DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and nsd1b

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_005173940.1	Gene:	nsd1b / 564592	ZFINID:	ZDB-GENE-080519-2	Length:	1873	Species:	Danio rerio

Alignment Length:	1195	Identity:	225/1195 - (18%)
Similarity:	376/1195 - (31%)	Gaps:	431/1195 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 QQDSNDTKYVKCEQCQKT--YHASCLRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSH 320
            :..|..|..:....||::  ..|..|.|....||                  :|....|:|
Zfish   894 EDQSQSTPLINTLPCQESQVLSAETLTPPPEIIP------------------SPCDNISNR---- 936

  Fly   321 YTICDSCYQQRNKGFSCPICQKAYRAASHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDY 385
                |...:|........:|..:.|   .::..|     |.:.|:.:.|..|....|.|...
Zfish   937 ----DQLQRQNPVAVGDSVCLNSKR---QRKPTK-----KILESSIEAEPILIPKRKMKSMK--- 986

  Fly   386 DYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSEQLSLKEIELDPLEGKPTMDPSSDELHKLPTG 450
              :|.:  .:|:..|..||:         ..|..:||::           :.||.||.:.|
Zfish   987 --ICSS--GHSTNSGVEQQS---------SKSKNKLSIE-----------SSDPPSDPMLK---- 1023

  Fly   451 KKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQLALPTISSDRCLSRSMETDLTSDKKL 515
                 .|.:.......||..:...|..:...:.|..|.|:   |.||:....|  |.:..|| |:
Zfish  1024 -----STEMEIDVSPAVLQTINTESADDGSDTLRCSGSQM---TESSEFYSER--EENSQSD-KV 1077

  Fly   516 LLCSAR------DKFIQAQDICVMCGSLGIESDSVMITC-AQCGQCYHPYCAGV-KPSRGILQKG 572
            ||.|.|      ......:::|.||     |....::.| .||...:||.|.|: :|..|    .
Zfish  1078 LLDSRRLSEEKGGSTSVKENVCPMC-----EKQGDLLLCEGQCCGAFHPQCTGLNEPPTG----K 1133

  Fly   573 WRCLDCT----VCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGN-WKCSF--CTLC-- 628
            :.|.:||    .|..|.:..::.|..:...|...||..|......|||... ::|..  |..|
Zfish  1134 FLCQECTSGVHSCFACKRLGEDVRRCMVPGCGKFYHGECAASHAPTVPLNRAFRCPLHACLSCFI 1198

  Fly   629 -------------QKCGRNPT--EKSEF---------GDSNMLECPS-------CTSQ-----SS 657
                         .:|.|.|.  ..|:|         .|||:: ||:       |.:.     |.
Zfish  1199 LNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIV-CPNHFTPRKGCRNHEHVNVSW 1262

  Fly   658 CPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRCSTRSTNSLADAKF 722
            |.||    |.|..::.||.|....|..|      |.||..:.:.| |..||.
Zfish  1263 CFVC----SEGGSLLCCESCPAAFHREC------LNIDMPEGSWY-CNDCRA------------- 1303

  Fly   723 GNEDSLAITPQGSKP----FVHITASSGPSFDSKSG------AERNHPTLSGDMPESAPEALHWI 777
                       |.||    .|.:          |.|      ||.::|.   |:||:.....|.:
Zfish  1304 -----------GKKPHYKEVVWV----------KVGRYRWWPAEVSNPK---DIPENILRMKHDV 1344

  Fly   778 DGVCLSESGLG---------MIKSLSTEIKRKRKMRQALGNGKDGQLEAAAEEALEKYKDGMVWD 833
            ....:...|..         :...:..:...|.||    |.|.|...:.|.:||..::|:
Zfish  1345 GEFPVLFFGSNDYLWTYQARVFPYMEGDANSKEKM----GKGVDSTYKKALDEAALRFKE----- 1400

  Fly   834 GTENAIPEGFTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMD 898
                                :..:|..|.||:                       |:.|     |
Zfish  1401 --------------------LQAEKELRQLQE-----------------------DRRN-----D 1417

  Fly   899 KKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLL---EGGELVMADTDSSDE----IDAS----MKV 952
            ||....::.:.||     |       |||.|:   :..|:...:..::||    :|:.    |.:
Zfish  1418 KKPPPYKQIKVNK-----P-------FGKVLIISADLSEIPRCNCKATDENPCGMDSECINRMLL 1470

  Fly   953 YFTRPE----GKSPANQDTLAVNKSPAKTVKKVKA--------ELKTENKTVFIQQMPMGIQNKN 1005
            |...|:    |:...||..:.......:|.:.:..        ::|   |..||.:.
Zfish  1471 YECHPQVCPAGERCQNQCFIKRQYCQVETFRTLSRGWGLRCVHDIK---KGGFISEY-------- 1524

  Fly  1006 GTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLV 1070
                |..|.|..:.         |..:......|:....|.    |:....:|:...:.:.|..:
Zfish  1525 ----VGEVIDEEEC---------RARIKHAQENNIGNFYML----TLDKDRIIDAGPKGNEARFM 1572

  Fly  1071 DSFMVPNQLPQEQKFHNQLYLGGNTLVN-PA-QQLQFRQQAPQNANKQ---NMQTI--------- 1121
            :....||...|:...:....:|..:|.: || .:|.|      |.|.:   |.:|:
Zfish  1573 NHCCQPNCETQKWTVNGDTRVGLFSLTDIPAGTELTF------NYNLECLGNGKTVCKCGASNCS 1631

  Fly  1122 ------------MSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDE-----DLGLMAT 1169
                        ......:.:|:.:.:|:|:                |.|:||     |.|.:
Zfish  1632 GFLGVRPKNNPPSDDKGRKLKKKRKSQQEVI----------------KEREDECFSCGDGGQI-- 1678

  Fly  1170 ISAVLYANTEHPNLKELFPIWNDRCKQILKR--------WR--SLCNEKKAPFLQKAK------- 1217
                  .:.:.|...:   :::..|..:.||        |.  .||.::.|.|.:...
Zfish  1679 ------VSCKRPGCPK---VYHADCLNLTKRPAGRWECPWHQCDLCGQEAASFCEMCPSSYCVEH 1734

  Fly  1218 ----------DNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTYNGNAYDM 1272
                      |.|.:..:..     |..|:|.   |.|.:.:.|.:|:...|...:....|.
Zfish  1735 RDGMLFISKLDGRLSCSEHD-----PCGPEPL---EPGEIREYPGELRPTYPINIIKSAKNK--- 1788

  Fly  1273 GNYVGGSAQAASNNPNPHHVMPNVN 1297
             :::..:.:|....|:|..|.|.|:
Zfish  1789 -SHILNTPKAVPQAPSPLDVAPQVS 1812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985	9/41 (22%)
		PHD_SF	337..392	CDD:304600	10/54 (19%)
		PHD4_KMT2C_like	530..578	CDD:276987	14/49 (29%)
		PHD5_KMT2C_like	580..625	CDD:276988	11/47 (23%)
		PHD6_KMT2C_like	657..707	CDD:276989	15/49 (31%)
		NHP6B	1101..>1237	CDD:227935	27/191 (14%)
		HMG	1173..1231	CDD:197700	11/84 (13%)
nsd1b	XP_005173940.1	PWWP	132..>204	CDD:321985
		TOP2c	<652..1020	CDD:330395	34/186 (18%)
		PHD_SF	1098..1140	CDD:328929	14/50 (28%)
		PHD_SF	1145..1191	CDD:328929	11/45 (24%)
		PHD_SF	1193..1245	CDD:328929	12/52 (23%)
		PHD4_NSD1	1262..1301	CDD:277126	15/49 (31%)
		WHSC1_related	1307..1401	CDD:99899	22/135 (16%)
		AWS	1444..1494	CDD:197795	10/49 (20%)
		SET	1497..1618	CDD:214614	25/154 (16%)
		PHD5_NSD1	1668..1710	CDD:277129	7/52 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030