DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and ep300b

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_009297682.1 Gene:ep300b / 565612 ZFINID:ZDB-GENE-080403-15 Length:2646 Species:Danio rerio


Alignment Length:1711 Identity:299/1711 - (17%)
Similarity:529/1711 - (30%) Gaps:580/1711 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 FATHFAEFLEQKCN--------FCGR-----------YGASINCKMNCRQVHHWPCAAAAGCLLI 180
            :.:..||..||:.:        .|||           ||..: |.:. |...::....::....:
Zfish  1125 YCSKLAEVFEQEIDPVMQELGYCCGRKLEFSPQTLCCYGKQL-CTIP-RDAAYFSYQNSSPKYGL 1187

  Fly   181 LESFTVFCTEHLSQVPVICSDNNVECLSCSSLGD--------LSK---------------LIMCS 222
            |.....||.:..:::    ...||      ||||        ::|               |:.|.
Zfish  1188 LADRYHFCEKCFNEI----QGENV------SLGDDPTQPQTSINKDQFQRKKNDTLDPELLLECG 1242

  Fly   223 TCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTK---------------------- 265
            .||...|..|: |.|.....||:.|..|.|       .||.|:                      
Zfish  1243 DCGRKMHQICV-LHNETIWPSGFICDGCLK-------KSNSTRKENKYAAKRLPQTKLGNFLETR 1299

  Fly   266 ---YVK-------CEQCQKTYHASCLRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSH 320
               |:|       .|...:..|.|  ..|:...|  |.|           ||....|..|....:
Zfish  1300 VNDYLKRQNHPESGEVTIRVVHIS--DKVVEVKP--GMK-----------SRFVDSGEMSESFPY 1349

  Fly   321 YTIC----------DSCY---QQRNKGFSCPICQKAYRAASHKEMVKCSWCNKFVHSTCDEEADL 372
            .|..          |.|:   ..:..|..||        ..::..|..|:.:. ||.........
Zfish  1350 RTKALFAFEEIDGTDVCFFGMHVQEYGSDCP--------PPNQRRVYISYLDS-VHFFQPRHLRT 1405

  Fly   373 TAYHK---------KK-------------EQNPDYDYVCPNCKSNSSGPGSSQQ---------TI 406
            ..||:         ||             .:..||.:.|.........|...|:         ..
Zfish  1406 GVYHEILIGYLEYVKKMGFVMGHIWACPPSEGDDYIFHCHPSDQKIPKPKRLQEWYKKMLDKAVT 1470

  Fly   407 DSIVLSAMD----------SSSEQL--------------SLKEIELDPLEGKPTMDPSSDELHKL 447
            :.||....|          :|:::|              |:||:|.:..|.|...:.:|.|....
Zfish  1471 ERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENNTSSESIDA 1535

  Fly   448 PTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKR---------------STRGKGRQL------- 490
            ..|..|    :.:.::.|........:|:.|||:               :|..|.:::       
Zfish  1536 TNGDSK----NAKKKNNKKTSKNKSSLSRANKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRFI 1596

  Fly   491 ------ALPTISSDRCLSRSMETDLTSDKKLLLCSARDKFIQAQDI--------CVMCGSLGIES 541
                  :||.||....|   |..||...:...|..||||.::...:        |::........
Zfish  1597 AGPAANSLPPISDPDTL---MACDLMDGRDAFLTLARDKHLEFSSLRRAKWSSMCMLVELHNQTQ 1658

  Fly   542 DSVMITCAQCGQ----CYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDIS 602
            |..:.||.:|..    .:|                     |||||...         ||..|   
Zfish  1659 DRFVYTCNECKHHVETRFH---------------------CTVCEDYD---------LCITC--- 1690

  Fly   603 YHIYCVNPPLETVPTG-----NWKCSFCTLCQKCGRNPTEKSEFGDSNML-------------EC 649
            |::......:|.:..|     |.:.:..|      :||      |||..|             :|
Zfish  1691 YNVKGHEHKMEKLGLGLDDESNNQAAAST------QNP------GDSRRLSIQRCIQSLVHACQC 1743

  Fly   650 -------PSC---------------TSQSSCPVCKVSYSNGEMI-IQCEHCELWAHFHCDSVNAQ 691
                   |||               .:...||:||      ::| :.|.|.:     ||......
Zfish  1744 RNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICK------QLIALCCYHAK-----HCQETKCP 1797

  Fly   692 ----LTIDH--------YDNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITAS 744
                |.|.|        :.....:..:.|.:|..       :.|........|.|..|......:
Zfish  1798 VPFCLNIKHKLRQQQLQHRLQQAQMLRRRMATMQ-------RVGQPPPCGGGPPGGLPSPGNNGA 1855

  Fly   745 SGPSFDSKSGAERNHPTL---------------SGDMPESAPE--ALHWIDGVCLSESGL-GMIK 791
            :|||..:..|.:...|..               :|.:|..||:  ..|.:........|. ||:.
Zfish  1856 TGPSTPTSVGTQPATPQTPTQLTPNLISLPQPGAGGVPAGAPQQSPQHPVHHQFQQMPGAGGMMN 1920

  Fly   792 SLSTEIKRKRKMRQ------------------ALGNGKDGQLEAAAEEALEKYKDGMVWDGTENA 838
            |...::..::.:.|                  ....||.| |..|....|.. ..|.| ...:..
Zfish  1921 SQQQQMVPQQSLGQVPHPHNQYGPHPTGPSPNTQSQGKPG-LGPATPPQLPS-NPGTV-PMAQQQ 1982

  Fly   839 IPEG-----FTISINDEGVNILRKKR------QRNLQKLGI---------GGFSVRNRGLKKDSE 883
            .|.|     ..|::..:.|...::|.      ||...:.|:         |...|.:.|:.....
Zfish  1983 QPTGPPAAAVEIAMKIQQVADAQRKMAQVQLLQRQAAQAGMMPQHHQQPQGQIGVAHPGIGMVGP 2047

  Fly   884 ETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDA 948
            :..|    :...|...:.::.:::....::.|.|:..|:.   :.:...|::..........::.
Zfish  2048 QGLA----SQAQTSANRVQMEQQQGPQGMMGAGPMQQQQP---QQVAVQGQMPPQMHPQQPRMNP 2105

  Fly   949 SMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNV 1013
            .::....:..|:....|...|:.........:.:.:.:..::....||.|. :.|:|..  :|.|
Zfish  2106 PLQPQQQQWPGQGMPTQQRPAMMSQQGMVSMQPQPQPQQPSQQTQQQQAPQ-MPNRNAL--MSMV 2167

  Fly  1014 FDPLQAEISNTVFANRHP-------LDALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVD 1071
            ...||:.:::...|:..|       |..|.||:.|:           ..:.:...:|.|| :|:.
Zfish  2168 QAGLQSGVASGAAASNLPQGALQQLLRTLRSPSSPQ-----------QQQQVLNILRSSP-LLMA 2220

  Fly  1072 SFMVPNQLPQEQKFHNQLYLGG---------------------NT-----------LVNPAQQLQ 1104
            :|:       :|:.|.  |.||                     ||           .||...||.
Zfish  2221 AFI-------KQRVHK--YKGGTGGPSGPQGGPGPMGGQPVGVNTGVPQPGMHLGQGVNMQSQLL 2276

  Fly  1105 FRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAE-KMRKDEDLGLMA 1168
            .:||:.|....|....:..|.|...:::.:::|:..:...:..:...|:..: :.::.:..|:..
Zfish  2277 SQQQSQQQQQMQQRPLLQQQQVAALQQQQQQQQQQQQQQQQQQHQQQQQQQQHQQQQQQQQGIQG 2341

  Fly  1169 TISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSL----CNEKKAPFLQKAKDNRSALRQRR-- 1227
            ..:    .|..:|:.:||          :::|.:.|    ..:::....|:...|.:|.:|::  
Zfish  2342 QGT----PNMANPHFREL----------VMRRQQQLQFQQQQQQQQQQQQQQMSNHAAFQQQQGY 2392

  Fly  1228 --EQNKIPMPP--------KP-QKQEEMGRVWKQ------PPKLKEDQPNMFVTYNGNAYDMGNY 1275
              :|..:.:||        :| |:|...|...:|      ..:|.:.|..:.:....||...|..
Zfish  2393 MSQQGNMQVPPGGQPLQGVQPGQQQNFPGNPAQQQAAAALQQRLAQQQHQLQMQQQQNAATQGPD 2457

  Fly  1276 VGGSAQAASNNPNPHHVMPNVN--DNLVIKATMQR---TQVHTTAASTLKMTTVDNRLELNTAVY 1335
            :|     ....|.|..:.|.:.  ..|:.:|..||   .|.|.:..|..:.              
Zfish  2458 MG-----PGGGPQPTQLGPGLQSPQALLQQALHQRLFPQQQHLSGTSPAQQ-------------- 2503

  Fly  1336 GTEPIGDKKLRNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISG---KSQP 1397
             ..|:..::     |:.|..|.|.|......|.|.|.   ..|.:|..|:.|..|...   :.||
Zfish  2504 -NNPMSPQQ-----QQISQSPHLQGQQLPSSLSNQVC---SPQPSPRPQSQPPHSSPSPRLQPQP 2559

  Fly  1398 SEGRSLEQDVKLGEP-------------------QEATSSAVEL------ENVGFSDLLG--GLG 1435
            |. ..:....:.|.|                   |:...::.:.      :|...|.|.|  ||.
Zfish  2560 SP-HHISPQTQTGSPHPSHLQQHHSGMAPPPPPHQQPQHNSKDPSGFGADQNAMLSQLSGMAGLH 2623

  Fly  1436 EGDDDDLLKSLTSEMGDDFNI 1456
            ....:|:|.....::|.:.|:
Zfish  2624 GPGANDMLPPSGQDLGINMNL 2644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135 14/74 (19%)
PHD1_KMT2C_like 205..250 CDD:276984 16/67 (24%)
PHD2_KMT2C_like 252..298 CDD:276985 13/77 (17%)
PHD_SF 337..392 CDD:304600 13/76 (17%)
PHD4_KMT2C_like 530..578 CDD:276987 6/59 (10%)
PHD5_KMT2C_like 580..625 CDD:276988 10/49 (20%)
PHD6_KMT2C_like 657..707 CDD:276989 12/62 (19%)
NHP6B 1101..>1237 CDD:227935 24/152 (16%)
HMG 1173..1231 CDD:197700 11/65 (17%)
ep300bXP_009297682.1 zf-TAZ 318..385 CDD:280324
KIX 534..614 CDD:280354
Bromo_cbp_like 1024..1142 CDD:99927 4/16 (25%)
RING_CBP-p300 1154..1236 CDD:276805 14/93 (15%)
PHD_SF 1237..1271 CDD:304600 12/34 (35%)
HAT_KAT11 1300..1607 CDD:285432 56/334 (17%)
ZZ_CBP 1663..1703 CDD:239077 14/72 (19%)
ZnF_TAZ 1724..1802 CDD:214717 16/88 (18%)
Creb_binding <2164..2231 CDD:286163 18/87 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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