||||.:..:..|:..:    |.|||.
Yeast   854 NGILMR--------------PTIPAFI----DKKIISETPEKLLLSHH----QWAFFNDIEDIHM 896

  Fly   927 -----KPLLEG-GELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAEL 985
                 ..|.|. |:|..|.|...|.|:.|.|..|                         |:|..:
Yeast   897 LVDRLDDLRENEGQLKKALTSKMDRIEVSYKQQF-------------------------KIKRRI 936

  Fly   986 KTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVS 1050
            :.:.                                   .|...|.|........|||....:..
Yeast   937 ECDE-----------------------------------TFKKNHKLLKNNEFTFPELKRIETTC 966

  Fly  1051 T-----VPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLG--GNTLVNPAQQLQFRQQ 1108
            |     ..:.|.|.|.:..:          .|.|..|....:..:||  ...|:...|.|.:
Yeast   967 TSNGQHFSNMEKISKKLSRT----------KNDLVLEAILKDVAHLGECERALLKKQQNLIY--- 1018

  Fly  1109 APQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLN 1148
             |.|.:.:.::||..:.:::|:::.:|     :.:|:.||
Yeast  1019 -PLNFHFEQLRTIDLEFIVETKRKRQE-----DILTKLLN 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600	14/57 (25%)
		PHD4_KMT2C_like	530..578	CDD:276987	8/107 (7%)
		PHD5_KMT2C_like	580..625	CDD:276988	12/45 (27%)
		PHD6_KMT2C_like	657..707	CDD:276989	12/53 (23%)
		NHP6B	1101..>1237	CDD:227935	11/48 (23%)
		HMG	1173..1231	CDD:197700
YPL216W	NP_015108.1	WAC_Acf1_DNA_bd	26..124	CDD:287503
		DDT	375..435	CDD:214726	4/59 (7%)
		WHIM1	626..667	CDD:292246	9/40 (23%)
		WHIM2	750..793	CDD:292247	10/42 (24%)
		WHIM3	885..923	CDD:292248	10/37 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900