DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpt and Pbrm1

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_001074720.1	Gene:	Pbrm1 / 66923	MGIID:	1923998	Length:	1704	Species:	Mus musculus

Alignment Length:	955	Identity:	175/955 - (18%)
Similarity:	304/955 - (31%)	Gaps:	344/955 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   784 ESGLGMIKSLSTE---IKRKRKMR--QALG--------NGKDGQLEAAAEEALEKYKDG------ 829
            |.|..||.|.:::   .||||...  :.||        |.:..:::......||..:.|
Mouse   494 EDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKILFNVVLEAREPGSGRRLC 558

  Fly   830 ---MVWDGTENAIPEGFTISI-------------ND-----EGVNILRKKRQRNLQKLGIGGFSV 873
               || ..::...|:.:.|.:             ||     ||:....|...||.:.....|..|
Mouse   559 DLFMV-KPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMMEDMKLMFRNARHYNEEGSQV 622

  Fly   874 RN-----RGLKKDSEETTAV-----DQINSLMTMDKKKKIIRKKQK---------NKLIEAYPVY 919
            .|     ..|.||..:....     |..:..:.:.:|..:..||.|         |::.||...|
Mouse   623 YNDAHILEKLLKDKRKELGPLPDDDDMASPKLKLSRKSGVSPKKSKYMTPMQQKLNEVYEAVKNY 687

  Fly   920 -------LQEAFFGKPLLEGGEL-------------------VMADTDSSDEIDASMKVYF---- 954
                   |...|...|  ...||                   :||  :...:||:.::.:.
Mouse   688 TDKRGRRLSAIFLRLP--SRSELPDYYLTIKKPMDMEKIRSHMMA--NKYQDIDSMVEDFVMMFN 748

  Fly   955 ---TRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTE--NKTVFIQQMPMGIQNKNGTTPVSNVF 1014
               |..|.:|...:|.|.::|...:|.:.::.:..:.  |.|:.||::            :.|:|
Mouse   749 NACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQEL------------IHNLF 801

  Fly  1015 DPLQAEISNTVFANRHPLDALA--------SPNVPELDMANSVSTVPS-------------AEVI 1058
               .:.:|:.....|...|:||        |||.|.|........|.|             .||:
Mouse   802 ---VSVMSHQDDEGRCYSDSLAEIPAVDPNSPNKPPLTFDIIRKNVESNRYRRLDLFQEHMFEVL 863

  Fly  1059 EKPMRESPAVLVDSFMVPNQLPQEQKF---HNQLYLGGNTLVNPAQQLQFRQQAPQN-ANKQNMQ 1119
            |:..|.:   ..||.:..:.:..:|.|   .::|...|..|::||  |.:..:...| ..|:..:
Mouse   864 ERARRMN---RTDSEIYEDAVELQQFFIRIRDELCKNGEILLSPA--LSYTTKHLHNDVEKEKKE 923

  Fly  1120 TIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGL---MATISAVLYANTEHP 1181
            .:..::  :.:|...||:|.....:|..:..|..:.......:|...   |..:...:|......
Mouse   924 KLPKEI--EEDKLKREEEKREAEKSEDSSGTTGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEA 986

  Fly  1182 NLKE----LFPIWNDRCKQILKRWRSLC-----NE----KKAPFLQKAKDNRSALRQRREQNKIP 1233
            ||:.    :..:|.|...:   :|...|     ||    ....||:|      .:.:....||:|
Mouse   987 NLQPHIVCIERLWEDSAGE---KWLYGCWFYRPNETFHLATRKFLEK------EVFKSDYYNKVP 1042

  Fly  1234 MP------------------PKPQKQEEMG----------------RVWKQP------------- 1251
            :.                  |:..:.|::.                ::|..|
Mouse  1043 VSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPL 1107

  Fly  1252 PKLK-----------EDQPNMFVTYNGNAYDMGNYVGGS----AQAASNNPNPHH--------VM 1293
            |.::           :|:.|...:.:..|.|..|.....    .:.::..|..|:        :.
Mouse  1108 PVVRVASVFANADKGDDEKNTDNSDDNRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLRYNDMW 1172

  Fly  1294 PNVNDNLVIKA-TMQRTQVHTTAASTLKMTTVDNRLE----LNTAVYGTEPIGDKKLRNLLQKNS 1353
            ..|.|.:.||: .:.|.:|              .|:|    .:.|.|...||       .:....
Mouse  1173 LKVGDCVFIKSHGLVRPRV--------------GRIEKVWVRDGAAYFYGPI-------FIHPEE 1216

  Fly  1354 T--EPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISGK-----------SQPS------- 1398
            |  ||..|....::||.|            :.:..||..|.||           .:|:
Mouse  1217 TEHEPTKMFYKKEVFLSN------------LEETCPMSCILGKCAVLSFKDFLSCRPTEIPENDI 1269

  Fly  1399 ---EGRSLEQDVKL------------------------------GEPQEATSSAVELENVGFSDL 1430
               |.|..|.|.::                              .||.......::|....|::|
Mouse  1270 LLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIIPQKEPSPLLEKKIQLLEAKFAEL 1334

  Fly  1431 LGGLGEGDDDDLLKSLTSEMG-DDFNILEYAD-PELDVNVLNSLD 1473
                 ||.|||:     .||| :|..::|... |:|...:.|.||
Mouse  1335 -----EGGDDDI-----EEMGEEDSEVIEAPSLPQLQTPLANELD 1369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	26/170 (15%)
		HMG	1173..1231	CDD:197700	12/70 (17%)
Pbrm1	NP_001074720.1	Bromo_polybromo_I	44..156	CDD:99954
		Bromo_polybromo_II	182..284	CDD:99948
		Bromo_polybromo_III	383..484	CDD:99951
		Bromo_polybromo_IV	534..637	CDD:99949	20/103 (19%)
		Bromo_polybromo_V	673..777	CDD:99946	20/107 (19%)
		Bromo_polybromo_VI	790..897	CDD:99956	26/124 (21%)
		BAH_polybromo	972..1089	CDD:240068	18/125 (14%)
		BAH_polybromo	1170..1288	CDD:240068	29/150 (19%)
		HMG-box	1395..1459	CDD:238037
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900