Protein Alignment Lpt and SET2

DIOPT Version :9

• Sequence 1: NP_611847.2
• Gene: Lpt / 37795
• FlyBaseID: FBgn0263667
• Length: 1482
• Species: Drosophila melanogaster
• Sequence 2: NP_012367.2
• Gene: SET2 / 853271
• SGDID: S000003704
• Length: 733
• Species: Saccharomyces cerevisiae
• Alignment Length: 824
• Identity: 149/824 - (18%)
• Similarity: 270/824 - (32%)
• Gaps: 280/824 - (33%)

  Fly   789 MIKSLSTEIKRKRKMRQALGNGKDG--------QLEAAAEEALEKYK--DGMVW----------- 832
            |.|:.|.......|  :.|.|..:|        |.....||||.|::  |..::
Yeast     1 MSKNQSVSASEDEK--EILNNNAEGHKPQRLFDQEPDLTEEALTKFENLDDCIYANKRIGTFKNN 63

  Fly   833 ------------DGTENAIPEG------FTI--SIND---EGVNILRKKRQRNLQKLGIGGFSVR 874
                        ||..:|..|.      .|:  .:||   ...|..:.:|.:..|...|..|..:
Yeast    64 DFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTK 128

  Fly   875 NRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQ-KNKLIEAYPVYLQEAFFGKPLLEGGELVMA 938
            ::|....:|:....:|    ...:.|.::|.:.: :::||:....:.:..:|  .:|:.||.:.|
Yeast   129 HKGYGVRAEQDIEANQ----FIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYF--MMLQNGEFIDA 187

  Fly   939 DTDSS-------------------------------------DEID----------ASMKVYFTR 956
            ....|                                     :||.          .:.|.|...
Yeast   188 TIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEE 252

  Fly   957 PE------GKS--------PAN-QDTLAVNKSPAK---TVKKVKAE--LKTENKTV---FIQQMP 998
            |.      ||:        |.| .|.|.|..|..|   .:||:..|  :|.||:.:   |:|.:.
Yeast   253 PNCIGFLGGKTQTDAASLLPQNIADALGVTVSMEKKWLKLKKLSGEPIIKNENENINIEFLQSLE 317

  Fly   999 MGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAE---VIEK 1060
            :                              .|:|   ||    :|:...:|.:...:   :..|
Yeast   318 V------------------------------QPID---SP----VDVTKIMSVLLQQDNKIIASK 345

  Fly  1061 PMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQAPQNANKQNMQTIMSQV 1125
            .::....:..||..           |..:.|.|.|..:...:| |..:.||...|.|
Yeast   346 LLKRLFTIDDDSLR-----------HQAIKLHGYTCFSKMLKL-FITEQPQVDGKGN-------- 390

  Fly  1126 VLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIW 1190
              :||   |::.|.::.:.:.|....:.|...:...:...::.|:.|             .||..
Yeast   391 --ETE---EDDIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPA-------------KFPFL 437

  Fly  1191 NDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLK 1255
            ...|.::|::|......|:.    ..||...|..:..:..::.:||..:...|.||.
Yeast   438 KPNCDELLEKWSKFETYKRI----TKKDINVAASKMIDLRRVRLPPGWEIIHENGRP-------- 490

  Fly  1256 EDQPNMFVTYNGNAYDMGNY-VGGSAQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHTTAASTL 1319
                   :.||.......:| ..||::..|:..|                    |||::.::|.:
Yeast   491 -------LYYNAEQKTKLHYPPSGSSKVFSSRSN--------------------TQVNSPSSSGI 528

  Fly  1320 KMT--TVDNRL-ELNTAVYGTEPIGDKKL---RNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQ 1378
            ..|  .:|::. :|:...|  |....|:|   |..|::...|. |......|.|.|:  |..:::
Yeast   529 PKTPGALDSKKHKLSDEEY--ERKKQKRLEYERIALERAKQEE-LESLKQKLKLENE--RKSVLE 588

  Fly  1379 NTPITQNNPMLSISGKSQPSEGRSLEQDVKLGEPQEA-------TSSAVELE---NVGFSDLLGG 1433
            :           |..::...:....|:..||.|.:||       .|.:..||   |..|:..:..
Yeast   589 D-----------IIAEANKQKELQKEEAKKLVEAKEAKRLKRKTVSQSQRLEHNWNKFFASFVPN 642

  Fly  1434 LGEGDDDDLLKSLTSEMGDDFNILEYADPELDVNVLNSLDFDDN 1477
            |       :.|:..|:..|..||.:.|...:.:.....|..|.:
Yeast   643 L-------IKKNPQSKQFDHENIKQCAKDIVKILTTKELKKDSS 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	24/135 (18%)
		HMG	1173..1231	CDD:197700	9/57 (16%)
SET2	NP_012367.2	AWS	64..119	CDD:197795	9/54 (17%)
		SET_SETD2	119..260	CDD:380949	20/146 (14%)
		SET	215..695	CDD:225491	110/602 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030