DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Brd4

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_001273559.1	Gene:	Brd4 / 57261	MGIID:	1888520	Length:	1401	Species:	Mus musculus

Alignment Length:	1078	Identity:	176/1078 - (16%)
Similarity:	319/1078 - (29%)	Gaps:	376/1078 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 DLTAYHKKKEQN---------PDYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSEQLSLKEI 426
            |:....|:.|.|         .|::.:..||...:. ||      |.|||  |..:.|:|.|::|
Mouse   106 DMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK-PG------DDIVL--MAEALEKLFLQKI 161

  Fly   427 ELDPLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQLA 491
                              ::|||.:.::.:...:||               .:.|...|:..:..
Mouse   162 ------------------NELPTEETEIMIVQAKGR---------------GRGRKETGRAAKPG 193

  Fly   492 LPTISSDRCLSRSMETD-------------------LTSDKKLLLCSARDKFIQAQDICVMCGSL 537
            :.|:.:....|.|.:|.                   :|.|           .|....:..|....
Mouse   194 VSTVPNTTQASTSPQTQTPQQNPPPPVQATTHPFPAVTPD-----------LIAQPPVMTMVPPQ 247

  Fly   538 GIESDSVM--------ITCAQCGQCYHPYCA----GVKPSRGILQKGWRCLDCTV---------- 580
            .:::.|.:        ....|..|.:.|..|    .||..:|:.:|.......|:
Mouse   248 PLQTPSPVPPQPPPPPAPVPQPVQSHPPIIATTPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLA 312

  Fly   581 ----CEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEF 641
                ....|.:.:.:|              .|.||.:.||...             ::|..:...
Mouse   313 PEPKTAKLGPRRESSR--------------PVKPPKKDVPDSQ-------------QHPGPEKSS 350

  Fly   642 GDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELW------------AHFHCDSVNAQLTI 694
            ..|..|:|  |:.     :.|      ||..:......|            .|.:||.:...:.:
Mouse   351 KISEQLKC--CSG-----ILK------EMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDM 402

  Fly   695 ----DHYDNNVYK---------------CFKCR-------CSTRSTNSLADAKFGNEDSLAITPQ 733
                ...::..|:               |:|..       ...|....:.:.:|..     :..:
Mouse   403 STIKSKLESREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAK-----MPDE 462

  Fly   734 GSKPFVHITASSGP----------SFDSKSGAERNHPTLSGDMPESAPEALHWIDG--VCLSESG 786
            ..:|.|.:::.:.|          |.||.|.:..:..:.:.|..|...:.|..:..  ..:.|..
Mouse   463 PEEPVVTVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQL 527

  Fly   787 LGMIKSLSTEIKRKRKMRQALGNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEG 851
            ..:.:....:.|:|.|.::.....|..:.|...|....|.|:          :|...|...|...
Mouse   528 AALSQPQQNKPKKKEKDKKEKKKEKHKKKEEVEENKKSKTKE----------LPPKKTKKNNSSN 582

  Fly   852 VNILRK----------------------------KRQRNL-------QKLG--IGGFSVRNRGLK 879
            .|:.:|                            |||.:|       :|||  :.....|...||
Mouse   583 SNVSKKEPVPTKTKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLK 647

  Fly   880 KDSEETTAVD----------QINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEG-- 932
            ..:.:...:|          ::...:|...:||  ||.|..|:         :...|...::|
Mouse   648 NSNPDEIEIDFETLKPSTLRELERYVTSCLRKK--RKPQAEKV---------DVIAGSSKMKGFS 701

  Fly   933 ---GELVMADTDSSDEIDA-------SMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKT 987
               .|.. :::.|||..|:       |.|...|..:.|...:.....:..:||...
Mouse   702 SSESEST-SESSSSDSEDSETEMAPKSKKKGHTGRDQKKHHHHHHPQMQPAPAPVP--------- 756

  Fly   988 ENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTV 1052
                   ||.|...|......|      |.|.:        :.|......|::|:.......|:.
Mouse   757 -------QQPPPPPQQPPPPPP------PQQQQ--------QQPPPPPPPPSMPQQTAPAMKSSP 800

  Fly  1053 PSAEVIEKPMRE---------------SPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQ 1102
            |.....:.|:.|               .|.:.:....:|..|||..:.....:|..:.:|:|
Mouse   801 PPFITAQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSP--- 862

  Fly  1103 LQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLM 1167
                 .|..||            :.|...||......:.|......|.:...|:.....:.  .|
Mouse   863 -----PALHNA------------LPQQPSRPSNRAAALPPKPTRPPAVSPALAQPPLLPQP--PM 908

  Fly  1168 ATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAK-----------DNRS 1221
            |....||..:.|.|    ..|:.:.:.:..|::.:.:  :...|.|...|           ....
Mouse   909 AQPPQVLLEDEEPP----APPLTSMQMQLYLQQLQKV--QPPTPLLPSVKVQSQPPPPLPPPPHP 967

  Fly  1222 ALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQP 1259
            :::|::.|.:.|.||.||         .|||..::.||
Mouse   968 SVQQQQLQPQPPPPPPPQ---------PQPPPQQQHQP 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600	5/29 (17%)
		PHD4_KMT2C_like	530..578	CDD:276987	10/59 (17%)
		PHD5_KMT2C_like	580..625	CDD:276988	7/58 (12%)
		PHD6_KMT2C_like	657..707	CDD:276989	9/80 (11%)
		NHP6B	1101..>1237	CDD:227935	24/146 (16%)
		HMG	1173..1231	CDD:197700	11/68 (16%)
Brd4	NP_001273559.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Bromo_Brdt_I_like	58..164	CDD:99929	18/84 (21%)
		Bromo_Brdt_II_like	355..456	CDD:99930	14/113 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..617		24/164 (15%)
		NPS region. /evidence=ECO:0000250	486..505		4/18 (22%)
		BID region. /evidence=ECO:0000250	526..581		11/64 (17%)
		BET	611..675	CDD:407211	11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..1126		73/400 (18%)
		PHA03247	<793..1231	CDD:223021	44/241 (18%)
		C-terminal (CTD) region. /evidence=ECO:0000250	1051..1401
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1378
		TPH	<1267..1308	CDD:404709
		BRD4_CDT	1359..1401	CDD:407248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900