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Protein Alignment Lpt and NSD2

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens

Alignment Length:	750	Identity:	140/750 - (18%)
Similarity:	212/750 - (28%)	Gaps:	320/750 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 CLSCSSLGDLSKLIMC-STCGDHFHSTCIGLANLPDTRSGWNCARCT----KCQICRQQDSNDTK 265
            |..|...|   .|::| ..|...||..|:||:..|:.|  :.|:.|.    .|.:|: :...|.|
Human   670 CQLCEKPG---SLLLCEGPCCGAFHLACLGLSRRPEGR--FTCSECASGIHSCFVCK-ESKTDVK 728

  Fly   266 YVKCEQCQKTYHASCLRPV-ISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQ 329
            .....||.|.||.:|::.. ::.....|::| ....|..|.:..|.....|:  .....|..|..
Human   729 RCVVTQCGKFYHEACVKKYPLTVFESRGFRC-PLHSCVSCHASNPSNPRPSK--GKMMRCVRCPV 790

  Fly   330 QRNKGFSC------------PICQKAYRAAS---HKEMVKCSWCNKFVHS-----TCDEEADLTA 374
            ..:.|.:|            .||...:.|..   |...|..|||  ||.|     .|.|... .|
Human   791 AYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWC--FVCSKGGSLLCCESCP-AA 852

  Fly   375 YHKK--KEQNPDYDYVCPNCKSN------------------------------------------ 395
            :|..  ..:.||..:.|.:|::.
Human   853 FHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGE 917

  Fly   396 -----------------------SSGPGSSQQTIDSI------VLSAMDSSSEQLSL-------- 423
                                   ....||..|.:..|      .|...::...::.|
Human   918 FPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQ 982

  Fly   424 ---------KEIELDPLEGKP---TMDPSSDELHKL--------PTGKKKVCLTSVR-------- 460
                     |.|:::...||.   |.|.|  |:.|.        |.|....||..:.
Human   983 ESERKPPPYKHIKVNKPYGKVQIYTADIS--EIPKCNCKPTDENPCGFDSECLNRMLMFECHPQV 1045

  Fly   461 GRSGKFVLHRMGVMSQINKKR--STRGKGRQLAL---------------PTISSDRCLSR---SM 505
            ..:|:|..::.....|..:.:  .|.|||..|..               ..|..:.|::|   :.
Human  1046 CPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAH 1110

  Fly   506 ETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVK------- 563
            |.|:|  ...:|...:|:.|.|       |..|..|..:..:|       .|.|..:|
Human  1111 ENDIT--HFYMLTIDKDRIIDA-------GPKGNYSRFMNHSC-------QPNCETLKWTVNGDT 1159

  Fly   564 ----------PSRGILQKGWRCLDC-----TVCEGCGKKN------------------------- 588
                      |:...|...:. |||     |||. ||..|
Human  1160 RVGLFAVCDIPAGTELTFNYN-LDCLGNEKTVCR-CGASNCSGFLGDRPKTSTTLSSEEKGKKTK 1222

  Fly   589 ------------------------DEARLLLCDE--CDISYHIYCVNPPLETVPTGNWKCSFCTL 627
                                    |..:|:|||.  |..:||:.|:.  |...|.|.|:|.: ..
Human  1223 KKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLG--LGKRPFGKWECPW-HH 1284

  Fly   628 CQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQL 692
            |..||:                   .|.|.|.:|..|:           |:
Human  1285 CDVCGK-------------------PSTSFCHLCPNSF-----------CK-------------- 1305

  Fly   693 TIDHYDNNVYKC------FKCR-----CSTRSTNS 716
              :|.|...:.|      :.|.     .|.|||.:
Human  1306 --EHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKT 1338

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.