DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and ITC1

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_011382.1	Gene:	ITC1 / 852744	SGDID:	S000003101	Length:	1264	Species:	Saccharomyces cerevisiae

Alignment Length:	508	Identity:	100/508 - (19%)
Similarity:	186/508 - (36%)	Gaps:	131/508 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   788 GMIKSLSTEIKRKRKMRQALGNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGV 852
            |.|:|...::.|:.|...|:.:...|.|: |.:|.|.|         |:...|..       :|.
Yeast   769 GQIRSERFKVARELKTEAAVLSNLQGDLQ-AIQEKLNK---------TDENTPSA-------DGA 816

  Fly   853 NILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTA--VDQINSLMTMDKKKKIIRKKQKN-KLIE 914
            :                         |||..|:.:  :|    |:.::||:|:|.::.|. :.::
Yeast   817 D-------------------------KKDDSESNSEPID----LIIIEKKQKLIEEQDKKVQALQ 852

  Fly   915 AYPVYLQEAFFG------KPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKS 973
            :...:|....|.      |||               .:|.....||.......|..|....:|::
Yeast   853 SDKNFLDNCLFENDLQRLKPL---------------GLDRYGNRYFWLDHNGVPFPQYPAGMNET 902

  Fly   974 PAKT-----------VKKVKAELKTENKTVFIQQMP--MGIQNKNGTTPVS-NVFDPLQAEISNT 1024
            |...           ::..||........|..:|:.  ..|:|..|.:..: .||.     ||.|
Yeast   903 PKSNNSLSYHSGRLLIQGPKASSAKFFLNVSDEQLSNWQKIRNSEGISEATREVFG-----ISKT 962

  Fly  1025 VFANRHPLDALASPNVPELDMANSVSTV-PSAE---VIEKPMRESPAVLV---DSFMVPNQLPQE 1082
            ...:.:.::     |..|:::.:|...| |..|   :.:|.|.|:|:.|:   |.:...::|...
Yeast   963 SSGSYNYVE-----NGIEVELLDSNDRVNPLIELTPIQKKIMDETPSRLLLSPDQWYCIDKLEDL 1022

  Fly  1083 QKFHNQLYLGGN------TLVNPAQQ-----LQFRQQA-PQNANKQNMQTIMSQVVLQTEKRPEE 1135
            .:..:.|...|.      ..:.|..:     |..|..| ...|..:|.:.::.:  |:..:..|.
Yeast  1023 SRIMDWLDNWGRKEHDLLRQIRPIMERIKSSLSLRDHALSLTAFTKNEEKLLKE--LENNEFTEN 1085

  Fly  1136 EQKVVEPVTETLNAG------TQKTAEKMRK---DEDLGLMATISAVLYANTEHPNLKELFPIWN 1191
            |..|.....:..|:|      .|..||:.|:   ||.|.::|.....|..:::..|:........
Yeast  1086 ELNVDSMDVDDKNSGVKSEVDVQVDAEEKREAVIDEKLEVIADELMKLDDSSKTRNVLNRIQELE 1150

  Fly  1192 DRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEEM 1244
            |:..::|::.:|:.|.::       ...|...|..|::.||....|..||.|:
Yeast  1151 DQRDELLEQKKSIINSQR-------PGARILARSERKRTKISRGNKVNKQIEI 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	30/150 (20%)
		HMG	1173..1231	CDD:197700	9/57 (16%)
ITC1	NP_011382.1	WAC_Acf1_DNA_bd	24..124	CDD:402251
		DDT	423..483	CDD:214726
		WSD	869..952	CDD:406128	17/97 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900