DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Brd8

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_001348065.1	Gene:	Brd8 / 78656	MGIID:	1925906	Length:	954	Species:	Mus musculus

Alignment Length:	869	Identity:	154/869 - (17%)
Similarity:	261/869 - (30%)	Gaps:	320/869 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   740 HITASSGPSFDSKSGAERNHPTLSGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMR 804
            |...|:||:                 .|.|..|.|      ||:.|.:.........:.|..|..
Mouse     8 HKLLSTGPT-----------------EPWSIREKL------CLASSVMRSGDQNWVSVSRAIKPF 49

  Fly   805 QALGNGKD--GQLEAAAE--EALEKYKDGMVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQK 865
            ...|...|  .|...|::  |.||..:......|.:..:.|    ::.|..|..|..:|...|:|
Mouse    50 AEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGEVVE----TVEDVIVRKLTAERVEELKK 110

  Fly   866 LGIGGFSVRNRGLKKDSEETTA------VDQINSLMTMDKK-----KKIIRKK-----QKNKLIE 914
            : |.....|.|.||:|:|...|      :|::.:.:.|.||     .::.||.     |..:.::
Mouse   111 V-IKETQERYRRLKRDAELIQAGHMDSRLDELCNDIAMKKKLEEEEAEVKRKATDAAYQARQAVK 174

  Fly   915 AYPVYLQEAFFGKPL---LEGGELVMAD----------------TDSSDEIDASMKVYFTRPEGK 960
            ..|..|.......|:   ..||:..:.|                |..|..:.:...:..|.|.|.
Mouse   175 TPPRRLPTVMVRSPVDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGS 239

  Fly   961 SPANQD-TLAVNKSPAKTVKKVKAE----------------LKTENKTVFIQQMPM--GIQNKNG 1006
            :|.... |...:.||.|.:...||.                |.|..:.|...:||:  |..|..|
Mouse   240 APLEAPMTPITDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMPVPPGHLNSTG 304

  Fly  1007 -----------------------------------------------TTPVSNVFDPLQAEISNT 1024
                                                           |||:.          |.|
Mouse   305 VLLEVGGVLPMIHGGEIQPTTSAVAASPAASGAPTLSRLLEAGPTQFTTPLP----------SFT 359

  Fly  1025 VFANRHPL-------------DALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVP 1076
            ..|:..|:             ..:..|.:|....|.:|||..|...:.:|   .|.|.:::...|
Mouse   360 TVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAAAVSTSESGAPVSQP---EPCVPLEAVGDP 421

  Fly  1077 NQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQ---QAPQNANKQNMQTIMSQVVLQTEKRPEEEQK 1138
            :.:..... .|::    :.::|..::..||.   :||..:                 |.|..:.|
Mouse   422 HTVTVSMD-SNEI----SMIINSIKEECFRSGVAEAPGGS-----------------KAPSIDGK 464

  Fly  1139 VVEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANT-EHPNLKELFPIWNDRCKQILKRWR 1202
            ....:.|.::.....|.|::    |...:..|.|::.... :||.:.::..:         :...
Mouse   465 EDLDLAEKMDIAVSYTGEEL----DFETVGDIIAIIEDKVDDHPEVLDVAAV---------EAAL 516

  Fly  1203 SLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTYNG 1267
            |.|.|...|                  ..:|.|            |:.|.:.:.|:|
Mouse   517 SFCEENDDP------------------QSLPGP------------WEHPIQQERDKP-------- 543

  Fly  1268 NAYDMGNYVGGSAQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHTTAASTLKMTTVDNRLELNT 1332
                              .|.|...|                        |:|...:|.....|.
Mouse   544 ------------------VPLPAPEM------------------------TVKQERLDFEESENK 566

  Fly  1333 AVYGTEPIGDKKLRNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISGKSQP 1397
            .::....|.|..:...::....||.:.||.....:|                  |:.|:    :|
Mouse   567 GLHDLVDIRDSGVEIKVEPTEPEPGMSGAEIVAGVG------------------PVPSM----EP 609

  Fly  1398 SEGRSLEQDVKLGEPQEATSSAVELENVGFSDLLGGLGEGDDDDLLKSLTSEMGDDF-------N 1455
            .|.||.:.|      :|..|||.  .::|.:|  |..|:||:..|....|....:..       |
Mouse   610 PELRSQDSD------EEPRSSAA--GDIGEAD--GSSGKGDERPLSAVKTEASPESMLSPSHGSN 664

  Fly  1456 ILEYADPELDVNVLNSLDFDDNEK 1479
            ::|  || |:....:..:..|:.|
Mouse   665 LIE--DP-LEAETQHKFEMSDSLK 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	21/139 (15%)
		HMG	1173..1231	CDD:197700	6/58 (10%)
Brd8	NP_001348065.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..273		20/111 (18%)
		Atrophin-1	<176..356	CDD:331285	29/179 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..547		9/82 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..745		31/137 (23%)
		Bromo_brd8_like	782..885	CDD:99939
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	900..922
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900