DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and Kmt2e

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:NP_081260.1 Gene:Kmt2e / 69188 MGIID:1924825 Length:1868 Species:Mus musculus


Alignment Length:1301 Identity:237/1301 - (18%)
Similarity:381/1301 - (29%) Gaps:543/1301 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   610 PPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSS------------CPVCK 662
            ||....|:|        |..|     .|...|...|..|..|.|:.|:            | :|.
Mouse    74 PPASPPPSG--------LISK-----NEVGIFTTPNFDETSSATTISTSEDGSYGTDVTRC-ICG 124

  Fly   663 VSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRCSTRSTNSLADAKFGNEDS 727
            .::.:|.||. |:.|.:|.|..|..::.|...|     .|.|.  ||..||.          :..
Mouse   125 FTHDDGYMIC-CDKCSVWQHIDCMGIDRQHIPD-----TYLCE--RCQPRSL----------DKE 171

  Fly   728 LAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMPESAPEAL-HWIDGVCLSESGLGMIK 791
            .|:..|..|   ....|.|.:..::||.|         :|.....|. |....:.|:.|.:..: 
Mouse   172 RAVLLQRRK---RENMSDGDTSATESGDE---------VPVELYTAFQHTPTSITLTASRVPKV- 223

  Fly   792 SLSTEIKRKR---------KMRQAL--GNGKDGQLEAAAEEALEKYKD--GMVWDGTENAIPEGF 843
               |:.:||:         |.::|.  |:.|..:::.:|.| ::...|  ..||:....|..:.:
Mouse   224 ---TDKRRKKSGEKEQNFSKCKKAFREGSRKSSRVKGSAPE-IDPSSDSSNFVWETKIKAWMDRY 284

  Fly   844 TISINDEGVNILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMT------MDKKKK 902
            ..:.|::....::::.||..|:||.|..|   :.:.|....|.     |||..      :.|.||
Mouse   285 EEANNNQYSEGVQREAQRLAQRLGSGNDS---KDMNKSELSTN-----NSLFRPPVESHIQKNKK 341

  Fly   903 IIRKKQ---KNKLIEAY--PVYLQEA------FFGKPL--------LEGGEL-VMADTDSSD--- 944
            |::..:   .:.||..|  ...|:|.      ||.:|.        ..|.|: |.|.|..::   
Mouse   342 ILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARF 406

  Fly   945 -------------EID-----------------ASMKVYFTRPEGKSPANQDTLAVNKSPAKTVK 979
                         ||:                 ..:.:.|....|......|...:.::|...|.
Mouse   407 IRRSCTPNAEVRHEIEEGTIHLYIYSIQSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVL 471

  Fly   980 KVKAELKTEN-KTVFIQQMPMG-----------IQNKNGTTPVSNV-------------FDPLQA 1019
            |..:| .||| .:.:..:...|           |||:|.|......             ..||:.
Mouse   472 KRSSE-STENINSGYETRRKKGKKEKDTSKEKDIQNQNMTLDCEGTNNKIRSPETKQRKLSPLRL 535

  Fly  1020 EISNTVFANRHP-----------------------------------------LDALASPNVPEL 1043
            .:||    |:.|                                         |.|.|.....|.
Mouse   536 SVSN----NQEPDFIDDMEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREK 596

  Fly  1044 DMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPA-------- 1100
            ....::..:.:|:...||..:...|:.|:.:|..|:.:|            |.:.||        
Mouse   597 RREQALERISTAKTEVKPECKESQVIADAEVVQEQVKEE------------TAIKPAAAKVNRTK 649

  Fly  1101 QQLQF---RQQAPQNANKQNMQTIMSQV--------VLQTEKRPEEEQKVVEPVTET-------- 1146
            |:..|   |....|...:....::.|.:        ||..:...|.....:||.|||        
Mouse   650 QRKSFSRSRTHIGQQRRRHRTVSMCSDIPPSSPDIEVLSQQNEIENTVLAIEPETETAVAEIIPE 714

  Fly  1147 --------------------LNAGTQKTAEKMRKDEDL-----------------------GLMA 1168
                                :|....:..||..|..|.                       ||  
Mouse   715 AEVPALNKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDSLSERPLRITTDPEVLATQLNSLPGL-- 777

  Fly  1169 TISAVLYANTEH------PNL------KELFPIWNDRCKQ-------------ILKRWRSLCNEK 1208
            |.|..:|:..:|      |.|      ||.....:..||:             ||.|:.|.|.|:
Mouse   778 TYSPHVYSTPKHYIRFTSPFLSEKKRRKETTENISGSCKKRWLKQALEEENSTILHRYHSPCQER 842

  Fly  1209 ----------KAPFLQ----KAKDNRSALRQRR---------EQNKIP----------------- 1233
                      |:|.|.    ...|..:.|::||         .::..|                 
Mouse   843 SRSPTVNGENKSPLLLSDSCSLPDLTTPLKKRRLYQLLDTAYSESSTPTPSPYATPTHTDITPTD 907

  Fly  1234 ----MPPKPQKQEEMGRVWKQP----------------------------PKLKE--------DQ 1258
                .||:.:..:|..|...:|                            |::|.        |:
Mouse   908 PAFATPPRIKSDDETYRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRCTYNQEGYDR 972

  Fly  1259 PNMFVTY----NGNAYDMG-------NYVGGSAQAASNNPNPHHVMPNVND-----NLVIKATMQ 1307
            |:..:|.    |.|..::|       .|....::...|.|.|.. ..:|:|     :.|..|.:|
Mouse   973 PSNMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRPCPGE-KESVSDLQLGLDAVEPAALQ 1036

  Fly  1308 ------------------------------------RTQVHTTAASTLKMTTVDNRLELNTAVYG 1336
                                                ||.|:.:..|.|:..|..::||..    |
Mouse  1037 KSMETPAHDRTEPSNQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLTPSHQLETG----G 1097

  Fly  1337 TEPIGDKKLRNLLQKNSTEPMLMGA------------------NSDLFLGNDVMRLGMMQNTP-- 1381
            ...:.:.|.  |:|::.|..|.:||                  |.:|..|:..     .||.|  
Mouse  1098 GFRVSESKC--LIQQDDTRGMFLGAAVFCTSEDGLASGFGRTVNDNLIDGSCT-----PQNPPQK 1155

  Fly  1382 --------------------ITQNNPMLSIS------------GKSQPSE-GRSLEQDVKLGEPQ 1413
                                ..:|..::|:|            |....|| |...|....|..|.
Mouse  1156 KKVSLLEYRKRQREARKSGSKPENFALISVSPHPSGSLSSSGDGCVHSSENGEQAENQASLPLPP 1220

  Fly  1414 EATSSAVELENVGFSDLLGGLGEGDDDDLLKSLTSEMGD------DFNILEYADPELDVNVLNSL 1472
            .|.::|....                  ...|.:||.|.      |.|..|..|||:......|:
Mouse  1221 PAAAAAATAA------------------AAYSASSEEGSSNCPVKDANSSEKKDPEVQWTASTSV 1267

  Fly  1473 D 1473
            :
Mouse  1268 E 1268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984
PHD2_KMT2C_like 252..298 CDD:276985
PHD_SF 337..392 CDD:304600
PHD4_KMT2C_like 530..578 CDD:276987
PHD5_KMT2C_like 580..625 CDD:276988 4/14 (29%)
PHD6_KMT2C_like 657..707 CDD:276989 14/61 (23%)
NHP6B 1101..>1237 CDD:227935 45/266 (17%)
HMG 1173..1231 CDD:197700 21/105 (20%)
Kmt2eNP_081260.1 HCFC1-binding motif (HBM). /evidence=ECO:0000250|UniProtKB:Q8IZD2 63..66
PHD_MLL5 120..163 CDD:277025 14/51 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..197 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 217..268 10/55 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 308..329 8/28 (29%)
SET_KMT2E 323..451 CDD:380959 24/132 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 472..504 6/32 (19%)
Smc 483..>716 CDD:224117 40/248 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..682 5/35 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 884..924 4/39 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1038..1068 0/29 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222 10/56 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1236..1315 10/33 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1334..1565
Herpes_BLLF1 <1350..1609 CDD:282904
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1585..1842
PRK03427 <1749..>1857 CDD:235124
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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