DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and NSD2

DIOPT Version :10

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:NP_001427822.1 Gene:NSD2 / 7468 HGNCID:12766 Length:1398 Species:Homo sapiens


Alignment Length:750 Identity:140/750 - (18%)
Similarity:212/750 - (28%) Gaps:320/750 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 CLSCSSLGDLSKLIMC-STCGDHFHSTCIGLANLPDTRSGWNCARCT----KCQICRQQDSNDTK 265
            |..|...|   .|::| ..|...||..|:||:..|:.|  :.|:.|.    .|.:|: :...|.|
Human   703 CQLCEKPG---SLLLCEGPCCGAFHLACLGLSRRPEGR--FTCSECASGIHSCFVCK-ESKTDVK 761

  Fly   266 YVKCEQCQKTYHASCLRPV-ISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQ 329
            .....||.|.||.:|::.. ::.....|::| ....|..|.:..|.....|:  .....|..|..
Human   762 RCVVTQCGKFYHEACVKKYPLTVFESRGFRC-PLHSCVSCHASNPSNPRPSK--GKMMRCVRCPV 823

  Fly   330 QRNKGFSC------------PICQKAYRAAS---HKEMVKCSWCNKFVHS-----TCDEEADLTA 374
            ..:.|.:|            .||...:.|..   |...|..|||  ||.|     .|.|... .|
Human   824 AYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWC--FVCSKGGSLLCCESCP-AA 885

  Fly   375 YHKK--KEQNPDYDYVCPNCKSN------------------------------------------ 395
            :|..  ..:.||..:.|.:|::.                                          
Human   886 FHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGE 950

  Fly   396 -----------------------SSGPGSSQQTIDSI------VLSAMDSSSEQLSL-------- 423
                                   ....||..|.:..|      .|...::...::.|        
Human   951 FPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQ 1015

  Fly   424 ---------KEIELDPLEGKP---TMDPSSDELHKL--------PTGKKKVCLTSVR-------- 460
                     |.|:::...||.   |.|.|  |:.|.        |.|....||..:.        
Human  1016 ESERKPPPYKHIKVNKPYGKVQIYTADIS--EIPKCNCKPTDENPCGFDSECLNRMLMFECHPQV 1078

  Fly   461 GRSGKFVLHRMGVMSQINKKR--STRGKGRQLAL---------------PTISSDRCLSR---SM 505
            ..:|:|..::.....|..:.:  .|.|||..|..               ..|..:.|::|   :.
Human  1079 CPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAH 1143

  Fly   506 ETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVK------- 563
            |.|:|  ...:|...:|:.|.|       |..|..|..:..:|       .|.|..:|       
Human  1144 ENDIT--HFYMLTIDKDRIIDA-------GPKGNYSRFMNHSC-------QPNCETLKWTVNGDT 1192

  Fly   564 ----------PSRGILQKGWRCLDC-----TVCEGCGKKN------------------------- 588
                      |:...|...:. |||     |||. ||..|                         
Human  1193 RVGLFAVCDIPAGTELTFNYN-LDCLGNEKTVCR-CGASNCSGFLGDRPKTSTTLSSEEKGKKTK 1255

  Fly   589 ------------------------DEARLLLCDE--CDISYHIYCVNPPLETVPTGNWKCSFCTL 627
                                    |..:|:|||.  |..:||:.|:.  |...|.|.|:|.: ..
Human  1256 KKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLG--LGKRPFGKWECPW-HH 1317

  Fly   628 CQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQL 692
            |..||:                   .|.|.|.:|..|:           |:              
Human  1318 CDVCGK-------------------PSTSFCHLCPNSF-----------CK-------------- 1338

  Fly   693 TIDHYDNNVYKC------FKCR-----CSTRSTNS 716
              :|.|...:.|      :.|.     .|.|||.:
Human  1339 --EHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKT 1371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984 14/44 (32%)
PHD2_KMT2C_like 252..298 CDD:276985 12/46 (26%)
PHD_SF 337..392 CDD:473978 19/76 (25%)
PHD4_KMT2C_like 530..578 CDD:276987 10/64 (16%)
PHD5_KMT2C_like 580..625 CDD:276988 19/95 (20%)
PHD6_KMT2C_like 657..707 CDD:276989 7/55 (13%)
NHP6B 1101..>1237 CDD:227935
HMG_KMT2C-like 1157..1223 CDD:438813
NSD2NP_001427822.1 None
Blue background indicates that the domain is not in the aligned region.

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