DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and BRD3

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_031397.1	Gene:	BRD3 / 8019	HGNCID:	1104	Length:	726	Species:	Homo sapiens

Alignment Length:	652	Identity:	121/652 - (18%)
Similarity:	191/652 - (29%)	Gaps:	249/652 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   957 PEGK---------SPANQDTLAVNK-SPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTT-PV 1010
            |:||         |...|...||:. |||...:.|.   .|.::|..|...|:.....|.|: ||
Human   152 PKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVP---PTVSQTPVIAATPVPTITANVTSVPV 213

  Fly  1011 SNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSV-----------STVPSAEVIEKPMRE 1064
            .....|                ...|:|.||.:.....|           :|.|:...|.....|
Human   214 PPAAAP----------------PPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSE 262

  Fly  1065 SPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQAPQNANKQN--------MQTI 1121
            ||..|.|        |::.|...:...||..:..|.:.|: ..:.||:|.|:.        ..:|
Human   263 SPPPLSD--------PKQAKVVARRESGGRPIKPPKKDLE-DGEVPQHAGKKGKLSEHLRYCDSI 318

  Fly  1122 MSQVV----------------------------------LQTEKR-------------------- 1132
            :.:::                                  |.|.||
Human   319 LREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLM 383

  Fly  1133 ---------PEEE--------QKVVE------------------PVTETLNAGTQKTAEKMRKDE 1162
                     |:.|        |.|.|                  |....::.|.:.:........
Human   384 FSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSS 448

  Fly  1163 DLG--------------LMATISAVLYANTEHPNLKEL--FPIWNDRCKQILKRWRSLCNEKKAP 1211
            |.|              |...:.||      |..|..|  .|:...:.|:..|.     .|||..
Human   449 DSGSSDSEEERATRLAELQEQLKAV------HEQLAALSQAPVNKPKKKKEKKE-----KEKKKK 502

  Fly  1212 FLQKAKDNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTYNGNAYDMGNYV 1276
            ..:|.|:......:..::.|: .||..|.|:      |:.|..|.:.    .|..|.....|
Human   503 DKEKEKEKHKVKAEEEKKAKV-APPAKQAQQ------KKAPAKKANS----TTTAGRQLKKG--- 553

  Fly  1277 GGSAQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHTTAASTLKMTTVD-NRLELNTAVYGTEPI 1340
            |..|.|:.::......:|...|        ::.|:           ::| |||.
Human   554 GKQASASYDSEEEEEGLPMSYD--------EKRQL-----------SLDINRLP----------- 588

  Fly  1341 GDK--KLRNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQNTPIT---------------QNNPM 1388
            |:|  ::.:::|  |.||.|..:|.      |.:.:......|.|               |..|
Human   589 GEKLGRVVHIIQ--SREPSLRDSNP------DEIEIDFETLKPTTLRELERYVKSCLQKKQRKP- 644

  Fly  1389 LSISGKSQPSEGR-SLEQDVKL---GEPQEATSSAVELENVGFSDLLGGLGEGDDDDLLKSLTSE 1449
            .|.|||.|.::.: .|.|:.|.   ...|:.:......:.....:..|....|....|..|.:||
Human   645 FSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSE 709

  Fly  1450 MG 1451
            .|
Human   710 SG 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	35/248 (14%)
		HMG	1173..1231	CDD:197700	12/59 (20%)
BRD3	NP_031397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		Bromo_Brdt_I_like	34..140	CDD:99929
		Acetylated histone H3 binding. /evidence=ECO:0000269\|PubMed:27105114	78..80
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..169		4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..305		17/76 (22%)
		Bromo_Brdt_II_like	311..412	CDD:99930	10/100 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..462		4/40 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..575		25/116 (22%)
		BET	571..635	CDD:293640	18/101 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..726		18/76 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900