DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and KMT2D

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_011537072.1	Gene:	KMT2D / 8085	HGNCID:	7133	Length:	5556	Species:	Homo sapiens

Alignment Length:	2180	Identity:	418/2180 - (19%)
Similarity:	617/2180 - (28%)	Gaps:	1084/2180 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PGKVCCLCNLGEKSALGQGEILQLKAPAPAEIKDKYPTDRLREDGSRLLYGPKQAASSSGDCHYE 90
            |.:.|.|||.||.|..||.|:.:.:.|.      .:|...:...|..  .||.:|...|.|
Human    62 PVRRCALCNCGEPSLHGQRELRRFELPF------DWPRCPVVSPGGS--PGPNEAVLPSED---- 114

  Fly    91 LDKIGQPDVVHPAEFLDE--GFVYVHRMCIMWSL-----RKSQISDADGAYFATHFAEFLEQKCN 148
            |.:||.|:.:.||. |.|  |..:.|..|..||.     ...::...|.|.|:.     :.|:|:
Human   115 LSQIGFPEGLTPAH-LGEPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSG-----ISQRCS 173

  Fly   149 FCGRYGASINCKM-NCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSL 212
            .|.|.||||.|:. .|.:::|:|||.|:|..|.:::..:.|.||......:   ....|..|...
Human   174 HCTRLGASIPCRSPGCPRLYHFPCATASGSFLSMKTLQLLCPEHSEGAAYL---EEARCAVCEGP 235

  Fly   213 GDLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYH 277
            |:|..|..|::||.|:|..|:..|.....|:||.|..|..||.|| :..||:|.:.||.|.|.||
Human   236 GELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACR-KPGNDSKMLVCETCDKGYH 299

  Fly   278 ASCLRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRN---------- 332
            ..||:|.:..:|.:.|||..||||..||:.:.....:|.|..:|::|..|::.:.
Human   300 TFCLKPPMEELPAHSWKCKACRVCRACGAGSAELNPNSEWFENYSLCHRCHKAQGGQTIRSVAEQ 364

  Fly   333 -----KGFSCP---------------ICQ------------------------------------ 341
                 ..||.|               .||
Human   365 HTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQ 429

  Fly   342 ---------------------------------KAYRAASHKEMVKCSWCNKFVH---------- 363
                                             :|.|.:...|.:..|...:.:|
Human   430 LEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPL 494

  Fly   364 ----------------------------------------------------------------- 363

Human   495 SPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPE 559

  Fly   364 ----------------------------------------------------------------- 363

Human   560 ELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEAS 624

  Fly   364 ----------------------------------------------------------------- 363

Human   625 RLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRL 689

  Fly   364 ---------------------------------------------------------------ST 365
                                                                           |.
Human   690 SPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSP 754

  Fly   366 CDEEADLTAYHKKKEQNPDYDYVC-------PNCKSNSSGPGSSQQTIDSIVLSA---------- 413
            ..||..|:...::...:|..:..|       |:....:.||..|.|. :.:.||.
Human   755 RPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQP-EELHLSPQTEEPHLSPV 818

  Fly   414 --------------MDSSSEQLSLK----------EIELDPLE---------------------- 432
                          :...||:..|.          |:|..||.
Human   819 PEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLF 883

  Fly   433 --------------------GKPTMDPSSDELHKLPTGKKKV----------------------- 454
                                |:|.:.|..:||...|:|:..:
Human   884 PPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAP 948

  Fly   455 ----------------------------------------------------------------- 454

Human   949 PALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPAS 1013

  Fly   455 ----------------------------C---------------LTSVRGRSGKFVLHRM----- 471
                                        |               :..|.|.|.:..||.|
Human  1014 PILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKV 1078

  Fly   472 ----------------------------------------------------------------- 471

Human  1079 SEPECPALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGS 1143

  Fly   472 ----------------------------------------------------------------- 471

Human  1144 LASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEI 1208

  Fly   472 ----------------------------------GVMSQIN------------------------ 478
                                              ||.:.::
Human  1209 SNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLC 1273

  Fly   479 ----------------KKRST---------------------------RGKGR-----------Q 489
                            ::||:                           ||:||           .
Human  1274 DAGTAISGGKAEGEKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHGGRGRGRARLKSTASSIET 1338

  Fly   490 LALPTISSDRCLSRSMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQC 554
            |.:..|.|........|.|.|....::|.|..|||:..||:||:|||.|..::..::.|:||.||
Human  1339 LVVADIDSSPSKEEEEEDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQC 1403

  Fly   555 YHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGN 619
            |||||...|.::.:|.|||||::|.|||.||:.:|.:||||||:||||||.||::|||.|||.|.
Human  1404 YHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGG 1468

  Fly   620 WKCSFCTLCQKCG-RNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHF 683
            |||.:|..|.:|| .:|....|:.:| ...|..|.|..:||:|...|...:::|||.|||.|.|.
Human  1469 WKCKWCVSCMQCGAASPGFHCEWQNS-YTHCGPCASLVTCPICHAPYVEEDLLIQCRHCERWMHA 1532

  Fly   684 HCDSVNAQLTIDHYDNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPS 748
            .|:|:..:..::...:..:.|..|:                       |...||...:.
Human  1533 GCESLFTEDDVEQAADEGFDCVSCQ-----------------------PYVVKPVAPVA------ 1568

  Fly   749 FDSKSGAERNHPTLSGDMPESAPEALHW-IDGVCLSESGLGMIKSLSTEIKRKRKMRQ------- 805
                       |.....|....||..:: .:||.|:|:|:.::::|:.....||:.|:
Human  1569 -----------PPELVPMKVKEPEPQYFRFEGVWLTETGMALLRNLTMSPLHKRRQRRGRLGLPG 1622

  Fly   806 -----------ALG--NGKDGQLEA----AAEEALEKYK-----DGMVWDGTENAIPEGFTISIN 848
                       |||  :.|||.|:.    ..|..:|..:     :|.|....|....|      .
Human  1623 EAGLEGSEPSDALGPDDKKDGDLDTDELLKGEGGVEHMECEIKLEGPVSPDVEPGKEE------T 1681

  Fly   849 DEGVNILRKKRQRNLQKLGIGGFSVRNR----GLKK---------------DSEETT-------- 886
            :|.     |||:|...:.|||||.||.|    ..||               |..||.
Human  1682 EES-----KKRKRKPYRPGIGGFMVRQRKSHTRTKKGPAAQAEVLSGDGQPDEGETVIPADLPAE 1741

  Fly   887 -AVDQINSLMTMDKKKKIIRK-KQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDAS 949
             ||:|  ||...|:|||..|: ::|:||.:.:|.|||||||||.||                |.|
Human  1742 GAVEQ--SLAEGDEKKKQQRRGRKKSKLEDMFPAYLQEAFFGKELL----------------DLS 1788

  Fly   950 MKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVF 1014
            .|..|....|:......|           .|.|.:..:|.|     ::|...:..:|
Human  1789 RKALFAVGVGRPSFGLGT-----------PKAKGDGGSERK-----ELPTSQKGDDG-------- 1829

  Fly  1015 DPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVDSF--MVPN 1077
                .:|::   .....|:..|....|| |.....|.|||..  |||......:|....  :...
Human  1830 ----PDIAD---EESRGLEGKADTPGPE-DGGVKASPVPSDP--EKPGTPGEGMLSSDLDRISTE 1884

  Fly  1078 QLPQ-EQKFHNQLY-----------LGGNT--LVNPAQQLQ--FRQ------QAPQNANKQNMQT 1120
            :||: |.|...||:           ||..|  |......||  |.|      ..|.::...:...
Human  1885 ELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLEGSRTPLQRPFLQGGLPLGNLPSSSPMDSYPG 1949

  Fly  1121 IMSQVVLQTEKR-----PEEEQ--------------KVVEPVTETLNAG---TQKTAEKMRKDED 1163
            :.....|.:.:|     ||..:              ....|.||....|   .|::.::..|||:
Human  1950 LCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEE 2014

  Fly  1164 LGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALR---- 1224
            ||.::|||.|||||...||||:.:|.|:.|||||:|.||.:....|||:||||||||:|.|
Human  2015 LGQLSTISPVLYANINFPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKV 2079

  Fly  1225 QRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQP 1259
            |::.:::|      .||.::|.:.:     |.|:|
Human  2080 QKQAESQI------NKQTKVGDIAR-----KTDRP 2103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	26/87 (30%)
		PHD1_KMT2C_like	205..250	CDD:276984	16/44 (36%)
		PHD2_KMT2C_like	252..298	CDD:276985	20/45 (44%)
		PHD_SF	337..392	CDD:304600	15/413 (4%)
		PHD4_KMT2C_like	530..578	CDD:276987	23/47 (49%)
		PHD5_KMT2C_like	580..625	CDD:276988	30/44 (68%)
		PHD6_KMT2C_like	657..707	CDD:276989	15/49 (31%)
		NHP6B	1101..>1237	CDD:227935	56/169 (33%)
		HMG	1173..1231	CDD:197700	33/61 (54%)
KMT2D	XP_011537072.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8246
eggNOG	1	0.900	-	-		E2759_KOG4443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	630	1.000	Inparanoid score	I853
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39671at33208
OrthoFinder	1	1.000	-	-		FOG0002860
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102575
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X2220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.890