DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and baz2ba

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_021332704.1	Gene:	baz2ba / 561095	ZFINID:	ZDB-GENE-070615-37	Length:	2318	Species:	Danio rerio

Alignment Length:	362	Identity:	72/362 - (19%)
Similarity:	122/362 - (33%)	Gaps:	114/362 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 HRMGVMSQINKKRSTRGKGRQLALPTISSDRCLSRSMETDLTSDKKLL-----------LCSARD 522
            ||.|..|| .::.|.:|..|:   |:...|..:.|..|.:...:::.|           |.:...
Zfish  1949 HRPGAESQ-EERSSEKGLIRR---PSNPLDIAVMRLAELERHIERRYLRSPLGTTIQIKLDNVGT 2009

  Fly   523 KFIQAQDICVMCGSLGIESD------------SVMITCAQCGQCYHPYCAGVKPSRGILQKGWRC 575
            ..:.|.......|..|.|.:            |.:.:.:|...|.......:...:.|::
Zfish  2010 VTVPAPAPSTSAGGEGGEEEIAPGMKLWRKALSEVRSSSQLAMCLQQLQKSIAWEKSIMK----- 2069

  Fly   576 LDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSE 640
               ..|:.|.|.::|..|||||.||...|.||..|.:.|:|.|:|.|..| :.:..|::|..||:
Zfish  2070 ---VYCQICRKGDNEDLLLLCDGCDKGCHTYCHKPKITTIPEGDWYCPDC-ISKASGQSPKSKSK 2130

  Fly   641 FGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCF 705
            ..:..   .|:...:.:....|.|....|...:.|
Zfish  2131 TPNRT---APASGGKKTAEAAKKSKKQAETGEEEE------------------------------ 2162

  Fly   706 KCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMPESA 770
                :|.||||              ||:        .|::..|.:.|:.|  :.|......|:|.
Zfish  2163 ----ATSSTNS--------------TPK--------KATAASSQNKKNSA--STPNQMAPKPDSP 2199

  Fly   771 PEALHWIDGVCLSES--------GLGMIKSLSTEIKR 799
                     .|:..:        .||:.:.|..|::|
Zfish  2200 ---------ACVKRAKTARDNNRDLGLCRILLAELER 2227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987	7/59 (12%)
		PHD5_KMT2C_like	580..625	CDD:276988	20/44 (45%)
		PHD6_KMT2C_like	657..707	CDD:276989	4/49 (8%)
		NHP6B	1101..>1237	CDD:227935
		HMG	1173..1231	CDD:197700
baz2ba	XP_021332704.1	HAT_MBD	809..880	CDD:238691
		TPH	952..>1143	CDD:316391
		DDT	1167..1227	CDD:214726
		WSD	1450..>1470	CDD:317927
		WSD	<1824..1856	CDD:317927
		PHD_BAZ2B	2070..2118	CDD:277100	21/48 (44%)
		BAH	2093..>2145	CDD:322012	15/55 (27%)
		ADK	<2119..2209	CDD:331878	24/159 (15%)
		Bromo_BAZ2A_B_like	2214..2310	CDD:99935	5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900