DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and RSC4

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_012933.4	Gene:	RSC4 / 853877	SGDID:	S000001716	Length:	625	Species:	Saccharomyces cerevisiae

Alignment Length:	495	Identity:	89/495 - (17%)
Similarity:	175/495 - (35%)	Gaps:	131/495 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   793 LSTEIKRK-------------RKMRQALGNGKDGQLEAAAEEALE---KYKDGMVWDGTENAIPE 841
            :::|:|.|             :|:.|||       |.|::.:.|:   |..:..:....::.:||
Yeast   167 INSEVKAKLLHYLNKLVDATEKKINQAL-------LGASSPKNLDDKVKLSEPFMELVDKDELPE 224

  Fly   842 GFTISINDEGVNILRKKRQRNLQKLGIGGFS------------VRNRGLKKD------SEETTAV 888
            .:.|..:...::|::       |.|.||.:|            .:|..:..|      .:.||..
Yeast   225 YYEIVHSPMALSIVK-------QNLEIGQYSKIYDFIIDMLLVFQNAHIFNDPSALIYKDATTLT 282

  Fly   889 DQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFF----GKPLLEGGELVMA-------DTDS 942
            :..|.|:..:...::....::.::...:..:..|.:.    |.|...|...:.|       :::.
Yeast   283 NYFNYLIQKEFFPELQDLNERGEINLEFDKFEFENYLAIGGGGPAAAGALAISALDNDIEPESNR 347

  Fly   943 SDEIDASMKVYFTRPEG------KSPANQDTLAVNKSPAKTVKK---VKAELKTENKTVFIQQMP 998
            .|.||.: ...|...||      :|...:|.|....:..|.:.|   |::|:|.|..|....:..
Yeast   348 EDLIDQA-DYDFNHFEGLGNGYNRSLLTEDYLLNPNNFKKLIAKPETVQSEVKNERSTTSDIEKT 411

  Fly   999 MGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMR 1063
            ..:::::...|..||...:|.|:.:  .:.:|.::......:.::.:.:|.:....|   .||:.
Yeast   412 NSLESEHLKIPKYNVIKSMQKEMQS--LSEQHTMEYKPYKLIQQIYIFSSKNLYSQA---TKPLL 471

  Fly  1064 ES-PAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQAPQ---------------- 1111
            .| |:.        ||...|..|:      ||.|........|..|..|
Yeast   472 GSRPSC--------NQNWVEYIFN------GNELSQNENAFSFMLQPMQTFLTLQSHLTSSLKDT 522

  Fly  1112 ----NANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVT----ETLNAGTQKTAEKMRKDEDLGLMA 1168
                ..||:.:::..|.|.....:..::|..|:...|    |.|..|.....:.:..|.|
Yeast   523 ETLLTINKEPVKSRTSNVNSNLSQPQQQENDVIGNDTKQDIENLTIGGGNNNDIVGNDND----- 582

  Fly  1169 TISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEK 1208
                      :..|:.|:|.|   |..:.|......|.:|
Yeast   583 ----------KRNNITEIFDI---RLSEGLNHLMFRCEDK 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	23/132 (17%)
		HMG	1173..1231	CDD:197700	8/36 (22%)
RSC4	NP_012933.4	COG5076	40..423	CDD:227408	47/270 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900