DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and KMT2C

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_005250082.1 Gene:KMT2C / 58508 HGNCID:13726 Length:4983 Species:Homo sapiens


Alignment Length:1744 Identity:446/1744 - (25%)
Similarity:662/1744 - (37%) Gaps:584/1744 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 STNVVVSMEEKAVADDLPYFPEKFPGKVCCLCNLGEKSALGQGEILQLK-APA--------PAEI 57
            |.|.:||:..:|          |...::|..|..||||:||||::.|.: .|.        |:..
Human   117 SANSLVSVGVEA----------KISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNK 171

  Fly    58 KD----------KYPTDRLRED-GSRLLYGPKQ-------------AASSSGDCHYELDKIGQPD 98
            ||          |......|:. |.|....|:|             :...:|....||..:|.||
Human   172 KDIDDNSNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPD 236

  Fly    99 VVH-PAEFLDEGFVYVHRMCIMWSLRKSQISD-----ADGAYFATHFAEFLEQKCNFCGRYGASI 157
            .:. .|.|...|..:.|..|:.|||...|:.:     .|.|..:..     .::|.||...||:|
Human   237 AIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLLVNVDKAVVSGS-----TERCAFCKHLGATI 296

  Fly   158 N-CKMNCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLGDLSKLIMC 221
            . |:..|.|::|:||||.||.........:.|.||:.|.|. .|..:..|..|.|.|||.....|
Human   297 KCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPE-RSKEDANCAVCDSPGDLLDQFFC 360

  Fly   222 STCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYHASCLRPVIS 286
            :|||.|:|..|:.:|..|..|:||.|..|..||.|: |...|:|.:.|:.|.|.||..||:||:.
Human   361 TTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCK-QSGEDSKMLVCDTCDKGYHTFCLQPVMK 424

  Fly   287 AIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQKAYRAASHKE 351
            ::|..||||..||:|.:||:|     |||:||.:..|||:||||::.  .||.|.|.|.....|:
Human   425 SVPTNGWKCKNCRICIECGTR-----SSSQWHHNCLICDNCYQQQDN--LCPFCGKCYHPELQKD 482

  Fly   352 MVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCK----------------------- 393
            |:.|:.|.::||..||:..|.....:.||     :|:|..||                       
Human   483 MLHCNMCKRWVHLECDKPTDHELDTQLKE-----EYICMYCKHLGAEMDRLQPGEEVEIAELTTD 542

  Fly   394 --------------------------SNSSGPG-------------------------------S 401
                                      ...|.||                               |
Human   543 YNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVS 607

  Fly   402 SQQTIDS-----------------------------------------IVLSAMDSSSEQLSLKE 425
            ||.|:::                                         :|...:....|||.|.|
Human   608 SQHTVNTELEKQISNEVDSEDLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLE 672

  Fly   426 -----------------------------------IELDP--------LEGK------------- 434
                                               |.|.|        |:|:             
Human   673 EPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERLQGEKEQKENSELSTGL 737

  Fly   435 ------PTMD---------------------------------------------PSSDELHKLP 448
                  ||::                                             ||.|.||..|
Human   738 MDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYP 802

  Fly   449 TG----------------------------KKKVCLTSVRGRSGKFVLH---------------- 469
            :.                            |:|......|.:.|.:..|                
Human   803 SALSSSAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGR 867

  Fly   470 ----------------RMGVMSQINKKRSTR--------GKGRQ--------LALPTISSDRCLS 502
                            ::|..|....||..|        |:||.        :.||.:|:....|
Human   868 EIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISS 932

  Fly   503 RSMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRG 567
            ...:.:.:....::|.|:.|||...||:||:|||.|..::..::.|:||||||||||..:|.::.
Human   933 NKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKV 997

  Fly   568 ILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCG 632
            :|.||||||:|||||.|||..|..||||||:||||||.||::|||:|||.|.|||.:|..|:.||
Human   998 VLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCG 1062

  Fly   633 RNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHY 697
            ...........:|..:|..|.|.||||||..:|...::|:||..|:.|.|..|.::|.:..:::.
Human  1063 ATSAGLRCEWQNNYTQCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENV 1127

  Fly   698 DNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFD---SKSGAERNH 759
            .:..:.|..||                            |:  :.||:.||.|   |...|:   
Human  1128 ADIGFDCSMCR----------------------------PY--MPASNVPSSDCCESSLVAQ--- 1159

  Fly   760 PTLSGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQAL----------------- 807
              :...:.|..|...:..|||||:|||:..::||:..:.|:::.:..|                 
Human  1160 --IVTKVKELDPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPP 1222

  Fly   808 ----GNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNILR--KKRQRNLQKL 866
                .:.:||:::.:.|..|      |..||...:.||...:....:||....  |||:|...:.
Human  1223 DIQSEHSRDGEMDDSREGEL------MDCDGKSESSPEREAVDDETKGVEGTDGVKKRKRKPYRP 1281

  Fly   867 GIGGFSVRNRG-----------LKKDSEET------------------TAVDQINSLMTMDKKKK 902
            |||||.||.|.           ::|||..:                  |.||:..|:....:|.|
Human  1282 GIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDGWSEQLPDTLVDESVSVTESTEKIK 1346

  Fly   903 IIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEG--KSPANQ 965
            ...:|:||||.|.:|.|||||||||.||:.........|:..| |.:..:|.|....  ..|:..
Human  1347 KRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQSKISLDNLSE-DGAQLLYKTNMNTGFLDPSLD 1410

  Fly   966 DTLAVNKSPAKT---------VKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEI 1021
            ..|:.:.:|.|:         :..:...|.|::..       :||           :.|.|...:
Human  1411 PLLSSSSAPTKSGTHGPADDPLADISEVLNTDDDI-------LGI-----------ISDDLAKSV 1457

  Fly  1022 SNT--------VFANRHPLD---------ALASPNV-----------------PELD-------M 1045
            .::        |.::..|.|         :|..|||                 ||||       :
Human  1458 DHSGLDLCTFQVESSPFPFDIGPVTDDPSSLPQPNVNQSSRPLSEEQLDGILSPELDKMVTDGAI 1522

  Fly  1046 ANSVSTVPSAEVIEKPMRE-SPAVLVDSFMVPNQLPQEQ------KFHNQLYLGGNTLVN----- 1098
            ...:..:|  |:..|.:.: ..|||..:...|..|||..      ..|||.......|:|     
Human  1523 LGKLYKIP--ELGGKDVEDLFTAVLSPANTQPTPLPQPPPPTQLLPIHNQDAFSRMPLMNGLIGS 1585

  Fly  1099 ----------PAQQL----QFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNA 1149
                      |...|    ...|.:..:|..:|  :..:.:..............||...:|: :
Human  1586 SPHLPHNSLPPGSGLGTFSAIAQSSYPDARDKN--SAFNPMASDPNNSWTSSAPTVEGENDTM-S 1647

  Fly  1150 GTQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQ 1214
            ..|::..|..|:|.||.|||::.|||.|...|||||.||.|..|.|||.|.||...::::||::|
Human  1648 NAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQ 1712

  Fly  1215 KAKDNRSALR----------QRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQ 1258
            ||:|||:|||          .:|:|.:..:.|..:...|:   :|.|.|.:|.:
Human  1713 KARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSEL---FKDPLKQRESE 1763

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135 26/87 (30%)
PHD1_KMT2C_like 205..250 CDD:276984 19/44 (43%)
PHD2_KMT2C_like 252..298 CDD:276985 20/45 (44%)
PHD_SF 337..392 CDD:304600 18/54 (33%)
PHD4_KMT2C_like 530..578 CDD:276987 25/47 (53%)
PHD5_KMT2C_like 580..625 CDD:276988 31/44 (70%)
PHD6_KMT2C_like 657..707 CDD:276989 15/49 (31%)
NHP6B 1101..>1237 CDD:227935 48/149 (32%)
HMG 1173..1231 CDD:197700 32/67 (48%)
KMT2CXP_005250082.1 ePHD1_KMT2C 248..331 CDD:277166 26/87 (30%)
PHD1_KMT2C_like 344..389 CDD:276984 19/44 (43%)
PHD2_KMT2C 391..436 CDD:277069 20/45 (44%)
PHD3_KMT2C 467..518 CDD:276986 18/55 (33%)
PHD4_KMT2C 953..1009 CDD:277071 29/55 (53%)
PHD5_KMT2C_like 1010..1056 CDD:276988 31/45 (69%)
RanBP2-type Zn finger 1085..1107 CDD:275375 10/21 (48%)
PHD6_KMT2C 1087..1137 CDD:277073 15/49 (31%)
HMG-box 1671..1722 CDD:294061 28/50 (56%)
DUF2962 1709..>1792 CDD:288077 18/58 (31%)
SYCE1 <3198..3287 CDD:291886
ePHD2_KMT2C 4474..4578 CDD:277167
FYRN 4624..4674 CDD:283589
FYRC 4680..4761 CDD:283590
SET <4797..4983 CDD:225491
SET 4844..4965 CDD:214614
PostSET 4967..4983 CDD:214703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 161 1.000 Domainoid score I4031
eggNOG 1 0.900 - - E2759_KOG4443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 630 1.000 Inparanoid score I853
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D39671at33208
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102575
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X2220
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.890

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